[1]王存波,柳旭丽,杨学秋,等.EGF、MMP-2、IL-6在白内障患者中的表达和意义[J].医学信息,2024,37(23):58-61.[doi:10.3969/j.issn.1006-1959.2024.23.013]
　WANG Cunbo,LIU Xuli,YANG Xueqiu,et al.Expression and Significance of EGF, MMP-2 and IL-6 in Cataract Patients[J].Journal of Medical Information,2024,37(23):58-61.[doi:10.3969/j.issn.1006-1959.2024.23.013]
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EGF、MMP-2、IL-6在白内障患者中的表达和意义()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年23期
页码:
58-61
栏目:
论著
出版日期:
2024-12-01

文章信息/Info

Title:
Expression and Significance of EGF, MMP-2 and IL-6 in Cataract Patients
文章编号:
1006-1959（2024）23-0058-04
作者:
王存波1; 柳旭丽 2; 杨学秋1; 吴 爽1
昌邑市人民医院眼科1，特检科2，山东 昌邑 261300
Author(s):
WANG Cunbo1; LIU Xuli2; YANG Xueqiu1; WU Shuang1
Department of Ophthalmology1,Department of Special Inspection2,Changyi People’s Hospital,Changyi 261300,Shandong,China
关键词:
EGF; MMP-2; IL-6; 白内障
Keywords:
EGF; MMP-2; IL-6; Cataract
分类号:
R776.1
DOI:
10.3969/j.issn.1006-1959.2024.23.013
文献标志码:
A
摘要:
目的 探讨白内障患者血清中EGF、MMP-2、IL-6的表达变化及意义。方法 选取2018年2月-2023年2月在昌邑市人民医院治疗的白内障患者60例作为试验组，同时选取同期来院体检的健康人群60例作为对照组。采用ELISA试验检测两组人群血清EGF、MMP-2、IL-6表达水平；探讨EGF、MMP-2、IL-6与白内障患者临床指标的关系，分析EGF与MMP-2、IL-6的相关性。结果 试验组血清EGF、MMP-2、IL-6水平高于对照组（P＜0.05）；EGF、MMP-2、IL-6的表达与裂隙灯下核混浊强度（NO）、核颜色（NC）、皮质的不透明区域（C）以及后囊区域的混浊（P）分级有关，与性别、年龄及白内障确诊时间无关（P＞0.05）；EGF与MMP-2（r=0.345，P=0.004）、IL-6（r=0.306，P=0.009）的表达呈正相关。结论 白内障患者血清EGF、MMP-2、IL-6表达存在异常，其中EGF的表达与MMP-2、IL-6的表达呈正相关，说明EGF、MMP-2、IL-6的表达异常参与了白内障的发生发展。
Abstract:
Objective To investigate the expression and significance of EGF, MMP-2 and IL-6 in serum of cataract patients.Methods A total of 60 patients with cataract treated in Changyi People’s Hospital from February 2018 to February 2023 were selected as the experimental group, and 60 healthy people who came to the hospital for physical examination during the same period were selected as the control group. The expression levels of serum EGF, MMP-2 and IL-6 in the two groups were detected by ELISA. And the relationship between EGF, MMP-2, IL-6 and clinical indexes of cataract patients was investigated, andthe correlation between EGF and MMP-2, IL-6was analyzed.Results The serum levels of EGF, MMP-2 and IL-6 in the experimental group were higher than those in the control group (P<0.05).The expression of EGF, MMP-2 and IL-6 was related to the nuclear opacity intensity (NO), nuclear color (NC), opaque area of cortex (C) and opacity (P) grade of posterior capsule area under slit lamp, but not related to gender and age (P>0.05). The expression of EGF was positively correlated with that of MMP-2 (r=0.345, P=0.004) and IL-6 (r=0.306, P=0.009).Conclusion The expression of serum EGF, MMP-2 and IL-6 in patients with cataract is abnormal, and the expression of EGF is positively correlated with the expression of MMP-2 and IL-6, indicating that the abnormal expression of EGF, MMP-2 and IL-6 is involved in the occurrence and development of cataract.

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更新日期/Last Update: 1900-01-01