[1]张 程,李 程,曹一南.探索双硫死亡相关长链非编码RNA在乳腺癌中的预后价值并构建风险模型[J].医学信息,2025,38(01):37-43.[doi:10.3969/j.issn.1006-1959.2025.01.006]
　ZHANG Cheng,LI Cheng,CAO Yinan.Prognostic Value of Disulfidoptosis-related Long Non-coding RNA in Breast Cancer and Construct a Risk Model[J].Journal of Medical Information,2025,38(01):37-43.[doi:10.3969/j.issn.1006-1959.2025.01.006]
点击复制

探索双硫死亡相关长链非编码RNA在乳腺癌中的预后价值并构建风险模型()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年01期
页码:
37-43
栏目:
临床信息学
出版日期:
2025-01-01

文章信息/Info

Title:
Prognostic Value of Disulfidoptosis-related Long Non-coding RNA in Breast Cancer and Construct a Risk Model
文章编号:
1006-1959（2025）01-0037-07
作者:
张 程; 李 程; 曹一南
南京卫生高等职业技术学校医学技术系，江苏 南京 210000
Author(s):
ZHANG Cheng;  LI Cheng;  CAO Yi′nan
Department of Medical Technology, Nanjing Vocational Health College, Nanjing 210000, Jiangsu, China
关键词:
乳腺癌; 双硫死亡; 长链非编码RNA; 预后模型
Keywords:
Breast cancer;  Disulfidptosis;  Long non-coding RNA;  Prognostic model
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2025.01.006
文献标志码:
A
摘要:
目的 构建与双硫死亡相关长链非编码RNA（DRL）风险评分。方法 从癌症基因组图谱TCGA数据库中下载乳腺癌的转录组数据，使用Perl脚本提取患者的lincRNA数据，通过Sperman相关性分析识别与双硫死亡相关的lincRNA，通过单因素和LASSO多因素Cox回归分析识别独立预后的DRLs并构建风险评分。结果 单因素和LASSO多因素回归分析共筛选出了13个DRLs用于构建风险评分。卡普兰-迈耶（KM）曲线和受试者工作特征（ROC）曲线表明风险评分具有较好的预测性能。此外，不同风险组患者的临床病理特征、富集分析和药物敏感性也存在显著差异。基于风险评分构建了预测乳腺癌患者3年和5年总生存期（OS）的列线图预测模型，C指数、ROC曲线和校准曲线表明模型具有较为出色的预测性能。结论 本研究构建了与DRLs相关的预后模型，有助于评估乳腺癌患者的预后，并为临床治疗决策提供一定的参考。
Abstract:
Objective To construct a risk score of disulfidoptosis-related long non-coding RNA (DRL). Methods The transcriptome data of breast cancer were downloaded from the cancer genome atlas TCGA database, and the lincRNA data of patients were extracted by Perl script. The disulfidoptosis-related long non-coding RNA was identified by Sperman correlation analysis, and the independent prognostic DRLs were identified by univariate and LASSO multivariate Cox regression analysis, and the risk score was constructed. Results A total of 13 DRLs were selected for risk score construction by univariate and LASSO multivariate regression analysis. Kaplan-Meier (KM) curve and receiver operating characteristic (ROC) curve showed that the risk score had good predictive performance. In addition, there were significant differences in clinicopathological features, enrichment analysis and drug sensitivity among patients in different risk groups. Based on the risk score, a nomogram prediction model was constructed to predict the 3-year and 5-year overall survival (OS) of breast cancer patients, and the C index, ROC curve and calibration curve showed that the model had excellent prediction performance. Conclusion This study constructed a prognostic model related to DRLs, which is helpful to evaluate the prognosis of breast cancer patients and provide some reference for clinical treatment decisions.

