[1]郭君健.2018-2023年某医院住院患儿EB病毒感染情况及流行病学分析[J].医学信息,2025,38(09):74-77.[doi:10.3969/j.issn.1006-1959.2025.09.013]
 GUO Junjian.Prevalence and Epidemiological Characteristics of EB Virus Infection in Hospitalized Children in a Hospital from 2018 to 2023[J].Journal of Medical Information,2025,38(09):74-77.[doi:10.3969/j.issn.1006-1959.2025.09.013]
点击复制

2018-2023年某医院住院患儿EB病毒感染情况及流行病学分析()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年09期
页码:
74-77
栏目:
公共卫生信息学
出版日期:
2025-05-01

文章信息/Info

Title:
Prevalence and Epidemiological Characteristics of EB Virus Infection in Hospitalized Children in a Hospital from 2018 to 2023
文章编号:
1006-1959(2025)09-0074-04
作者:
郭君健
三峡大学附属仁和医院检验科,湖北 宜昌 443001
Author(s):
GUO Junjian
Department of Clinical Laboratory, Affiliated Renhe Hospital of China Three Gorges University, Yichang 443001, Hubei, China
关键词:
EB病毒住院患儿流行病学
Keywords:
EB virus Hospitalized children Epidemiology
分类号:
R725.1
DOI:
10.3969/j.issn.1006-1959.2025.09.013
文献标志码:
A
摘要:
目的 了解住院患儿EB病毒感染情况及流行病学特征,为临床对EB病毒感染的诊断和治疗工作提供科学依据。方法 选取2018年1月-2023年12月在三峡大学附属仁和医院住院治疗的9960例患儿作为研究对象,采用ELISA检测EB病毒血清学抗体,分析患儿EB病毒感染情况及其疾病谱、临床症状和体征构成比。结果 在9960份血液标本中,其中7083例(71.11%)抗体谱提示EB病毒感染,包括现症感染971例(9.75%)、亚急性感染1305例(13.10%)、既往感染4807例(48.26%);男性4720份标本,检出阳性例数3323例,女性5240份标本,检出阳性例数3760例,男、女阳性率分别为70.40%、71.76%;感染者年龄段中EB病毒阳性率最高的是3~6岁,在3150份血液标本中,检出EB病毒阳性例数2763例,阳性率为87.71%;971例现症感染患儿的疾病谱中,传染性单核细胞增多症患者357例,占比为36.77%;其次为急性支气管炎患儿244例,占比为25.13%;临床症状及体征构成比中,表现为发热的患儿最多(505例),占比为52.01%;其次为咳嗽咳痰的患儿(215例),占比为22.14%。结论 住院患儿EB病毒感染率较高,EB病毒阳性检出率有年龄差异,现症感染以传染性单核细胞增多症患儿为主,临床症状及体征以发热较为多见,医院应根据流学病学特征制定相应预防措施。
Abstract:
Objective To understand the prevalence and epidemiological characteristics of EB virus infection in hospitalized children, and to provide a scientific basis for clinical diagnosis and treatment of EB virus infection. Methods A total of 9960 children who were hospitalized in Affiliated Renhe Hospital of China Three Gorges University from January 2018 to December 2023 were selected as the research objects. ELISA was used to detect EB virus serological antibodies, and the EB virus infection, disease spectrum, clinical symptoms and signs were analyzed. Results Among the 9960 blood samples, 7083 (71.11%) samples of the antibody profiles indicated EB virus infection, including 971 (9.75%) samples were current infections, 1305 (13.10%) samples were subacute infections, and 4807 (48.26%) samples were previous infections. There were 3323 positive cases in 4720 male specimens and 3760 positive cases in 5240 female specimens. The positive rates of male and female were 70.40% and 71.76%, respectively. The highest positive rate of EB virus in the infected age group was 3-6 years old. Among 3150 blood samples, 2763 cases of EB virus positive were detected, with a positive rate of 87.71%. In the disease spectrum of 971 children with current infection, there were 357 patients with infectious mononucleosis, accounting for 36.77%; followed by 244 cases of acute bronchitis, accounting for 25.13%; among the constituent ratio of clinical symptoms and signs, children with fever were the most (505 cases), accounting for 52.01%; followed by children with cough and expectoration (215 cases), accounting for 22.14%. Conclusion The infection rate of EB virus in hospitalized children is high, and the positive detection rate of EB virus has age difference. The current infection is mainly in children with infectious mononucleosis. The clinical symptoms and signs are more common in fever. The hospital should formulate corresponding preventive measures according to the characteristics of epidemiology.

