[1]马忠超,于亚民,臧雯雯,等.糖尿病肾脏疾病患者总胆红素、血尿酸与动脉粥样硬化相关性分析[J].医学信息,2023,36(12):116-119.[doi:10.3969/j.issn.1006-1959.2023.12.022]
　MA Zhong-chao,YU Ya-min,ZANG Wen-wen,et al.Correlation Analysis of Total Bilirubin, Serum Uric Acid and Atherosclerosis in Patients with Diabetic Kidney Disease[J].Journal of Medical Information,2023,36(12):116-119.[doi:10.3969/j.issn.1006-1959.2023.12.022]
点击复制

糖尿病肾脏疾病患者总胆红素、血尿酸与动脉粥样硬化相关性分析()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年12期
页码:
116-119
栏目:
论著
出版日期:
2023-06-15

文章信息/Info

Title:
Correlation Analysis of Total Bilirubin, Serum Uric Acid and Atherosclerosis in Patients with Diabetic Kidney Disease
文章编号:
1006-1959（2023）12-0116-04
作者:
马忠超; 于亚民; 臧雯雯; 等
（聊城市人民医院肾内科，山东 聊城 252000）
Author(s):
MA Zhong-chao; YU Ya-min; ZANG Wen-wen; et al.
(Department of Nephrology,Liaocheng People’s Hospital,Liaocheng 252000,Shandong,China)
关键词:
糖尿病肾脏疾病; 动脉粥样硬化; 高尿酸血症; 低胆红素血症
Keywords:
Diabetic kidney disease; Atherosclerosis; Hyperuricemia; Hypobilirubinemia
分类号:
R692.5
DOI:
10.3969/j.issn.1006-1959.2023.12.022
文献标志码:
A
摘要:
目的 探讨糖尿病肾脏疾病（DKD）患者总胆红素、血尿酸与颈动脉粥样硬化（AS）的关系。方法 选取2019年2月-2022年5月聊城市人民医院肾内科收治的90例DKD患者为研究对象，按照慢性肾脏病（CKD）分期分为CKD1~2期、CKD3~4期、CKD5期组，各30例，另选同期健康成年人20名为对照组。记录临床及生化指标，彩超检测颈动脉内膜-中层厚度（CCA-IMT）及粥样硬化斑块（CP）情况，比较各组临床生化及超声指标，分析DKD患者临床生化指标与AS的相关性。结果 各组空腹血糖（FBG）、尿素氮（BUN）、肌酐（Cr）、总胆红素（TBIL）、血尿酸（SUA）、收缩压（SBP）、甘油三酯（TG）、IMT、CP比较，差异有统计学意义（P＜0.05）；单因素相关性分析显示，TBIL与肾小球滤过率（eGFR）呈正相关，与SBP、舒张压（SBP）、BUN、Cr、SUA、IMT呈负相关，SUA与SBP、DBP、BUN、Cr、IMT呈正相关，与TBIL、eGFR呈负相关；多因素线性回归分析显示，TBIL、SUA、总胆固醇（TC）、SBP、eGFR是DKD患者发生AS的危险因素。结论 低胆红素血症和高尿酸血症是糖尿病肾脏疾病患者动脉粥样硬化的独立危险因素，这些因素参与了动脉粥样硬化的进展。
Abstract:
Objective To investigate the relationship between total bilirubin, serum uric acid and carotid atherosclerosis in patients with diabetic kidney disease (DKD).Methods A total of 90 patients with DKD admitted to the Department of Nephrology, Liaocheng People’s Hospital from February 2019 to May 2022 were selected as the research objects. According to the stage of chronic kidney disease (CKD), they were divided into CKD1-2 group, CKD3-4 group and CKD5 group, with 30 patients in each group. The clinical and biochemical indexes were recorded, and the carotid intima-media thickness (CCA-IMT) and atherosclerotic plaque (CP) were detected by color Doppler ultrasound. The clinical biochemical and ultrasonic indexes of each group were compared, and the correlation between clinical biochemical indexes and atherosclerosis (AS) in DKD patients was analyzed.Results There were significant differences in fasting blood glucose (FBG), urea nitrogen (BUN), creatinine (Cr), total bilirubin (TBIL), serum uric acid (SUA), systolic blood pressure (SBP), triglyceride (TG), IMT and CP among the groups (P<0.05). Univariate correlation analysis showed that TBIL was positively correlated with glomerular filtration rate (eGFR), and negatively correlated with SBP, diastolic blood pressure (SBP), BUN, Cr, SUA and IMT; SUA was positively correlated with SBP, DBP, BUN, Cr and IMT, and negatively correlated with TBIL and eGFR. Multivariate linear regression analysis showed that TBIL, SUA, total cholesterol (TC), SBP and eGFR were risk factors for AS in DKD patients.Conclusion Hypobilirubinemia and hyperuricemia are independent risk factors for atherosclerosis in patients with diabetic kidney disease, and these factors are involved in the progression of atherosclerosis.

