[1]余 兰.不同剂量奥美拉唑治疗十二指肠球部溃疡的临床疗效及对其胃内pH值的影响[J].医学信息,2024,37(23):46-49.[doi:10.3969/j.issn.1006-1959.2024.23.010]
　YU Lan.Clinical Efficacy of Different Doses of Omeprazole in the Treatment of Duodenal Ulcer and its Effect on Gastric pH Value[J].Journal of Medical Information,2024,37(23):46-49.[doi:10.3969/j.issn.1006-1959.2024.23.010]
点击复制

不同剂量奥美拉唑治疗十二指肠球部溃疡的临床疗效及对其胃内pH值的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年23期
页码:
46-49
栏目:
论著
出版日期:
2024-12-01

文章信息/Info

Title:
Clinical Efficacy of Different Doses of Omeprazole in the Treatment of Duodenal Ulcer and its Effect on Gastric pH Value
文章编号:
1006-1959（2024）23-0046-04
作者:
余 兰
乐安县人民医院消化内二科，江西 乐安 344300
Author(s):
YU Lan
The Second Department of Gastroenterology,Le′an County People′s Hospital,Le′an 344300,Jiangxi,China
关键词:
奥美拉唑; 十二指肠球部溃疡; 胃内pH值
Keywords:
Omeprazole; Duodenal bulbar ulcer; Intragastric pH
分类号:
R573.1
DOI:
10.3969/j.issn.1006-1959.2024.23.010
文献标志码:
A
摘要:
目的 探讨不同剂量奥美拉唑治疗十二指肠球部溃疡的临床疗效及对其胃内pH值的影响。方法 选取乐安县人民医院2020年7月-2023年6月收治的72例十二指肠球部溃疡患者作为研究对象，按随机数字表法分为对照组和研究组，每组36例。对照组给予常规剂量奥美拉唑治疗，研究组给予大剂量奥美拉唑治疗，比较两组患者临床疗效、免疫功能[免疫球蛋白M（IgM）、免疫球蛋白A（IgA）、免疫球蛋白G（IgG）]、胃内pH变化情况（24 h内胃内平均pH、pH值到达4.0和6.0所需时间及达到后的持续时间）、炎性因子水平[肿瘤坏死因子-α（TNF-α）、白介素-8（IL-8）、白介素-17（IL-17）]。结果 研究组治疗总有效率高于对照组（P＜0.05）。两组治疗后患者IgM、IgA、IgG水平均升高，且研究组IgM、IgA、IgG水平高于对照组（P＜0.05）。两组患者的24 h内胃内平均pH值、pH值到达4.0及6.0持续时间比较，差异无统计学意义（P＞0.05）；而研究组患者pH值到达4.0、pH值到达6.0所需时间高于对照组（P＜0.05）。两组治疗后TNF-α、IL-8、IL-17水平均较治疗前降低，且研究组低于对照组（P＜0.05）。结论 大剂量治疗十二指肠球部溃疡患者的效果确切，能够更快改善患者胃内pH值，提高患者机体免疫功能，降低炎性因子水平，值得临床应用。
Abstract:
Objective To investigate the clinical efficacy of different doses of omeprazole in the treatment of duodenal ulcer and its effect on gastric pH.Methods A total of 72 patients with duodenal ulcer admitted to Le′an County People′s Hospital from July 2020 to June 2023 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 36 patients in each group. The control group was treated with conventional dose of omeprazole, and the study group was treated with high-dose omeprazole. The clinical efficacy, immune function [immunoglobulin M (IgM), immunoglobulin A (IgA), immunoglobulin G (IgG)], gastric pH changes (average gastric pH within 24 hours, time required for pH to reach 4.0 and 6.0, and duration after reaching), inflammatory factor levels [tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), interleukin-17 (IL-17)] were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). After treatment, the levels of IgM, IgA and IgG in the two groups increased, and the levels of IgM, IgA and IgG in the study group were higher than those in the control group (P<0.05). There was no significant difference in the average pH value in the stomach within 24 hours and the duration of pH value reaching 4.0 and 6.0 between the two groups (P＞0.05). The time required for the pH value to reach 4.0 and the pH value to reach 6.0 in the study group was higher than that in the control group (P<0.05). After treatment, the levels of TNF-α, IL-8 and IL-17 in the two groups were lower than those before treatment, and those in the study group were lower than those in the control group (P<0.05).Conclusion High-dose treatment of patients with duodenal bulb ulcer has a definite effect, which can improve the gastric pH value and immune function, reduce the level of inflammatory factors. It is worthy of clinical application.