参考文献/References:

[1]Sung H,Ferlay J,Siegel RL,et al.Global Cancer Statistics 2020:GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries[J].CA Cancer J Clin,2021,71(3):209-249.[2]Nagaraj G,Ma CX.Clinical Challenges in the Management of Hormone Receptor-Positive,Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer:A Literature Review[J].Adv Ther,2021,38(1):109-136.[3]Cardoso F,Kyriakides S,Ohno S,et al.Early breast cancer:ESMO Clinical Practice Guidelines for diagnosis,treatment and follow-up[J].Ann Oncol,2019,30(10):1674.[4]Chen Y,Li Z,Chen X,et al.Long non-coding RNAs:From disease code to drug role[J].Acta Pharm Sin B,2021,11(2):340-354.[5]Song X,Liu Z,Yu Z.LncRNA NEF is downregulated in triple negative breast cancer and correlated with poor prognosis[J].Acta Biochim Biophys Sin(Shanghai),2019,51(4):386-392.[6]Zhu L,Wang F,Fan W,et al.lncRNA NEAT1 promotes the Taxol resistance of breast cancer via sponging the miR-23a-3p-FOXA1 axis[J].Acta Biochim Biophys Sin(Shanghai),2021,53(9):1198-1206.[7]Liu X,Nie L,Zhang Y,et al.Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis[J].Nat Cell Biol,2023,25(3):404-414.[8]Zhao D,Meng Y,Dian Y,et al.Molecular landmarks of tumor disulfidptosis across cancer types to promote disulfidptosis-target therapy[J].Redox Biol,2023,68:102966.[9]Wang X,Lin J,Li Z,et al.In what area of biology has a “new” type of cell death been discovered[J].Biochim Biophys Acta Rev Cancer,2023,1878(5):188955.[10]Maeser D,Gruener RF,Huang RS.oncoPredict:an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data[J].Brief Bioinform,2021,22(6):bbab260.[11]张思维,郑荣寿,孙可欣,等.2016年中国恶性肿瘤分地区发病和死亡估计:基于人群的肿瘤登记数据分析[J].中国肿瘤,2023,32(5):321-332.[12]Rakha EA,Ellis IO.Modern classification of breast cancer: should we stick with morphology or convert to molecular profile characteristics[J].Adv Anat Pathol,2011,18(4):255-267.[13]Diaz LK,Cryns VL,Symmans WF,et al.Triple negative breast carcinoma and the basal phenotype:from expression profiling to clinical practice[J].Adv Anat Pathol,2007,14(6):419-430.[14]Early Breast Cancer Trialists’ Collaborative Group(EBCTCG).Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials[J].Lancet,2023,402(10416):1991-2003.[15]Chang CA,Jen J,Jiang S,et al.Ontogeny and Vulnerabilities of Drug-Tolerant Persisters in HER2+ Breast Cancer[J].Cancer Discov,2022,12(4):1022-1045.[16]Zheng P,Zhou C,Ding Y,et al.Disulfidptosis:a new target for metabolic cancer therapy[J].J Exp Clin Cancer Res,2023,42(1):103.[17]Hadian K,Stockwell BR.The therapeutic potential of targeting regulated non-apoptotic cell death[J].Nat Rev Drug Discov,2023,22(9):723-742.[18]Wang Z,Chen X,Zhang J,et al.Based on disulfidptosis-related glycolytic genes to construct a signature for predicting prognosis and immune infiltration analysis of hepatocellular carcinoma[J].Front Immunol,2023,14:1204338.[19]Chi H,Huang J,Yan Y,et al.Unraveling the role of disulfidptosis-related LncRNAs in colon cancer:a prognostic indicator for immunotherapy response,chemotherapy sensitivity,and insights into cell death mechanisms[J].Front Mol Biosci,2023,10:1254232.[20]Liu T,Ren Y,Wang Q,et al.Exploring the role of the disulfidptosis-related gene SLC7A11 in adrenocortical carcinoma:implications for prognosis,immune infiltration,and therapeutic strategies[J].Cancer Cell Int,2023,23(1):259.

相似文献/References:

