[1]柳旭丽,徐 红,刘金香,等.TIPE2、TNF-α、MMP-22在冠心病的表达和意义[J].医学信息,2023,36(24):42-45.[doi:10.3969/j.issn.1006-1959.2023.24.007]
　LIU Xu-li,XU Hong,LIU Jin-xiang,et al.Expression and Significance of TIPE2, TNF-α, MMP-22 in Coronary Heart Disease[J].Journal of Medical Information,2023,36(24):42-45.[doi:10.3969/j.issn.1006-1959.2023.24.007]
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TIPE2、TNF-α、MMP-22在冠心病的表达和意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
36卷
期数:
2023年24期
页码:
42-45
栏目:
论著
出版日期:
2023-12-15

文章信息/Info

Title:
Expression and Significance of TIPE2, TNF-α, MMP-22 in Coronary Heart Disease
文章编号:
1006-1959（2023）24-0042-04
作者:
柳旭丽; 徐 红; 刘金香; 等
（1.昌邑市人民医院特检科，山东 昌邑 261300；2.昌邑市人民医院检验科，山东 昌邑 261300；3.潍坊市人民医院创伤骨科，山东 潍坊 261041）
Author(s):
LIU Xu-li; XU Hong; LIU Jin-xiang; et al.
(1.Department of Special Inspection,Changyi People’s Hospital,Changyi 261300,Shandong,China;2.Department of Clinical Laboratory,Changyi People’s Hospital,Changyi 261300,Shandong,China;3.Department of Orthopedics and Trauma,Weifang People’s Hospital,Weifang 261041,Shandong,China)
关键词:
TIPE2; TNF-α; MMP-22; 冠心病
Keywords:
TIPE2; TNF-α; MMP-22; Coronary heart disease
分类号:
R541.4
DOI:
10.3969/j.issn.1006-1959.2023.24.007
文献标志码:
A
摘要:
目的 探究冠心病患者血清中TIPE2、TNF-α、MMP-22的表达水平及与病情严重程度的相关性。方法 将2018年1月-2021年12月昌邑市人民医院收治的冠心病患者60例纳入试验组，另选取同期健康查体者60人纳入对照组。比较两组血清TIPE2、TNF-α、MMP-22表达水平，并分析其与常用临床指标的关系，另采用Pearson相关性分析TIPE2与TNF-α、MMP-22的关系。结果 试验组血清TIPE2表达水平低于对照组，而TNF-α、MMP-22表达水平高于对照组（P＜0.05）；TIPE2、TNF-α、MMP-22的表达与冠状动脉狭窄程度及心电图QRS波时限有关；Pearson相关性分析显示，TIPE2表达与TNF-α（r＝-0.287，P＝0.013）、MMP-22（r＝-0.283，P＝0.014）表达呈负相关。结论 冠心病患者中TIPE2表达降低，而TNF-α、MMP-22表达升高，并且TIPE2、TNF-α、MMP-22的表达异常参与了冠心病的形成和发生发展。
Abstract:
Objective To explore the expression level and clinical diagnostic value of serum TIPE2, TNF-α and MMP-22 in patients with coronary heart disease.Methods A total of 60 patients with coronary heart disease admitted to Changyi People’s Hospital from January 2018 to December 2021 were included in the experimental group, and 60 healthy people in the same period were selected as the control group. The expression levels of serum TIPE2, TNF-α and MMP-22 were compared between the two groups, and their relationship with common clinical indicators was analyzed. Pearson correlation was used to analyze the relationship between TIPE2 and TNF-α and MMP-22.Results The expression level of serum TIPE2 in the experimental group was lower than that in the control group, while the expression levels of TNF-α and MMP-22 were higher than those in the control group (P<0.05). The expression of TIPE2, TNF-α and MMP-22 was related to the degree of coronary artery stenosis and the duration of QRS wave. Pearson correlation analysis showed that TIPE2 expression was negatively correlated with TNF-α(r=-0.287, P=0.013) and MMP-22 (r=-0.283, P=0.014).Conclusion The expression of TIPE2 in patients with coronary heart disease is decreased, while the expression of TNF-α and MMP-22 is increased, and the abnormal expression of TIPE2, TNF-α and MMP-22 is involved in the formation and development of coronary heart disease.

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更新日期/Last Update: 1900-01-01