[1]章勇军.乙肝两对半和DNA联合检验在乙肝诊断中的价值[J].医学信息,2024,37(21):169-172.[doi:10.3969/j.issn.1006-1959.2024.21.040]
　ZHANG Yongjun.Value of Combined Detection of HBV Antigen, Antibody and DNA in the Diagnosis of Hepatitis B[J].Journal of Medical Information,2024,37(21):169-172.[doi:10.3969/j.issn.1006-1959.2024.21.040]
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乙肝两对半和DNA联合检验在乙肝诊断中的价值()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年21期
页码:
169-172
栏目:
诊疗技术
出版日期:
2024-11-01

文章信息/Info

Title:
Value of Combined Detection of HBV Antigen, Antibody and DNA in the Diagnosis of Hepatitis B
文章编号:
1006-1959（2024）21-0169-04
作者:
章勇军
余干县中医院检验输血科，江西 余干 335100
Author(s):
ZHANG Yongjun
Department of Laboratory Blood Transfusion,Yugan County Hospital of Traditional Chinese Medicine,Yugan 335100,Jiangxi,China
关键词:
乙型肝炎病毒; 乙肝两对半; HBV-DNA
Keywords:
Hepatitis B virus; HBV antigen;  antibody; HBV-DNA
分类号:
R446.1
DOI:
10.3969/j.issn.1006-1959.2024.21.040
文献标志码:
A
摘要:
目的 研究乙肝两对半与病毒DNA（HBV-DNA）联合检验在乙肝诊断中的应用价值。方法 选取2020年1月-2023年1月余干县中医院确诊的60例乙肝患者设为乙肝组，另取同期50名体检健康者设为健康组，两组均给予乙肝两对半[乙肝表面抗原（HBsAg）、乙肝表面抗体（HBsAb）、乙肝e抗原（HBeAg）、乙肝e抗体（HBeAb）、乙肝核心抗体（HBcAb）]与HBV-DNA含量检测，比较乙肝组与健康组乙肝两对半与HBV-DNA测定结果，统计不同HBV-M模式的HBV-DNA测定结果，以综合诊断结果为金标准，分析并比较乙肝两对半、HBV-DNA单独检验及联合检验对乙肝的诊断效能。结果 乙肝组乙肝两对半指标（HBsAg、HBsAb、HBeAg、HBeAb、HBcAb）与HBV-DNA测定结果均高于健康组（P＜0.05）；不同HBV-M模式下HBV-DNA测定结果比较，差异有统计学意义（P＜0.05），其含量由高至低依次为HBsAg+HBeAg+HBcAb＞HBsAg+HBeAb+HBcAb＞HBsAg+HBcAb＞HBsAg+HBsAb+HBeAb＞HBsAg+HBeAb＞HBsAg；乙肝两对半与HBV-DNA联合检验对乙肝的诊断准确性、敏感度、特异度高于其单一检验（P＜0.05）。结论 乙肝两对半与HBV-DNA检测在乙肝诊断中均具有确切参考价值，二者联合检测可发挥更高诊断效能。
Abstract:
Objective To study the application value of combined detection of HBV antigen, antibody and viral DNA (HBV-DNA) in the diagnosis of hepatitis B.Methods A total of 60 patients with hepatitis B diagnosed in Yugan County Hospital of Traditional Chinese Medicine from January 2020 to January 2023 were selected as the hepatitis B group, and 50 healthy people in the same period were selected as the healthy group. Both groups were detected HBV antigen, antibody [hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (HBsAb), hepatitis B e antigen (HBeAg), hepatitis B e antibody (HBeAb), hepatitis B core antibody (HBcAb)] and HBV-DNA content. The results of HBV antigen, antibody and HBV-DNA in the hepatitis B group and the healthy group were compared. The results of HBV-DNA determination in different HBV-M models were statistically analyzed. Taking the comprehensive diagnosis results as the gold standard, the diagnostic efficacy of HBV antigen, antibody, HBV-DNA single test and combined test for hepatitis B was analyzed and compared.Results The results of hepatitis B two half-and-half indicators ( HBsAg, HBsAb, HBeAg, HBeAb, HBcAb) and HBV-DNA determination in the hepatitis B group were higher than those in the healthy group (P<0.05). There were significant differences in the results of HBV-DNA determination under different HBV-M modes (P<0.05), while the content of HBV-DNA from high to low was HBsAg+HBeAg+HBcAb>HBsAg+HBeAb+HBcAb>HBsAg+HBcAb>HBsAg+HBsAb+HBeAb>HBsAg+HBeAb>HBsAg. The diagnostic accuracy, sensitivity and specificity of the combined test of hepatitis B and HBV-DNA were higher than those of the single test (P<0.05).Conclusion The HBV antigen, antibody and HBV-DNA detection have definite reference value in the diagnosis of hepatitis B, and the combined detection of the two can play a higher diagnostic efficiency.

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更新日期/Last Update: 1900-01-01