[1]董 云.SPECT/CT 双时相99mTc- MIBI断层显像 在乳腺癌诊断中的应用[J].医学信息,2018,31(05):147.[doi:10.3969/j.issn.1006-1959.2018.05.053]
　DONG Yun.Application of SPECT/CT Dual-phase 99mTc-MIBI Tomography in the Diagnosis of Breast Cancer[J].Journal of Medical Information,2018,31(01):147.[doi:10.3969/j.issn.1006-1959.2018.05.053]
[2]张 虎,张 涛,徐 芳,等.MRI在乳腺癌诊治中的研究进展[J].医学信息,2022,35(10):62.[doi:10.3969/j.issn.1006-1959.2022.10.015]
　ZHANG Hu,ZHANG Tao,XU Fang,et al.Research Progress of MRI in Diagnosis and Treatment of Breast Cancer[J].Journal of Medical Information,2022,35(01):62.[doi:10.3969/j.issn.1006-1959.2022.10.015]
[3]李建辉,祝旭龙.乳腺癌的治疗管理——把好生活质量关[J].医学信息,2018,31(13):1.[doi:10.3969/j.issn.1006-1959.2018.13.001]
[4]杨玉峰,李 强,曲国红,等.乳腺癌术前巴德枪穿刺检测ER、PR的临床研究[J].医学信息,2018,31(13):163.[doi:10.3969/j.issn.1006-1959.2018.13.050]
　YANG Yu-feng,LI Qiang,QU Guo-hong,et al.Clinical Study on Preoperative ER and PR Detection of Bard Gun Puncture in Breast Cancer[J].Journal of Medical Information,2018,31(01):163.[doi:10.3969/j.issn.1006-1959.2018.13.050]
[5]刘雪静,路 红,徐熠琳,等.乳腺影像与容积导航技术初步应用的临床分析[J].医学信息,2022,35(11):161.[doi:10.3969/j.issn.1006-1959.2022.11.043]
　LIU Xue-jing,LU Hong,XU Yi-lin,et al.Clinical Analysis of the Preliminary Application of Breast Imaging and Volume Navigation Technology[J].Journal of Medical Information,2022,35(01):161.[doi:10.3969/j.issn.1006-1959.2022.11.043]
[6]刘在波,修文娟.背阔肌皮瓣联合假体在乳腺癌改良根治术后乳房重建中的应用[J].医学信息,2019,32(02):127.[doi:10.3969/j.issn.1006-1959.2019.02.036]
　LIU Zai-bo,XIU Wen-juan.Application of Latissimus Dorsi Flap Combined with Prosthesis in Breast Reconstruction after Modified Radical Mastectomy for Breast Cancer[J].Journal of Medical Information,2019,32(01):127.[doi:10.3969/j.issn.1006-1959.2019.02.036]
[7]孟庆国,王佳雪,王斯佳.马来酸吡咯替尼对乳腺癌术后患者心脏功能的影响[J].医学信息,2019,32(02):152.[doi:10.3969/j.issn.1006-1959.2019.02.045]
　MENG Qing-guo,WANG Jia-xue,WANG Si-jia.Effect of Pyrrolidine Maleate on Cardiac Function in Patients after Breast Cancer Operation[J].Journal of Medical Information,2019,32(01):152.[doi:10.3969/j.issn.1006-1959.2019.02.045]
[8]刘 曼,厉玛倩倩,徐润润,等.延续性护理对乳腺癌术后化疗患者生活质量与 健康知识水平的影响[J].医学信息,2018,31(16):178.[doi:10.3969/j.issn.1006-1959.2018.16.057]
　LIU Man,LIMA Qian-qian,XU Run-run,et al.Effect of Continuous Nursing on Quality of Life and Health Knowledge of Postoperative Chemotherapy Patients with Breast Cancer[J].Journal of Medical Information,2018,31(01):178.[doi:10.3969/j.issn.1006-1959.2018.16.057]
[9]满枋霖,葛俊宏,林晓月,等.p21活化激酶在乳腺癌中的作用研究[J].医学信息,2019,32(06):35.[doi:10.3969/j.issn.1006-1959.2019.06.013]
　MAN Fang-lin,GE Jun-hong,LIN Xiao-yue,et al.The Role of p21 Activated Kinase in Breast Cancer[J].Journal of Medical Information,2019,32(01):35.[doi:10.3969/j.issn.1006-1959.2019.06.013]
[10]张天竺,宁 勇.长链非编码RNA调控乳腺癌发生发展的研究进展[J].医学信息,2019,32(12):40.[doi:10.3969/j.issn.1006-1959.2019.12.014]
　ZHANG Tian-zhu,NING Yong.Advances in Research on Long-chain Non-coding RNA Regulation of Breast Cancer Development[J].Journal of Medical Information,2019,32(01):40.[doi:10.3969/j.issn.1006-1959.2019.12.014]

更新日期/Last Update: 1900-01-01