参考文献/References:

[1]Brunelli N,Altamura C,Costa CM,et al.Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness[J].Int J Environ Res Public Health,2022,19(2):758.[2]Ren H,Zhao L,Zou Y,et al.Association between atherosclerotic cardiovascular diseases risk and renal outcome in patients with type 2 diabetes mellitus[J].Ren Fail,2021,43(1):477-487.[3]于丽娜,耿巍,房伟,等.高脂饮食联合内膜损伤对动脉粥样硬化的作用及对炎症因子的影响[J].医学信息,2022,35(2):79-82. [4]Tan?覦nd?覦 A,Erkan AF,Alhan A,et al.Arterial stiffness and central arterial wave reflection are associated with serum uric acid, total bilirubin, and neutrophil-to-lymphocyte ratio in patients with coronary artery disease[J].Anatol J Cardiol,2015,15(5):396-403.[5]Wen G,Yao L,Hao Y,et al.Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system[J].J Transl Med,2022,20(1):1.[6]Lapenna D,Ciofani G,Pierdomenico SD,et al.Association of serum bilirubin with oxidant damage of human atherosclerotic plaques and the severity of atherosclerosis[J].Clin Exp Med,2018,18(1):119-124.[7]Tao X,Wu J,Wang A,et al.Lower Serum Indirect Bilirubin Levels are Inversely Related to Carotid Intima-Media Thickness Progression[J].Curr Neurovasc Res,2019,16(2):148-155.[8]秦璐,谷永胜,李琳,等.健康体检人群血清胆红素水平对颈动脉粥样硬化进展影响的队列研究[J].中国全科医学,2022,25(13):1576-1581.[9]Lee I,Lee HH,Cho Y,et al.Association Between Serum Bilirubin and the Progression of Carotid Atherosclerosis in Type 2 Diabetes[J].J Lipid Atheroscler,2020,9(1):195-204.[10]Durante W.Targeting Heme Oxygenase-1 in the Arterial Response to Injury and Disease[J].Antioxidants (Basel) ,2020,9(9):829.[11]Wu G,Zhang J,Zhao Q,et al.Molecularly Engineered Macrophage-Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment[J].Angew Chem Int Ed Engl,2020,59(10):4068-4074.[12]Borghi C,Desideri G.Urate-lowering drugs and prevention of cardiovascular disease: The emerging role of xanthine oxidase inhibition[J].Hypertension,2016,67(3):496-498.[13]Chen C,Lü JM,Yao Q.Hyperuricemia-Related Diseases and Xanthine Oxidoreductase (XOR) Inhibitors: An Overview[J].Med Sci Monit,2016,22:2501-2512.[14]Sun N,Zhang Y,Tian JL,et al.Relationship between uric acid and arterial stiffness in the elderly with metabolic syndrome components[J].Chin Med J,2013,126(16):3097-3102.[15]Lee TS,Lu TM,Chen CH,et al.Hyperuricemia induces endothelial dysfunction and accelerates atherosclerosis by disturbing the asymmetric dimethylarginine/dimethylarginine dimethylaminotransferase 2 pathway[J].Redox Biol,2021,46:102108.[16]Gherghina ME,Peride I,Tiglis M,et al.Uric Acid and Oxidative Stress-Relationship with Cardiovascular, Metabolic, and Renal Impairment[J].Int J Mol Sci,2022,23(6):3188.[17]Polito L,Bortolotti M,Battelli MG,et al.Xanthine oxidoreductase: A leading actor in cardiovascular disease drama[J].Redox Biol,2021,48:102195.[18]De Lima Balico L,Gaucher EA.CRISPR-Cas9-mediated reactivation of the uricase pseudogene in human cells prevents acute hyperuricemia[J].Mol Ther Nucleic Acids,2021,25:578-584.[19]Lin A,Sun Z,Xu X,et al.Self-Cascade Uricase/Catalase Mimics Alleviate Acute Gout[J].Nano Lett,2022,22(1):508-516.[20]Takahashi T,Beppu T,Hidaka Y,et al.Comparative study of a novel selective urate reabsorption inhibitor "dotinurad" among patient groups with different stages of renal dysfunction[J].Clin Exp Nephrol,2021,25(12):1336-1345.