参考文献/References:

[1]赵寅生,王教学,吴黎黎,等.基于CYP2C19基因多态性比较2种疗法在HP阳性十二指肠球部溃疡中的应用[J].安徽医学,2022,43(2):164-167.[2]程飞,甘厦,郑丽,等.含奥曲肽方案对出血性十二指肠球部溃疡患者幽门螺杆菌根除的疗效[J].实用医学杂志,2018,34(18):3097-3100.[3]黄兴广,李文波.内镜下高频电软凝术治疗介入栓塞术失败的十二指肠球部溃疡大出血1例[J].现代消化及介入诊疗,2023,28(3):399-401.[4]王静,焦丽莉,冯婷,等.14C尿素呼气试验阴性十二指肠球部溃疡临床治疗效果研究[J].临床军医杂志,2023,51(1):57-59.[5]陈涛,陈一鹏.酪酸梭菌二联活菌散联合奥美拉唑四联治疗老年胃溃疡的效果及对胃黏膜形态、肠道菌群的影响[J].中国老年学杂志,2022,42(13):3181-3184.[6]郑伟,彭克荣,李甫棒,等.幽门螺杆菌感染对十二指肠溃疡患儿十二指肠球部黏膜菌群的影响[J].中华儿科杂志,2023,61(1):49-55.[7]杨扬,张浩鑫,何朝晖.OTSC吻合夹治疗十二指肠球部溃疡并大出血后再出血的2例临床诊治体会[J].现代消化及介入诊疗,2021,26(12):1487-1489.[8]黄晓春,乔晓.桂芍香芷方治疗十二指肠球部溃疡患者临床疗效及对生活质量的影响[J].辽宁中医杂志,2023,50(2):145-148.[9]何智超,林楠,尹丕发.康复新液在幽门螺杆菌相关十二指肠球部溃疡治疗中的应用[J].宁夏医科大学学报,2019,41(1):72-74.[10]曲萌,赵微,刘小静.四逆汤加减联合复方嗜酸乳杆菌对幽门螺杆菌阳性十二指肠球部溃疡患者的作用[J].中国微生态学杂志,2021,33(9):1065-1069,1077.[11]邬礼霞,梁英,林锋,等.温中健脾、活血生肌法治疗十二指肠球部溃疡脾胃虚寒证30例[J].河南中医,2020,40(8):1243-1246.[12]李涛,王泳,鲁迪,等.国产雷贝拉唑治疗青年官兵十二指肠球部溃疡疗效观察[J].人民军医,2018,61(1):14-17.[13]庄志浩,欧阳秋伟,陶世明,等.Nissen法联合负压封闭引流治疗十二指肠球后溃疡术后残端瘘的临床研究[J].中国中西医结合急救杂志,2020,27(5):592-594.[14]张华,陆帅,王志勇.雷贝拉唑和艾司奥美拉唑治疗十二指肠溃疡的效果比较及对CRP和IL-8及IL-16的影响[J].广东医学,2020,41(14):1504-1507.[15]张馨梅,张振玉,孙士其,等.奥美拉唑碳酸氢钠胶囊治疗十二指肠溃疡119例[J].医药导报,2019,38(4):473-477.[16]丁志海,王卫,熊瑞,等.腹腔镜手术联合奥美拉唑三联治疗胃十二指肠溃疡穿孔的疗效观察[J].中国中西医结合外科杂志,2020,26(1):94-97.[17]李国栋,许亚,朱颖,等.艾司奥美拉唑与奥美拉唑治疗十二指肠溃疡的系统评价[J].中国医院用药评价与分析,2020,20(11):1359-1364.[18]董少晨,周平.艾普拉唑与艾司奥美拉唑治疗幽门螺杆菌阳性十二指肠溃疡的成本-效果分析[J].北华大学学报(自然科学版),2019,20(6):778-782.[19]王晓红.艾司奥美拉唑镁肠溶片三联方案治疗幽门螺杆菌阳性十二指肠溃疡的效果[J].实用临床医药杂志,2019,23(1):67-70.

