[1]程秋晨,郑明星,尹 楚,等.中老年人群幽门螺杆菌感染与新型炎症指标的相关性分析[J].医学信息,2025,38(24):65-70.[doi:10.3969/j.issn.1006-1959.2025.24.012]
　CHENG Qiuchen,ZHENG Mingxing,YIN Chu,et al.Correlation Analysis Between Helicobacter Pylori Infection and New Inflammatory Markersin Middle-aged and Elderly People[J].Journal of Medical Information,2025,38(24):65-70.[doi:10.3969/j.issn.1006-1959.2025.24.012]
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中老年人群幽门螺杆菌感染与新型炎症指标的相关性分析()

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
38卷
期数:
2025年24期
页码:
65-70
栏目:
论著
出版日期:
2025-12-15

文章信息/Info

Title:
Correlation Analysis Between Helicobacter Pylori Infection and New Inflammatory Markersin Middle-aged and Elderly People
文章编号:
1006-1959（2025）24-0065-06
作者:
程秋晨; 郑明星; 尹 楚; 汝 燕; 王 龙
安徽医科大学附属宿州医院/宿州市立医院消化内科，安徽 宿州 234000
Author(s):
CHENG Qiuchen;  ZHENG Mingxing;  YIN Chu;  RU Yan;  WANG Long
Department of Gastroenterology, Suzhou Hospital Affiliated to Anhui Medical University/Suzhou Municipal Hospital,Suzhou 234000, Anhui, China
关键词:
体检人群; 幽门螺杆菌; 炎症指标; NLR; SIRI; SII; MLR
Keywords:
Physical examination population;  Helicobacter pylori;  Inflammation indexes;  NLR;  SIRI;  SII;  MLR
分类号:
R573
DOI:
10.3969/j.issn.1006-1959.2025.24.012
文献标志码:
A
摘要:
目的 探究安徽省宿州市中老年体检人群幽门螺杆菌（Hp）感染情况与新型炎症指标之间的相关性。方法 回顾性分析2016年1月4日-2023年12月10日在安徽医科大学附属宿州医院（宿州市立医院）体检中心体检、自愿进行碳呼气试验检测Hp感染情况且年龄≥45岁的成人，共计29 445例。收集其一般资料及血生化指标，比较不同性别、年龄组人群Hp感染率；再将患者分为Hp感染阳性组与阴性组，比较两组一般指标和新型炎症指标水平，将有差异的新型炎症指标纳入多因素Logistic回归分析，探索Hp感染与新型炎症指标的相关性。结果 29 445例研究对象中，总体Hp感染率为35.01%，其中男性Hp感染率为35.82%，高于女性的33.74%；中年人群（45~59岁）Hp感染率为35.89%，高于老年人群（≥60岁）的33.18%，差异均具有统计学意义（P＜0.05）。在总体人群中，与Hp感染阴性组相比，Hp感染阳性组的体重指数、收缩压、舒张压、空腹血糖、甘油三酯、血红蛋白、白细胞、中性粒细胞计数、淋巴细胞计数、单核细胞计数均较高，而新型炎症指标中系统免疫性炎症指数（SII）、中性粒细胞与淋巴细胞计数比值（NLR）及系统性免疫炎症指数（SIRI）较高，血小板与淋巴细胞比值（PLR）及单核细胞与淋巴细胞比值（MLR）较低，差异均有统计学意义（P＜0.05）。将新型炎症指标纳入多因素Logistic回归分析，在调整混杂因素后发现NLR与Hp感染呈正相关，PLR、MLR与Hp感染呈负相关。男性体检人群中，NLR与Hp感染呈正相关，PLR、MLR与Hp感染呈负相关；女性体检人群中，NLR与Hp感染呈正相关，PLR与Hp感染呈负相关。结论 在中老年人群中，Hp感染与新型炎症指标密切相关，其中NLR在中老年人群Hp感染筛查中更值得关注，可作为低成本筛查Hp感染风险的有效辅助工具。
Abstract:
Objective To explore the correlation between Helicobacter pylori (Hp) infection and new inflammatory markers in middle-aged and elderly people undergoing physical examination in Suzhou City, Anhui Province. Methods From January 4, 2016 to December 10, 2023, a total of 29 445 adults aged ≥45 years who underwent physical examination and voluntary carbon breath test to detect Hp infection in the physical examination center of Suzhou Hospital Affiliated to Anhui Medical University (Suzhou Municipal Hospital) were retrospectively analyzed. The general data and blood biochemical indexes were collected, and the Hp infection rates of different genders and age groups were compared. The patients were divided into Hp infection positive group and Hp infection negative group. The levels of general indexes and new inflammatory indexes were compared between the two groups. The different new inflammatory indexes were included in multivariate Logistic regression analysis to explore the correlation between Hp infection and new inflammatory indexes. Results Among the 29 445 subjects, the overall Hp infection rate was 35.01%, and the Hp infection rate of males was 35.82%, which was higher than that of females (33.74%). The Hp infection rate of middle-aged people (45-59 years old) was 35.89%, which was higher than 33.18% of the elderly (≥60 years old), and the difference was statistically significant (P<0.05). In the general population, compared with the Hp infection negative group, the body mass index, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglyceride, hemoglobin, white blood cell, neutrophil count, lymphocyte count and monocyte count of the Hp infection positive group were higher, while the systemic immune inflammation index (SII), neutrophil to lymphocyte count ratio (NLR) and systemic immune inflammation index (SIRI) were higher, platelet to lymphocyte ratio (PLR) and monocyte to lymphocyte ratio (MLR) were lower, and the differences were statistically significant (P<0.05). The new inflammatory markers were included in multivariate logistic regression analysis, after adjusting for confounding factors, it was found that NLR was positively correlated with Hp infection, and PLR and MLR were negatively correlated with Hp infection. In male physical examination population, NLR was positively correlated with Hp infection, while PLR and MLR were negatively correlated with Hp infection. In the female physical examination population, NLR was positively correlated with Hp infection, and PLR was negatively correlated with Hp infection.Conclusion In the middle-aged and elderly population, Hp infection is closely related to new inflammatory markers. Among them, NLR is more worthy of attention in the screening of Hp infection in the middle-aged and elderly population, and can be used as an effective auxiliary tool for low-cost screening of Hp infection risk.