相似文献/References:

[1]王立民,刘有旺,王恩波,等.以大黄素为声敏剂介导声动力疗法对小鼠 动脉粥样硬化治疗作用的研究[J].医学信息,2018,31(06):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
　WANG Li-min,LIU You-wang,WANG En-bo,et al.Study on the Effect of Emodin on the Treatment of Atherosclerosis in Mice[J].Journal of Medical Information,2018,31(12):58.[doi:10.3969/j.issn.1006-1959.2018.06.019]
[2]杨玉媛,刘有旺,李 腾,等.Th17细胞对动脉粥样硬化斑块易损性和斑块破裂的影响研究[J].医学信息,2018,31(18):53.[doi:10.3969/j.issn.1006-1959.2018.18.017]
　YANG Yu-yuan,LIU You-wang,LI Teng,et al.Effect of Th17 Cells on Atherosclerotic Plaque Vulnerability and Plaque Rupture[J].Journal of Medical Information,2018,31(12):53.[doi:10.3969/j.issn.1006-1959.2018.18.017]
[3]陈玉媛,易爱姣,谭齐鸣,等.中青年冠状动脉粥样硬化患者颈动脉硬化的超声特征[J].医学信息,2019,32(02):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
　CHEN Yu-yuan,YI Ai-jiao,TAN Qi-ming,et al.Ultrasound Characteristics of Carotid Atherosclerosis in Young and Middle-aged Patients with Coronary Atherosclerosis[J].Journal of Medical Information,2019,32(12):175.[doi:10.3969/j.issn.1006-1959.2019.02.054]
[4]郝冬冬,高 宇.C肽与动脉粥样硬化的相关性研究[J].医学信息,2019,32(09):28.[doi:10.3969/j.issn.1006-1959.2019.09.010]
　HAO Dong-dong,GAO Yu.Correlation between C-peptide and Atherosclerosis[J].Journal of Medical Information,2019,32(12):28.[doi:10.3969/j.issn.1006-1959.2019.09.010]
[5]严文文,陈 然,金 平,等.老年患者颅内动脉粥样硬化性狭窄的分布和危险因素研究[J].医学信息,2019,32(09):78.[doi:10.3969/j.issn.1006-1959.2019.09.025]
　YAN Wen-wen,CHEN Ran,JIN Ping,et al.Distribution and Risk Factors of Intracranial Atherosclerotic Stenosis in Elderly Patients[J].Journal of Medical Information,2019,32(12):78.[doi:10.3969/j.issn.1006-1959.2019.09.025]
[6]李慧丹,赵文鸽,王学惠.Nox4在同型半胱氨酸介导的动脉粥样硬化中作用的研究[J].医学信息,2019,32(15):45.[doi:10.3969/j.issn.1006-1959.2019.15.015]
　LI Hui-dan,ZHAO Wen-ge,WANG Xue-hui.Research on the Role of Nox4 in Homocysteine-mediated Atherosclerosis[J].Journal of Medical Information,2019,32(12):45.[doi:10.3969/j.issn.1006-1959.2019.15.015]
[7]薛 一,孔莫维,高 宇.脂蛋白相关磷脂酶A2与冠心病的研究[J].医学信息,2019,32(12):53.[doi:10.3969/j.issn.1006-1959.2019.12.017]
　XUE Yi,KONG Mo-wei,GAO Yu.Research on Lipoprotein-associated Phospholipase A2 and Coronary Heart Disease[J].Journal of Medical Information,2019,32(12):53.[doi:10.3969/j.issn.1006-1959.2019.12.017]
[8]黄梦倩,张瑞恒,刘楚浩,等.影像组学在神经系统疾病中的应用研究[J].医学信息,2019,32(16):47.[doi:10.3969/j.issn.1006-1959.2019.16.015]
　HUANG Meng-qian,ZHANG Rui-heng,LIU Chu-hao,et al.Application of Radiomics in Nervous System Diseases[J].Journal of Medical Information,2019,32(12):47.[doi:10.3969/j.issn.1006-1959.2019.16.015]
[9]高诗奇,邓代华,杨 静.成纤维细胞生长因子21抗动脉粥样硬化作用的研究[J].医学信息,2020,33(19):28.[doi:10.3969/j.issn.1006-1959.2020.19.009]
　GAO Shi-qi,DENG Dai-hua,YANG Jing.Study on Anti-atherosclerosis Effect of Fibroblast Growth Factor 21[J].Journal of Medical Information,2020,33(12):28.[doi:10.3969/j.issn.1006-1959.2020.19.009]
[10]张 蕊,耿 佳,王雪梅.长链非编码RNA在内皮细胞损伤模型中的表达调控研究[J].医学信息,2020,33(22):71.[doi:10.3969/j.issn.1006-1959.2020.22.022]
　ZHANG Rui,GENG Jia,WANG Xue-mei.Study on the Expression Regulation of Long Non-coding RNA in Endothelial Cell Injury Model[J].Journal of Medical Information,2020,33(12):71.[doi:10.3969/j.issn.1006-1959.2020.22.022]

更新日期/Last Update: 1900-01-01