相似文献/References:

[1]夏 铭,张正坤,曾海龙,等.四种疗法治疗幽门螺杆菌阳性消化性溃疡疗效分析[J].医学信息,2018,31(11):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
　XIA Ming,ZHANG Zheng-kun,ZENG Hai-long,et al.Therapeutic Effect of Four Kinds of Therapy on Helicobacter Pylori Positive Peptic Ulcer[J].Journal of Medical Information,2018,31(23):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
[2]吕彤观.三联疗法治疗牙周病的临床效果观察[J].医学信息,2018,31(18):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
　LV Tong-guan.Clinical Observation of Triple Therapy for Periodontosis[J].Journal of Medical Information,2018,31(23):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
[3]高华初.泮托拉唑治疗消化性溃疡合并上消化道出血的临床价值评价[J].医学信息,2018,31(22):153.[doi:10.3969/j.issn.1006-1959.2018.22.045]
　GAO Hua-chu.Clinical Value of Pantoprazole in the Treatment of Peptic Ulcer Complicated with Upper Gastrointestinal Bleeding[J].Journal of Medical Information,2018,31(23):153.[doi:10.3969/j.issn.1006-1959.2018.22.045]
[4]高华初.奥美拉唑与西咪替丁治疗应激性胃溃疡的疗效观察[J].医学信息,2018,31(23):136.[doi:10.3969/j.issn.1006-1959.2018.23.039]
　GAO Hua-chu.Efficacy of Omeprazole and Cimetidine in the Treatment of Stress Gastric Ulcer[J].Journal of Medical Information,2018,31(23):136.[doi:10.3969/j.issn.1006-1959.2018.23.039]
[5]张宏程.磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床疗效观察[J].医学信息,2019,32(02):150.[doi:10.3969/j.issn.1006-1959.2019.02.044]
　ZHANG Hong-cheng.Clinical Efficacy of Aluminum Phosphate Gel Combined with Omeprazole in the Treatment of Peptic Ulcer[J].Journal of Medical Information,2019,32(23):150.[doi:10.3969/j.issn.1006-1959.2019.02.044]
[6]李会颖.奥美拉唑联合多潘立酮治疗哮喘合并胃食管反流病的效果[J].医学信息,2020,33(09):144.[doi:10.3969/j.issn.1006-1959.2020.09.047]
　LI Hui-ying.Effect of Omeprazole Combined with Domperidone on Asthma Combined with Gastroesophageal Reflux Disease[J].Journal of Medical Information,2020,33(23):144.[doi:10.3969/j.issn.1006-1959.2020.09.047]
[7]任 琳.雷尼替丁和奥美拉唑治疗浅表性胃炎的效果比较[J].医学信息,2020,33(12):141.[doi:10.3969/j.issn.1006-1959.2020.12.044]
　REN Lin.Ranitidine and Omeprazole in the Treatment of Superficial Gastritis[J].Journal of Medical Information,2020,33(23):141.[doi:10.3969/j.issn.1006-1959.2020.12.044]
[8]刘小娟.大剂量奥美拉唑治疗消化性溃疡出血的有效性与安全性[J].医学信息,2020,33(17):143.[doi:10.3969/j.issn.1006-1959.2020.17.041]
　LIU Xiao-juan.Efficacy and Safety of High-dose Omeprazole in the Treatment of Peptic Ulcer Bleeding[J].Journal of Medical Information,2020,33(23):143.[doi:10.3969/j.issn.1006-1959.2020.17.041]
[9]李 杰.奥美拉唑联合铝碳酸镁对反流性食管炎患者临床症状及血清胃泌素水平的影响[J].医学信息,2022,35(06):153.[doi:10.3969/j.issn.1006-1959.2022.06.039]
　LI Jie.Effect of Omeprazole Combined with Aluminum Magnesium Carbonate on Clinical Symptoms and Serum Gastrin Level in Patients with Reflux Esophagitis[J].Journal of Medical Information,2022,35(23):153.[doi:10.3969/j.issn.1006-1959.2022.06.039]
[10]陈艳玲.奥美拉唑、兰索拉唑与泮托拉唑治疗胃炎胃溃疡的效果及安全性[J].医学信息,2022,35(10):134.[doi:10.3969/j.issn.1006-1959.2022.10.032]
　CHEN Yan-ling.Effect and Safety of Omeprazole, Lansoprazole and Pantoprazole in the Treatment of Gastritis and Gastric Ulcer[J].Journal of Medical Information,2022,35(23):134.[doi:10.3969/j.issn.1006-1959.2022.10.032]

更新日期/Last Update: 1900-01-01