[1]丁晓燕.肥胖伴有哮喘儿童血清瘦素、脂联素和视黄酸受体反应蛋白2与肺功能的相关性研究[J].医学信息,2024,37(18):75-78.[doi:10.3969/j.issn.1006-1959.2024.18.013]
　DING Xiao-yan.Study on the Correlation Between Serum Leptin, Adiponectin, Retinoic Acid Receptor-reactive Protein 2 and Lung Function in Obese Children with Asthma[J].Journal of Medical Information,2024,37(18):75-78.[doi:10.3969/j.issn.1006-1959.2024.18.013]
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肥胖伴有哮喘儿童血清瘦素、脂联素和视黄酸受体反应蛋白2与肺功能的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年18期
页码:
75-78
栏目:
论著
出版日期:
2024-09-15

文章信息/Info

Title:
Study on the Correlation Between Serum Leptin, Adiponectin, Retinoic Acid Receptor-reactive Protein 2 and Lung Function in Obese Children with Asthma
文章编号:
1006-1959（2024）18-0075-04
作者:
丁晓燕
丹阳市妇幼保健院儿科，江苏 丹阳 212300
Author(s):
DING Xiao-yan
Department of Pediatrics,Danyang Maternal and Child Health Care Hospital,Danyang 212300,Jiangsu,China
关键词:
血清瘦素; 脂联素; 视黄酸受体反应蛋白2; 肺功能; 肥胖哮喘
Keywords:
Serum leptin; Adiponectin; Retinoic acid receptor-reactive protein 2; Lung function; Obese asthma
分类号:
R723.14；R256.12
DOI:
10.3969/j.issn.1006-1959.2024.18.013
摘要:
目的 探讨血清瘦素、脂联素及视黄酸受体反应蛋白2水平同肥胖伴有哮喘患儿肺功能的相关性。方法 选择2021年6月-2022年6月我院就诊的70例哮喘患儿为研究对象，根据患儿体重指数将其分为正常组（n=35）和肥胖组（n=35）。对比两组患儿血清瘦素、脂联素及视黄酸受体反应蛋白2表达水平，采用肺功能仪检测两组患儿的用力肺活量（FVC）所占预估值百分率（FVC%）和第1秒用力呼气容积（FEV1）所占预估值百分率（FEV1%）；分析血清瘦素、脂联素及视黄酸受体反应蛋白2与肥胖哮喘患儿肺功能的相关性。结果 肥胖组患儿FVC%、FEV1%、脂联素表达水平低于正常组，血清瘦素和视黄酸受体反应蛋白2水平高于正常组，差异有统计学意义（P＜0.05）。患儿脂联素正表达水平与肺功能呈正相关，而瘦素和视黄酸受体反应蛋白2表达水平与肺功能呈负相关（P＜0.05）。结论 肥胖哮喘患儿血清瘦素、脂联素及视黄酸受体反应蛋白2水平均与肥胖哮喘患儿的肺功能具有较高的相关性，可作为临床预测肥胖哮喘患儿肺功能情况的有效指标。
Abstract:
Objective To investigate the correlation between serum leptin, adiponectin, retinoic acid receptor-reactive protein 2 levels and lung function in obese children with asthma.Methods A total of 70 children with asthma who were treated in our hospital from June 2021 to June 2022 were selected as the research objects. According to the body mass index of the children, they were divided into normal group (n=35) and obese group (n=35). The expression levels of serum leptin, adiponectin and retinoic acid receptor-reactive protein 2 were compared between the two groups. The percentage of forced vital capacity (FVC) in the predicted value (FVC%) and the percentage of forced expiratory volume in the first second (FEV1) in the predicted value (FEV1%) were detected by pulmonary function instrument. The correlation between serum leptin, adiponectin, retinoic acid receptor-reactive protein 2 and lung function in obese children with asthma was analyzed.Results The expression levels of FVC%, FEV1% and adiponectin in the obese group were lower than those in the normal group, and the levels of serum leptin and retinoic acid receptor-reactive protein 2 were higher than those in the normal group, the differences were statistically significant (P<0.05). The positive expression level of adiponectin was positively correlated with lung function, while the expression levels of leptin and retinoic acid receptor-reactive protein 2 were negatively correlated with lung function (P<0.05).Conclusion The levels of serum leptin, adiponectin and retinoic acid receptor-reactive protein 2 in obese children with asthma are highly correlated with the lung function of obese children with asthma, which can be used as an effective index to predict the lung function of obese children with asthma.

