[1]许 雷.氨茶碱与甲泼尼龙琥珀酸钠联合治疗慢性阻塞性肺病急性加重期的临床效果及对血清CRP水平、PaO2的影响[J].医学信息,2025,38(13):150-153.[doi:10.3969/j.issn.1006-1959.2025.13.030]
　XU Lei.Clinical Effect of Aminophylline Combined with Methylprednisolone Sodium Succinate in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease and its Effect on Serum CRP Level and PaO2[J].Journal of Medical Information,2025,38(13):150-153.[doi:10.3969/j.issn.1006-1959.2025.13.030]
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氨茶碱与甲泼尼龙琥珀酸钠联合治疗慢性阻塞性肺病急性加重期的临床效果及对血清CRP水平、PaO2的影响()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年13期
页码:
150-153
栏目:
论著
出版日期:
2025-07-01

文章信息/Info

Title:
Clinical Effect of Aminophylline Combined with Methylprednisolone Sodium Succinate in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease and its Effect on Serum CRP Level and PaO2
文章编号:
1006-1959（2025）13-0150-04
作者:
许 雷
玉山县黄家驷医院/玉山县人民医院呼吸与危重症医学科，江西 玉山 334700
Author(s):
XU Lei
Department of Respiratory and Critical Care Medicine, Yushan County Huangjiasi Hospital/Yushan People’s Hospital, Yushan 334700, Jiangxi, China
关键词:
氨茶碱; 甲泼尼龙琥珀酸钠; 慢性阻塞性肺病急性加重期; CRP; PaO2
Keywords:
Aminophylline;  Methylprednisolone sodium succinate;  Acute exacerbation of chronic obstructive pulmonary disease;  CRP;  PaO2
分类号:
R563
DOI:
10.3969/j.issn.1006-1959.2025.13.030
文献标志码:
A
摘要:
目的 探究氨茶碱与甲泼尼龙琥珀酸钠联合治疗慢性阻塞性肺病急性加重期的临床效果及对血清CRP水平、PaO2的影响。方法 选取玉山县黄家驷医院2021年5月-2024年5月收治的慢性阻塞性肺病急性加重期患者60例作为研究对象，按照随机数字表法将其分为对照组和研究组，每组30例。对照组使用氨茶碱治疗，研究组在对照组基础上应用甲泼尼龙琥珀酸钠治疗。比较两组临床效果、肺功能[第1秒用力肺活量（FEV1）、用力肺活量（FCV）、第1秒用力肺活量占用力肺活量比值（FEV1/FCV）]、血清炎症因子水平[肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、降钙素原（PCT）、C反应蛋白（CRP）]、血气指标水平[pH、动脉血二氧化碳分压（PaCO2）、动脉血氧分压（PaO2）]。结果 研究组治疗总有效率高于对照组（P＜0.05）。研究组肺功能指标均优于对照组（P＜0.05）。研究组血清炎症因子水平均低于对照组（P＜0.05）。研究组PaCO2水平低于对照组，PaO2水平高于对照组（P＜0.05）。结论 氨茶碱与甲泼尼龙琥珀酸钠联合治疗慢性阻塞性肺病急性加重期患者的临床效果确切，能够改善患者肺功能，减轻患者炎症反应，改善临床效果及血气指标水平，值得临床应用。
Abstract:
Objective To explore the clinical effect of aminophylline combined with methylprednisolone sodium succinate in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its effect on serum CRP level and PaO2. Methods A total of 60 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to Yushan County Huangjiasi Hospital from May 2021 to May 2024 were selected as the research objects. According to the random number table method, they were divided into control group and study group, with 30 patients in each group. The control group was treated with aminophylline, and the study group was treated with methylprednisolone sodium succinate on the basis of the control group. The clinical effect, lung function [forced vital capacity in the first second (FEV1), forced vital capacity (FCV), ratio of forced vital capacity in the first second to forced vital capacity (FEV1/FCV)], serum inflammatory factor levels [tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), procalcitonin (PCT), C-reactive protein (CRP)], blood gas index levels [pH, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of oxygen (PaO2)] were compared between the two groups. Results The total effective rate of treatment in the study group was higher than that in the control group (P<0.05). The lung function indexes of the study group were better than those of the control group (P<0.05). The levels of serum inflammatory factors in the study group were lower than those in the control group (P<0.05). The level of PaCO2 in the study group was lower than that in the control group, while the level of PaO2 was higher than that in the control group (P<0.05). Conclusion The combination of aminophylline and methylprednisolone sodium succinate has a definite clinical effect in the treatment of patients with acute exacerbation of chronic obstructive pulmonary disease, which can improve the lung function of patients, reduce the inflammatory response of patients, improve the clinical effect and blood gas index level, and is worthy of clinical application.

