[1]卢伟凤.头孢唑啉钠与甲硝唑联用对子宫肌瘤患者腹腔镜剔除术后切口感染的预防效果观察[J].医学信息,2024,37(24):41-43,51.[doi:10.3969/j.issn.1006-1959.2024.24.011]
　LU Weifeng.Preventive Effect of Cefazolin Sodium Combined with Metronidazole on Incision Infection After Laparoscopic Myomectomy in Patients with Uterine Fibroids[J].Journal of Medical Information,2024,37(24):41-43,51.[doi:10.3969/j.issn.1006-1959.2024.24.011]
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头孢唑啉钠与甲硝唑联用对子宫肌瘤患者腹腔镜剔除术后切口感染的预防效果观察()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年24期
页码:
41-43,51
栏目:
论著
出版日期:
2024-12-15

文章信息/Info

Title:
Preventive Effect of Cefazolin Sodium Combined with Metronidazole on Incision Infection After Laparoscopic Myomectomy in Patients with Uterine Fibroids
文章编号:
1006-1959（2024）24-0041-04
作者:
卢伟凤
进贤县人民医院妇产科，江西 进贤 334400
Author(s):
LU Weifeng
Obstetrics and Gynecology Department of Jinxian County People’s Hospital,Jinxian 334400,Jiangxi,China
关键词:
头孢唑啉钠; 甲硝唑; 子宫肌瘤; 腹腔镜剔除术; 切口感染
Keywords:
Cefazolin sodium; Metronidazole; Uterine fibroids; Laparoscopic myomectomy; Incision infection
分类号:
R969
DOI:
10.3969/j.issn.1006-1959.2024.24.011
摘要:
目的 探究头孢唑啉钠与甲硝唑联用对子宫肌瘤患者腹腔镜剔除术后切口感染的预防效果。方法 选取2021年7月-2023年6月我院收治的60例子宫肌瘤腹腔镜剔除术患者作为研究对象，按照随机数字表法将所有患者分为对照组与研究组，每组30例。对照组采取甲硝唑治疗，研究组采取头孢唑啉钠联合甲硝唑治疗。比较两组患者的血清氧化应激水平[丙二醛（MDA）、超氧化物歧化酶（SOD）、一氧化氮（NO）、血浆内皮素 -1（ET-1）]、切口生长状况（切口肉芽组织增生程度、切口渗出范围）、血清炎性因子水平[肿瘤坏死因子（TNF）-α、C-反应蛋白（CRP）、白细胞介素（IL）-8]。结果 两组治疗后MDA、ET-1水平降低，SOD、NO水平升高，且研究组MDA、ET-1 水平低于对照组，SOD、NO水平高于对照组（P＜0.05）。两组治疗后切口肉芽组织增生评分、切口渗出范围评分均低于治疗前，且研究组切口肉芽组织增生评分、切口渗出范围评分低于对照组（P＜0.05）。两组治疗后TNF-α、CRP、IL-8水平均低于治疗前，且研究组TNF-α、CRP、IL-8水平低于对照组（P＜0.05）。结论 头孢唑啉钠联合甲硝唑用于子宫肌瘤患者腹腔镜剔除术后抗感染治疗，可促进术后感染切口愈合，减轻血清炎性因子水平，改善机体的氧化应激反应，值得临床应用。
Abstract:
Objective To explore the preventive effect of cefazolin sodium combined with metronidazole on incision infection after laparoscopic myomectomy in patients with uterine fibroids.Methods From July 2021 to June 2023, 60 patients with laparoscopic myomectomy admitted to our hospital were selected as the research objects. According to the random number table method, all patients were divided into control group and study group, with 30 patients in each group. The control group was treated with metronidazole, and the study group was treated with cefazolin sodium combined with metronidazole. The serum oxidative stress levels [malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), plasma endothelin-1 (ET-1)], incision growth status (incision granulation tissue hyperplasia degree, incision exudation range), serum inflammatory factor levels [tumor necrosis factor (TNF)-α, C-reactive protein (CRP), interleukin (IL)-8 ] were compared between the two groups.Results After treatment, the levels of MDA and ET-1 in the two groups decreased, and the levels of SOD and NO increased, while the levels of MDA and ET-1 in the study group were lower than those in the control group, and the levels of SOD and NO were higher than those in the control group (P<0.05). After treatment, the scores of granulation tissue hyperplasia and incision exudation range in the two groups were lower than those before treatment, and the scores of granulation tissue hyperplasia and incision exudation range in the study group were lower than those in the control group (P<0.05). After treatment, the levels of TNF-α, CRP and IL-8 in the two groups were lower than those before treatment, and the levels of TNF-α, CRP and IL-8 in the study group were lower than those in the control group (P<0.05).Conclusion Cefazolin sodium combined with metronidazole for anti-infection treatment after laparoscopic myomectomy in patients with uterine fibroids can promote the healing of postoperative infection incision, reduce the level of serum inflammatory factors, and improve the body’s oxidative stress response, which is worthy of clinical application.

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更新日期/Last Update: 1900-01-01