[1]许清香.雌激素联合甲硝唑治疗老年阴道炎患者的疗效[J].医学信息,2022,35(18):115-117.[doi:10.3969/j.issn.1006-1959.2022.18.031]
　XU Qing-xiang.Efficacy of Estrogen Combined with Metronidazole in the Treatment of Elderly Patients with Vaginitis[J].Journal of Medical Information,2022,35(18):115-117.[doi:10.3969/j.issn.1006-1959.2022.18.031]
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雌激素联合甲硝唑治疗老年阴道炎患者的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年18期
页码:
115-117
栏目:
药物与临床
出版日期:
2022-09-15

文章信息/Info

Title:
Efficacy of Estrogen Combined with Metronidazole in the Treatment of Elderly Patients with Vaginitis
文章编号:
1006-1959（2022）18-0115-03
作者:
许清香
（石城县中医院妇产科，江西 石城 342700）
Author(s):
XU Qing-xiang
(Department of Obstetrics and Gynaecology,Shicheng County Hospital of Traditional Chinese Medicine,Shicheng 342700,Jiangxi,China)
关键词:
阴道炎; 雌激素; 甲硝唑; 雌二醇
Keywords:
Vaginitis; Estrogen; Metronidazole; Estradiol
分类号:
R711.31
DOI:
10.3969/j.issn.1006-1959.2022.18.031
文献标志码:
A
摘要:
目的 观察雌激素联合甲硝唑对老年阴道炎患者的临床疗效。方法 选取2018年10月-2020年10月我院收治的60例老年阴道炎患者，随机分为对照组和观察组，每组30例。对照组予以甲硝唑治疗，观察组予以雌激素联合甲硝唑治疗，比较两组临床疗效、阴道健康评分（VHS）、血清雌二醇（E2）、血清卵泡刺激素（FSH）、炎性因子[C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）]、子宫内膜厚度、复发情况。结果 观察组治疗总有效率为96.67%，高于对照组的83.33%（P＜0.05）；观察组VHS评分高于对照组（P＜0.05）；观察组E2水平高于对照组，FSH水平低于对照组（P＜0.05）；观察组CRP、TNF-α、IL-6水平低于对照组（P＜0.05）；两组治疗前后子宫内膜厚度比较，差异无统计学意义（P＞0.05），但观察组30 d复发率低于对照组（P＜0.05）。结论 雌激素联合甲硝唑治疗老年阴道炎的疗效肯定，可改善阴道健康，调节性激素水平，抑制炎性反应，且不刺激子宫内膜增生，复发率低。
Abstract:
Objective To observe the clinical efficacy of estrogen combined with metronidazole in elderly patients with vaginitis.Methods Sixty elderly patients with vaginitis admitted to our hospital from October 2018 to October 2020 were randomly divided into control group and observation group, with 30 cases in each group. The control group was treated with metronidazole, and the observation group was treated with estrogen combined with metronidazole. The clinical efficacy, vaginal health score (VHS), serum estradiol (E2), serum follicle stimulating hormone (FSH), inflammatory factors [C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)], endometrial thickness and recurrence were compared between the two groups.Results The total effective rate of treatment in the observation group was 96.67%, which was higher than 83.33% in the control group (P<0.05). The VHS score of the observation group was higher than that of the control group (P<0.05). The level of E2 in the observation group was higher than that in the control group, and the level of FSH was lower than that in the control group (P<0.05). The levels of CRP, TNF-α and IL-6 in the observation group were lower than those in the control group (P<0.05). There was no significant difference in endometrial thickness between the two groups before and after treatment (P>0.05), but the 30 d recurrence rate in the observation group was lower than that in the control group (P<0.05). Conclusion Estrogen combined with metronidazole is effective in the treatment of senile vaginitis. It can improve vaginal health, regulate sex hormone levels, inhibit inflammatory response, and does not stimulate endometrial hyperplasia, with low recurrence rate.

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更新日期/Last Update: 1900-01-01