参考文献/References:

[1]刘军,邓世明,刘铁陵,等.EB病毒的生物学特点及致病机制[J].病毒学报,2024,40(4):887-896.[2]田军.EB病毒DNA检测与儿童传染性单核细胞增多症相关性研究[J].中国优生与遗传杂志,2020,28(9):1146-1148.[3]Chen S,Wei A,Ma H,et al.Clinical Features and Prognostic Factors of Children with Chronic Active Epstein-Barr Virus Infection: A Retrospective Analysis of a Single Center[J].J Pediatr,2021,238:268-274.e2.[4]Zhang Q,Wei A,Ma HH,et al.A pilot study of ruxolitinib as a front-line therapy for 12 children with secondary hemophagocytic lymphohistiocytosis[J].Haematologica,2021,106(7):1892-1901.[5]Murata T,Sugimoto A,Inagaki T,et al.Molecular Basis of Epstein-Barr Virus Latency Establishment and Lytic Reactivation[J].Viruses,2021,13(12):2344.[6]闫江泓,贾莉,李文辉,等.河北省儿童医院住院患儿EB病毒感染流行病学特征[J].检验医学,2020,35(4):323-326.[7]朱元璐,黄琴,余忠红.2013-2018年德阳市医院感染性儿童患者EB病毒感染情况分析[J].预防医学情报杂志,2019,35(4):346-349,353.[8]Kuri A,Jacobs BM,Vickaryous N,et al.Epidemiology of Epstein-Barr virus infection and infectious mononucleosis in the United Kingdom[J].BMC Public Health,2020,20(1):912.[9]Ye Z,Chen L,Zhong H,et al.Epidemiology and clinical characteristics of Epstein-Barr virus infection among children in Shanghai, China, 2017-2022[J].Front Cell Infect Microbiol,2023,13:1139068.[10]王萌萌,梁日文,孔凡虹,等.深圳市罗湖区儿童EB病毒感染情况及流行病学分析[J].临床检验杂志,2020,38(4):310-312.[11]夏欢,洪云,赵庆珠,等.儿童EBV和CMV不同模式感染相关单核细胞增多症的临床和实验室检查特征分析[J].西部医学,2024,36(6):885-888,894.[12]刘瑞清,王军,张玉凤,等.不同年龄分期儿童传染性单核细胞增多症的临床分析[J].检验医学与临床,2023,20(18):2638-2644.[13]Topp SK,Rosenfeldt V,Vestergaard H,et al.Clinical characteristics and laboratory findings in Danish children hospitalized with primary Epstein-Barr virus infection[J].Infect Dis (Lond),2015,47(12):908-914.[14]郑文彬,熊小丽,汤建桥,等.EB病毒感染相关儿童传染性单核细胞增多症并发肺炎的危险因素[J].中华医院感染学杂志,2024,34(6):917-920.[15]Liu M,Wang X,Zhang L,et al.Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study[J].Virol Sin,2022,37(5):637-645.[16]陈建琴,吴建刚,王朝晖,等.EB病毒伴肺炎支原体感染致IM的临床特征及发病的危险因素分析[J].中国病原生物学杂志,2022,17(3):344-347.[17]彭启迪,闫波,胡波,等.传染性单核细胞增多症合并多种病原体感染的临床特点及淋巴细胞亚群变化特点分析[J].安徽医科大学学报,2021,56(12):2000-2003.[18]黄象维,王红,徐霞,等.儿童传染性单核细胞增多症与急性化脓性扁桃体炎早期鉴别指标及相关性分析[J].中华全科医学,2023,21(10):1698-1701,1748.[19]闫岩,袁云龙.儿童传染性单核细胞增多症临床及实验室检查特点分析[J].标记免疫分析与临床,2023,30(8):1316-1320.[20]解换弟,陈景,刘莎莎,等.儿童传染性单核细胞增多症常见实验室检查及临床症状的分析[J].广州医药,2021,52(1):116-119.