参考文献/References:

[1]Wang S,Sun Q,Zhai L,et al.The Prevalence of Depression and Anxiety Symptoms among Overweight/Obese and Non-Overweight/Non-Obese Children/Adolescents in China: A Systematic Review and Meta-Analysis[J].Int J Environ Res Public Health,2019,16(3):340.[2]魏娜,柴娜娜,杨羚.影响儿童支气管哮喘发病的危险因素分析[J].现代诊断与治疗,2020,31(2):275-276.[3]班紫妍,刘长富,刘梦娜,等.肺部感染对支气管哮喘患儿肺功能和Th17、TregT细胞亚群的影响及作用机制[J].中国感染与化疗杂志,2022,22(2):140-145.[4]Federico MJ,McFarlane AE 2nd,Szefler SJ,et al.The impact of social determinants of health on children with asthma[J].J Allergy Clin Immunol Pract,2020,8(6):1808-1814.[5]吕晓江,皮光环,刘崇海,等.单纯性肥胖伴哮喘患儿自身BMI变化对哮喘发作的影响[J].重庆医学,2017,46(26):3698-3700.[6]Ali Z,Ma H,Rashid MT,et al.Reduction of body weight,body fat mass,and serum leptin levels by addition of new beverage in normal diet of obese subjects[J].Journal of Food Biochemistry,2018,42(3):12554.[7]Yupanqui-Lozno H,Bastarrachea RA,Yupanqui-Velazco ME,et al.Congenital Leptin Deficiency and Leptin Gene Missense Mutation Found in Two Colombian Sisters with Severe Obesity[J].Genes (Basel),2019,10(5):342.[8]张蓉,程妍,单虎,等.食管腺癌患者血清中脂联素与炎症细胞因子水平的相关性探讨[J].现代肿瘤医学,2020,28(24):4266-4271.[9]Yu QX,Zhang H,Xu WH,et al.Effect of Irbesartan on Chemerin in the Renal Tissues of Diabetic Rats[J].Kidney Blood Press Res,2015,40(5):467-477.[10]马春利,薛满,刘伟华.肥胖对支气管哮喘患儿炎症平衡状态及肺损害的影响[J].临床和实验医学杂志,2018,17(17):1900-1903.[11]鲍一笑,陈爱欢,符州,等.儿童支气管哮喘诊断与防治指南(2016年版)[J].中华儿科杂志,2016,54(3):167-181.[12]Almabhouh FA,Md Mokhtar AH,Malik IA,et al.Leptin and reproductive dysfunction in obese men[J].Andrologia,2020,52(1):13433.[13]陆振瑜,庄承.健脾益气中药联合吸入性糖皮质激素治疗临床缓解期哮喘患儿的疗效观察[J].广西医学,2020,42(18):2361-2363,2368.[14]Michalovich D,Rodriguez-Perez N,Smolinska S,et al.Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients[J].Nat Commun,2019,10(1):5711.[15]Movahed Z,Kohan L,Fallahi S,et al.Influence of chemerin rs17173608 polymorphism on polycystic ovary syndrome susceptibility[J].Taiwan J Obstet Gynecol,2015,54(3):280-283.[16]刘玉静,纪品川,刘亚茹.不同中医体质肥胖2型糖尿病患者血清脂肪因子内脂素水平和内脏脂肪厚度分析[J].现代中西医结合杂志,2019,28(30):3338-3341.[17]卫静,吴巍,杨璐,等.2型糖尿病合并急性脑梗死患者血糖波动对体内氧化应激及炎症因子水平的影响及意义[J].现代生物医学进展,2018,18(6):1081-1084,1166.[18]杨文俊,肖迎港,张扬,等.维甲酸受体反应蛋白2活化NLRP3炎症小体在慢性阻塞性肺疾病炎性损伤中的作用机制研究[J].中国病理生理杂志,2021,37(10):1808-1814.[19]Yang S,Wang Q,Huang W,et al.Are serum chemerin levels different between obese and non-obese polycystic ovary syndrome women?[J].Gynecol Endocrinol,2016,32(1):38-41.[20]刘晓菲,梁瀛,张丛溪,等.92例哮喘患者血清瘦素与诱导痰嗜酸性粒细胞的关系[J].山东大学学报(医学版),2020,58(9):27-33.[21]杨丽敏,张妙,沈雅玉.血糖控制正常的非肥胖GDM患者妊娠中晚期体重增长对血清瘦素及妊娠结局的影响[J].中国计划生育学杂志,2020,28(2):243-246.[22]易爽,庞侯旭,袁程远,等.肥胖型支气管哮喘患儿血Clara细胞分泌蛋白及补体C3和C4水平与病情严重程度的相关性分析[J].实用医院临床杂志,2021,18(3):146-149.[23]Wasim M,Awan FR,Najam SS,et al.Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity[J].Biochem Genet,2016,54(5):565-572.[24]吕晓江,刘增荣,康迁,等.肥胖伴哮喘患儿自身体质指数变化与脂肪因子、肺功能的相关性研究[J].四川医学,2019,40(11):1090-1092.

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