[1]郑凌云.儿童传染性单核细胞增多症临床特点[J].医学信息,2020,33(02):118-120.[doi:10.3969/j.issn.1006-1959.2020.02.034]
　ZHENG Ling-yun.Clinical Characteristics of Childhood Infectious Mononucleosis[J].Medical Information,2020,33(02):118-120.[doi:10.3969/j.issn.1006-1959.2020.02.034]
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儿童传染性单核细胞增多症临床特点()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年02期
页码:
118-120
栏目:
临床研究
出版日期:
2020-01-15

文章信息/Info

Title:
Clinical Characteristics of Childhood Infectious Mononucleosis
文章编号:
1006-1959（2020）02-0118-03
作者:
郑凌云
（天津市宝坻区人民医院/天津医科大学宝坻临床学院儿科，天津 301800）
Author(s):
ZHENG Ling-yun
(Department of Pediatrics,People’s Hospital of Baodi District/Baodi Clinical College,Tianjin Medical University,Tianjin 301800,China)
关键词:
儿童; 传染性单核细胞增多症; EB病毒
Keywords:
Children; Infectious mononucleosis; Epstein-Barr virus
分类号:
R725.1
DOI:
10.3969/j.issn.1006-1959.2020.02.034
文献标志码:
A
摘要:
目的 探讨儿童传染性单核细胞增多症的临床特点及表现。方法 回顾性分析2016年1月~2019年1月我院收治的100例传染性单核细胞增多症患儿的临床资料，总结患儿性别比例、年龄分布、临床表现、合并症、预后转归、EB病毒检测结果。结果儿童传染性单核细胞增多症中男女比例为1.17:1，年龄以 3~6岁为主，发病年龄分布：＜3岁26例，3~6岁62例，＞6岁12例；发病季节分布：春季24例、夏季14例、秋季30例、冬季32例；症状表现主要为发热、咽峡炎和颈部淋巴结肿大，其它有眼险浮肿、皮疹、脾脏肿大、肝脏肿大等，不同年龄患儿的临床表现，除咽峡炎外，所有患儿发热、皮疹、淋巴结大、肝脏肿大、脾脏肿大及眼睑浮肿比例比较，差异均无统计学意义（P＞0.05）；实验室检查主要有白细胞、外周血淋巴细胞升高，外周血有异型淋巴细胞等。血清EB病毒检测结果显示衣壳抗原IgG抗体阳性率90%；EB病毒低亲和力抗体100%，EB病毒DNA 100%。结论 儿童传染性单核细胞增多症秋末至初春多发，年龄以3~6岁多见，无明显性别差异，临床症状表现多样，患儿外周血白细胞及淋巴细胞多高于正常值，血EB病毒抗体及EB病毒DNA检测有助于临床确诊该病。
Abstract:
Objective To explore the clinical characteristics and manifestations of childhood infectious mononucleosis. Methods The clinical data of 100 children with infectious mononucleosis treated in our hospital from January 2016 to January 2019 were retrospectively analyzed, and the sex ratio, age distribution, clinical manifestations, comorbidities, and prognosis of children were summarized EB virus test results.Results The male-to-female ratio of infectious mononucleosis in children is 1.17: 1, and the age is mainly 3 to 6 years. The age distribution of onset is: 26 cases <3 years old, 62 cases 3 to 6 years old, and 12 cases> 6 years old. Distribution: 24 cases in spring, 14 in summer, 30 in autumn, and 32 in winter. Symptoms are mainly fever, angina, and cervical lymphadenopathy. Others include eye oedema, rash, splenomegaly, and liver enlargement. The comparison of clinical manifestations of children at different ages showed that all patients except pharyngitis had fever, rash, enlarged lymph nodes, liver enlargement, spleen enlargement, and eyelid edema,the differences were not statistically significant (P>0.05); Laboratory tests mainly include increased white blood cells, peripheral blood lymphocytes, peripheral blood and atypical lymphocytes. The serum EB virus test results showed that the positive rate of IgG antibody against capsid antigen was 90%; the low affinity antibody of EB virus was 100%, and the EB virus DNA was 100%.Conclusion Children with infectious mononucleosis frequently occur from late autumn to early spring, age is 3~6 years old, there is no significant gender difference, clinical symptoms are diverse, children with peripheral blood white blood cells and lymphocytes are more than normal, blood EB virus antibody and EB virus DNA detection is helpful to clinical diagnosis of the disease.

参考文献/References:

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更新日期/Last Update: 2020-01-15