相似文献/References:

[1]高振亮,于 水,彭 冲,等.青岛地区住院患儿EB病毒感染状况分析[J].医学信息,2018,31(18):98.[doi:10.3969/j.issn.1006-1959.2018.18.030]
 GAO Zhen-liang,YU Shui,PENG Chong,et al.Analysis of Epstein-barr Virus Infection Status in Hospitalized Children in Qingdao Area[J].Journal of Medical Information,2018,31(09):98.[doi:10.3969/j.issn.1006-1959.2018.18.030]
[2]王兆辉,罗荣华,王绪栋,等.泰安市中心医院儿童大叶肺炎病原学特点及临床分析[J].医学信息,2018,31(22):133.[doi:10.3969/j.issn.1006-1959.2018.22.038]
 WANG Zhao-hui,LUO Rong-hua,WANG Xu-dong,et al.Pathogenic and Clinical Analysis of Children's Lobar Pneumonia in Central Hospital of Tai'an City[J].Journal of Medical Information,2018,31(09):133.[doi:10.3969/j.issn.1006-1959.2018.22.038]
[3]王小鹏,王美怡,刘 芬.EB病毒相关性传染性单核细胞增多症患儿并发肝功能异常的高危因素分析[J].医学信息,2022,35(14):66.[doi:10.3969/j.issn.1006-1959.2022.14.014]
 WANG Xiao-peng,WANG Mei-yi,LIU Fen.Analysis of Risk Factors for Liver Dysfunction in Children with EB Virus Infectious Mononucleosis[J].Journal of Medical Information,2022,35(09):66.[doi:10.3969/j.issn.1006-1959.2022.14.014]
[4]郑凌云.儿童传染性单核细胞增多症临床特点[J].医学信息,2020,33(02):118.[doi:10.3969/j.issn.1006-1959.2020.02.034]
 ZHENG Ling-yun.Clinical Characteristics of Childhood Infectious Mononucleosis[J].Journal of Medical Information,2020,33(09):118.[doi:10.3969/j.issn.1006-1959.2020.02.034]
[5]刘 敏,叶春晖.EB病毒与慢性阻塞性肺疾病的关系及其防治研究[J].医学信息,2020,33(04):32.[doi:10.3969/j.issn.1006-1959.2020.04.011]
 LIU Min,YE Chun-hui.Study on the Relationship between Epstein-Barr Virus and Chronic Obstructive Pulmonary Disease and its prevention[J].Journal of Medical Information,2020,33(09):32.[doi:10.3969/j.issn.1006-1959.2020.04.011]
[6]晏建国,罗 萍,胡 飞,等.多发性骨髓瘤患者EB病毒检测及其临床意义[J].医学信息,2021,34(15):86.[doi:10.3969/j.issn.1006-1959.2021.15.022]
 YAN Jian-guo,LUO Ping,HU Fei,et al.Detection of Epstein-Barr Virus in Patients with Multiple Myeloma and Its Clinical Significance[J].Journal of Medical Information,2021,34(09):86.[doi:10.3969/j.issn.1006-1959.2021.15.022]

更新日期/Last Update: 1900-01-01