参考文献/References:

[1]Hopkins RJ,Morris JG Jr.Helicobacter pylori: the missing link in perspective[J].Am J Med,1994,97(3):265-277.[2]Tran V,Saad T,Tesfaye M,et al.Helicobacter pylori (H. pylori) risk factor analysis and prevalence prediction: a machine learning-based approach[J].BMC Infect Dis,2022,22(1):655.[3]Chen YC,Malfertheiner P,Yu HT,et al.Global Prevalence of Helicobacter pylori Infection and Incidence of Gastric Cancer Between 1980 and 2022[J].Gastroenterology,2024,166(4):605-619.[4]Zhang L,Zhang D,Wei L,et al.H. pylori infection and osteoporosis: a large-scale observational and mendelian randomization study[J].BMC Infect Dis,2024,24(1):305.[5]Malfertheiner P,Camargo MC,El-Omar EM,et al.Helicobacter pylori infection[J].Nat Rev Dis Primers,2023,9(1):19.[6]Liu P,Yang Y,Yang Y,et al.Different impact on health outcomes of long-term care insurance between urban and rural older residents in China[J].Sci Rep,2023,13(1):253.[7]周志华,王倩,杨楠,等.健康体检人员幽门螺杆菌感染状况及与高脂血症的关系研究[J].国际检验医学杂志,2025,46(16):2015-2020.[8]Lee BE,Park SJ,Kim GH,et al.Anti-inflammatory effects of eupatilin on Helicobacter pylori CagA-induced gastric inflammation[J].PLoS One,2024,19(11):e0313251.[9]Munoz IE,Jijon EH,Porter CK,et al.Helicobacter pylori and its association with autoimmune diseases: systemic lupus erythematosus,rheumatoid arthritis and Sj?gren syndrome[J].J Transl Autoimmun,2021,4:100135.[10]Wang X,Xie Z,Yuan J,et al.Sodium oligomannate disrupts the adherence of Ribhigh bacteria to gut epithelia to block SAA-triggered Th1 inflammation in 5XFAD transgenic mice[J]Cell Discov,2024,10(1):115.[11]Zhao J,Jia Y,Zeng L,et al.Interplay of Systemic Immune-Inflammation Index and Serum Klotho Levels: Unveiling a New Dimension in Rheumatoid Arthritis Pathology[J].Int J Med Sci,2024,21(2):396-403.[12]Hayashi T,Fujita K,Tanigawa G,et al.Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer[J].Oncotarget,2017,8(21):35255-35261.[13]Guo W,Song Y,Sun Y,et al.Systemic immune-inflammation index is associated with diabetic kidney disease in Type 2 diabetes mellitus patients: Evidence from NHANES 2011-2018[J].Front Endocrinol (Lausanne),2022,13:1071465.[14]Melit LE,M?觍rginean MO,Mocan S,et al.The usefulness of inflammatory biomarkers in diagnosing child and adolescent’s gastritis: STROBE compliant article[J].Medicine (Baltimore),2019,98(26):e16188.[15]Lin S,Fu X,Chen G,et al.Prognostic significance of inflammatory indices in hepatocellular carcinoma treated with transarterial chemoembolization: A systematic review and meta-analysis[J].PLoS One,2020,15(3):e0230879.[16]崔静,闵汉琛,汤善宏,等.我国人群幽门螺杆菌感染现状调查：一项多中心横断面研究[J].北京医学,2025,47(6):501-507.[17]Xiong YJ,Du LL,Diao YL,et al.Association of dietary inflammatory index with helicobacter pylori infection and mortality among US population[J].J Transl Med,2023,21(1):538.