[1]陆岸锋,黄海燕,黄 萍,等.妊娠期糖尿病对早期新生儿呼吸系统疾病的影响[J].医学信息,2024,37(18):70-74.[doi:10.3969/j.issn.1006-1959.2024.18.012]
　LU An-feng,Huang Hai-yan,HUANG Ping,et al.Effect of Gestational Diabetes Mellitus on Early Neonatal Respiratory Diseases[J].Journal of Medical Information,2024,37(18):70-74.[doi:10.3969/j.issn.1006-1959.2024.18.012]
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妊娠期糖尿病对早期新生儿呼吸系统疾病的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年18期
页码:
70-74
栏目:
论著
出版日期:
2024-09-15

文章信息/Info

Title:
Effect of Gestational Diabetes Mellitus on Early Neonatal Respiratory Diseases
文章编号:
1006-1959（2024）18-0070-05
作者:
陆岸锋1; 黄海燕1; 黄 萍2; 黄培禄1; 毕 雷1; 黄国盛1
钦州市妇幼保健院新生儿科1，产科2，广西 钦州 535099
Author(s):
LU An-feng1; Huang Hai-yan1; HUANG Ping2; HUANG Pei-lu1; BI Lei1; HUANG Guo-sheng1
Department of Neonatology1,Department of Obstetrics2,Qinzhou Meternal and Child Health Care Hospital,Qinzhou 535099,Guangxi,China
关键词:
妊娠期糖尿病; 呼吸系统疾病; 新生儿; 血糖; 湿肺
Keywords:
Gestational diabetes mellitus; Respiratory diseases; Neonate; Blood glucose; Wet lung
分类号:
R714.256
DOI:
10.3969/j.issn.1006-1959.2024.18.012
摘要:
目的 探讨母亲妊娠期糖尿病（GDM）对早期新生儿呼吸系统疾病的影响。方法 以2018年1月-12月钦州市妇幼保健院产科分娩的单胎、活产新生儿5702例为研究对象，根据母亲是否患GDM将新生儿分为GDM组（n=830）和非GDM组（n=4872）；再根据其母孕期血糖是否在控制目标值内，将GDM组分为血糖控制达标组（n=755）和血糖控制不达标组（n=75）。比较各组新生儿呼吸窘迫综合征（RDS）、新生儿湿肺、感染性肺炎、气胸、胎粪吸入综合征的发生率和机械通气需求情况。结果 GDM组早产（10.60% vs.7.02%）、巨大儿（5.42% vs.2.36%）、剖宫产（42.41% vs.34.56%）发生率高于非GDM组，差异有统计学意义（P＜0.05）；GDM组湿肺发生率高于非GDM组（1.20% vs.0.39%，P＜0.05）。母亲孕期血糖控制不达标组呼吸系统疾病（17.33% vs.2.91%）、新RDS（5.33% vs.1.32%）、湿肺（8.00% vs.0.53%）发生率高于血糖控制达标组，需要呼吸支持的比例高于血糖控制达标组（8.0% vs.1.2%），差异有统计学意义（P＜0.05）；GDM母亲血糖控制不达标是呼吸系统疾病（OR=6.986，95%CI：3.357~14.540， P=0.000）、新生儿湿肺（OR=3.593，95%CI：1.990~6.488，P=0.000）的危险因素。结论 孕期血糖控制不良的GDM母亲分娩的新生儿呼吸系统疾病、RDS、湿肺的发生率和需呼吸支持比例增高，GDM母亲血糖控制不达标是呼吸系统系统疾病、新生儿湿肺的危险因素，应重视GDM母亲围产保健，使其孕期的血糖得到良好控制以改善新生儿的临床预后。
Abstract:
Objective To investigate the effect of maternal gestational diabetes mellitus (GDM) on early neonatal respiratory diseases.Methods A total of 5702 singleton and live birth newborns delivered in the Department of Obstetrics, Qinzhou Maternal and Child Health Care Hospital from January to December 2018 were selected as the research objects. According to whether the mother had GDM, the newborns were divided into GDM group (n=830) and non-GDM group (n=4872). According to whether the maternal blood glucose during pregnancy was within the control target value, the GDM group was divided into the blood glucose control target group (n=755) and the blood glucose control non-target group (n=75). The incidence of neonatal respiratory distress syndrome (RDS), neonatal wet lung, infectious pneumonia, pneumothorax, meconium aspiration syndrome and mechanical ventilation requirements were compared among the groups.Results The incidences of premature delivery (10.60% vs.7.02%), macrosomia (5.42% vs.2.36%) and cesarean section (42.41% vs.34.56%) in GDM group were higher than that in non-GDM group, and the difference were statistically significant (P<0.05). The incidence of wet lung in GDM group was higher than that in non-GDM group (1.20% vs.0.39%, P<0.05. The incidences of respiratory diseases (17.33% vs.2.91%), RDS (5.33% vs.1.32%), wet lung (8.00% vs.0.53%) and the need for respiratory support (8.0% vs.1.2%) in the blood glucose control target group were higher than those in the blood glucose control non-target group, and the differences were statistically significant (P<0.05). The substandard blood glucose control of GDM mothers was a risk factor for respiratory diseases (OR=6.986, 95%CI:3.357-14.540, P=0.000) and neonatal wet lung (OR=3.593, 95%CI:1.990-6.488, P=0.000). Conclusion The incidence of neonatal respiratory diseases, RDS, wet lung and the proportion of respiratory support are increased in GDM mothers with poor blood glucose control during pregnancy. The substandard blood glucose control of GDM mothers is a risk factor for respiratory diseases and neonatal wet lung. We should pay attention to the perinatal health care of GDM mothers, so that their blood glucose during pregnancy can be well controlled to improve the clinical prognosis of newborns.

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更新日期/Last Update: 1900-01-01