[1]陈金荣.TRAb、TSH、IFN-γ和IL-17水平变化在甲状腺功能亢进患者诊断中的应用[J].医学信息,2024,37(24):155-158.[doi:10.3969/j.issn.1006-1959.2024.24.042]
　CHEN Jinrong.Application of TRAb, TSH, IFN-γ and IL-17 Levels in the Diagnosis of Patients with Hyperthyroidism[J].Journal of Medical Information,2024,37(24):155-158.[doi:10.3969/j.issn.1006-1959.2024.24.042]
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TRAb、TSH、IFN-γ和IL-17水平变化在甲状腺功能亢进患者诊断中的应用()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
37卷
期数:
2024年24期
页码:
155-158
栏目:
诊疗技术
出版日期:
2024-12-15

文章信息/Info

Title:
Application of TRAb, TSH, IFN-γ and IL-17 Levels in the Diagnosis of Patients with Hyperthyroidism
文章编号:
1006-1959（2024）24-0155-04
作者:
陈金荣
罗定市人民医院内分泌肾内科，广东 罗定 527200
Author(s):
CHEN Jinrong
Department of Endocrinology and Nephrology,Luoding People’s Hospital,Luoding 527200,Guangdong,China
关键词:
TRAb; TSH; IFN-γ; IL-17; 甲状腺功能亢进
Keywords:
TRAb; TSH; IFN-γ; IL-17; Hyperthyroidism
分类号:
R446
DOI:
10.3969/j.issn.1006-1959.2024.24.042
摘要:
目的 探究促甲状腺激素受体抗体（TRAb）、促甲状腺激素（TSH）及干扰素（IFN）-γ、白细胞介素（IL）-17水平变化在甲状腺功能亢进患者诊断中的应用效果。方法 选取2018年10月-2022年9月罗定市人民医院收治的疑似甲状腺功能亢进患者506例作为研究组，选取同一时间段内该院健康体检者150例作为对照组。比较两组TRAb、TSH、IFN-γ和IL-17水平，以病理诊断结果作为检测“金标准”，分析不同指标诊断甲状腺功能亢进的灵敏度、特异度、阳性预测值、阴性预测值、准确率、漏诊率、误诊率。结果 研究组TRAb、IL-17水平高于对照组，TSH、IFN-γ水平低于对照组（P＜0.05）。TRAb、TSH、IFN-γ和IL-17水平联合检测诊断甲状腺功能亢进的灵敏度、特异度、阳性预测值、阴性预测值、准确率均高于上述指标单独检测，且漏诊率、误诊率低于单独检测（P＜0.05）。结论 TRAb、TSH、IFN-γ和IL-17水平变化在甲状腺功能亢进患者诊断中的应用效果确切，便于评估患者病情状况，为后期治疗提供准确参考依据。
Abstract:
Objective To explore the application effect of changes of thyroid stimulating hormone receptor antibody (TRAb), thyroid stimulating hormone (TSH), interferon (IFN)-γ and interleukin (IL)-17 levels in the diagnosis of patients with hyperthyroidism.Methods A total of 506 patients with suspected hyperthyroidism admitted to Luoding People’s Hospital from October 2018 to September 2022 were selected as the study group, and 150 healthy subjects in the hospital during the same period were selected as the control group. The levels of TRAb, TSH, IFN-γ and IL-17 were compared between the two groups. The pathological diagnosis results were used as the gold standard for detection, the sensitivity, specificity, positive predictive value, negative predictive value, accuracy, missed diagnosis rate and misdiagnosis rate of different indicators in the diagnosis of hyperthyroidism were analyzed.Results The levels of TRAb and IL-17 in the study group were higher than those in the control group, and the levels of TSH and IFN-γ were lower than those in the control group (P<0.05). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of combined detection of TRAb, TSH, IFN-γ and IL-17 levels in the diagnosis of hyperthyroidism were higher than those of the above indexes alone, and the missed diagnosis rate and misdiagnosis rate were lower than those of the above indexes alone (P<0.05).Conclusion The changes of TRAb, TSH, IFN-γ and IL-17 levels are effective in the diagnosis of patients with hyperthyroidism. It is convenient to evaluate the condition of patients and provide accurate reference for later treatment.

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更新日期/Last Update: 1900-01-01