[18]Baryshnikova NV,Ilina AS,Ermolenko EI,et al.Probiotics and autoprobiotics for treatment of Helicobacter pylori infection[J].World J Clin Cases,2023,11(20):4740-4751.[19]Qiao Y,Zhou Y,Zhao L,et al.Sex differences in Helicobacter pylori infection and recurrence rate among 81,754 Chinese adults: a cross-sectional study[J].BMC Gastroenterol,2024,24(1):305.[20]Liu JF,Guo D,Kang EM,et al.Acute and chronic infection of H. pylori caused the difference in apoptosis of gastric epithelial cells[J].Microb Pathog,2021,150:104717.[21]Han YM,Lee J,Choi JM,et al.The association between Helicobacter pylori with nonalcoholic fatty liver disease assessed by controlled attenuation parameter and other metabolic factors[J].PLoS One,2021,16(12):e0260994.[22]Ohnishi M,Fukui M,Ishikawa T,et al.Helicobacter pylori infection and arterial stiffness in patients with type 2 diabetes mellitus[J].Metabolism,2008,57(12):1760-1764.[23]Lecube A,Valladares S,López-Cano C,et al.The Role of Morbid Obesity in the Promotion of Metabolic Disruptions and Non-Alcoholic Steatohepatitis by Helicobacter Pylori[J].PLoS One,2016,11(11):e0166741.[24]杨淑侠,蔡素丽,杨宁,等.幽门螺杆菌感染对代谢综合征患者血糖血脂代谢的影响[J].中华医院感染学杂志,2021,31(20):3087-3091.[25]Xie Q,He Y,Zhou D,et al.Recent research progress on the correlation between metabolic syndrome and Helicobacter pylori infection[J].PeerJ,2023,11:e15755.[26]Liu M,Hu Z,Wang C,et al.The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori[J].J Mol Med (Berl),2023,101(7):767-781.[27]Rueda-Robles A,Rubio-Tomás T,Plaza-Diaz J,et al.Impact of Dietary Patterns on H. pylori Infection and the Modulation of Microbiota to Counteract Its Effect. A Narrative Review[J].Pathogens,2021,10(7):875.[28]Liu H,Qin Y,Yang J,et al.Helicobacter pylori Infection as a Risk Factor for Abnormal Serum Protein Levels in General Population of China[J].J Inflamm Res,2022,15:2009-2017.[29]韦伟市,吴嘉,于晓阳,等.血常规比值参数对急性缺血性脑卒中患者的临床价值[J].医学研究生学报,2021,34(6):596-600.[30]Dogan Z,Kekilli M.Can neutrophil to lymphocyte ratio be a non-invasive indicator of the presence of duodenal ulcer related Helicobacter pylori in dyspeptic patients?[J].Pract Lab Med,2023,36:e00319.[31]Ock CY,Nam AR,Lee J,et al.Prognostic implication of antitumor immunity measured by the neutrophil-lymphocyte ratio and serum cytokines and angiogenic factors in gastric cancer[J].Gastric Cancer,2017,20(2):254-262.[32]Pointer DJ,Roife D,Powers BD,et al.Neutrophil to lymphocyte ratio,not platelet to lymphocyte or lymphocyte to monocyte ratio,is predictive of patient survival after resection of early-stage pancreatic ductal adenocarcinoma[J].BMC Cancer,2020,20(1):750.

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更新日期/Last Update: 1900-01-01