参考文献/References:

[1]王梅.多索茶碱与氨茶碱在慢阻肺治疗中的疗效比较探究[J].中国农村卫生,2019,11(14):78-80.[2]韩冲锋.氨茶碱治疗慢阻肺稳定期患者的疗效及对患者生活质量的影响[J].贵州医药,2019,43(6):924-926.[3]李作卿,苏醒,王毓兴.氨茶碱联合糖皮质激素治疗慢性阻塞性肺疾病急性加重期合并呼吸衰竭临床研究[J].中国药业,2023,32(17):86-89.[4]李竺宜,彭俊杰,杨从意,等.氨茶碱联合百令胶囊对稳定期慢性阻塞性肺疾病气道功能及相关指标的影响[J].西北药学杂志,2023,38(5):181-186.[5]郑宇静,李婷,郭思瑞,等.多索茶碱与茶碱/氨茶碱治疗支气管哮喘和慢性阻塞性肺疾病的快速卫生技术评估[J].中国药业,2023,32(12):112-115.[6]蒋忠洋,孙欢,张丹,等.小剂量氨茶碱联合适应性压力支持治疗对慢性阻塞性肺疾病急性加重期并发重症呼吸衰竭患者胸肺顺应性及脑氧代谢的影响[J].中国医院用药评价与分析,2022,22(5):572-575,579.[7]王淑莹,程飞,蔡超,等.N-乙酰半胱氨酸联合氨茶碱治疗慢性肺源性心脏病患者的临床疗效及对血清BNP、CRP水平的影响[J].临床和实验医学杂志,2023,22(21):2258-2262.[8]陆小华,张学会,沈静妍,等.氨茶碱与多索茶碱对老年慢性阻塞性肺疾病患者气道重塑及血清激活素A、转化生长因子β1水平影响的对比研究[J].实用心脑肺血管病杂志,2018,26(7):70-73.[9]林敬明,陈文丽,郑辉才,等.对比布地奈德福莫特罗与氨茶碱治疗缓解期COPD的疗效及对患者血气指标、肺功能影响[J].中国急救复苏与灾害医学杂志,2019,14(7):636-639.[10]陈玲,胡荆江,覃军.低剂量甲泼尼龙琥珀酸钠对重症支原体肺炎患儿T淋巴细胞亚群及炎症因子水平的影响[J].中国现代医学杂志,2023,33(5):63-67.[11]汪珊,韦红,李启先.甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的疗效及对炎症因子的影响[J].蚌埠医学院学报,2022,47(1):44-46.[12]李艳.支原体肺炎患儿经匹多莫德、甲泼尼龙琥珀酸钠联合阿奇霉素治疗对其免疫功能及临床疗效的影响研究[J].贵州医药,2022,46(6):918-919.[13]刘晓萌,张燕北,于海明,等.甲泼尼龙琥珀酸钠治疗儿童重症支原体肺炎的效果及对炎症因子的影响[J].中国医药导报,2021,18(29):98-101.[14]蔚变霞.甲泼尼龙琥珀酸钠联合阿奇霉素治疗小儿重症支原体肺炎疗效及其对免疫功能的影响[J].中国基层医药,2020,27(3):331-334.[15]任治坤,孙艳,殷秀礼,等.静脉短疗程应用甲泼尼龙琥珀酸钠治疗慢性阻塞性肺疾病急性加重期高龄患者疗效及不良反应[J].临床军医杂志,2019,47(9):980-981.[16]付志彬,王珍珍.环孢素联合甲泼尼龙琥珀酸钠冲击对百草枯所致肺纤维化患者血清纤维化指标及尿β2-MGmALB的影响[J].河北医学,2018,24(9):1433-1436.[17]王晋忠.甲泼尼龙琥珀酸钠不同方案对老年慢性阻塞性肺疾病急性加重期患者疗效及安全性比较[J].中国基层医药,2018,25(10):1318-1322.[18]李永涛,常青,陈飞,等.高流量湿化氧疗联合甲泼尼龙琥珀酸钠对慢性阻塞性肺疾病合并呼衰患者疗效的影响[J].中国药物应用与监测,2023,20(5):291-294.[19]郭茂盛.纳洛酮联合注射用甲泼尼龙琥珀酸钠在慢性阻塞性肺疾病急性加重合并Ⅱ型呼吸衰竭中的应用[J].中国药物与临床,2021,21(11):1927-1928.[20]吴一晨.小牛脾提取物联合甲泼尼龙琥珀酸钠对急性呼吸窘迫综合征患者外周血KRT-14及S100A12水平的影响[J].广西医科大学学报,2019,36(2):247-250.

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更新日期/Last Update: 1900-01-01