[1]马荣花,王莉云,沈源春,等.胚胎移植前宫腔内灌注hCG对FET反复着床失败患者 妊娠结局的影响[J].医学信息,2018,31(13):81-83,87.[doi:10.3969/j.issn.1006-1959.2018.13.023]
　MA Rong-hua,WANG Li-yun,SHEN Yuan-chun,et al.Effect of Intrauterine Perfusion of hCG before Embryo Transfer on Pregnancy Outcome in Patients with FET Repeated Implantation Failure[J].Journal of Medical Information,2018,31(13):81-83,87.[doi:10.3969/j.issn.1006-1959.2018.13.023]
点击复制

胚胎移植前宫腔内灌注hCG对FET反复着床失败患者 妊娠结局的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年13期
页码:
81-83,87
栏目:
论著
出版日期:
2018-07-01

文章信息/Info

Title:
Effect of Intrauterine Perfusion of hCG before Embryo Transfer on Pregnancy Outcome in Patients with FET Repeated Implantation Failure
文章编号:
1006-1959（2018）13-0081-04
作者:
马荣花; 王莉云; 沈源春; 韩国华; 鲍玉敏
青海省人民医院生殖医学中心，青海 西宁 810000
Author(s):
MA Rong-hua; WANG Li-yun; SHEN Yuan-chun; HAN Guo-hua; BAO Yu-min
Reproductive Medicine Center,Qinghai People's Hospital,Xining 810000,Qinghai,China
关键词:
宫腔灌注; 人绒毛膜促性腺激素; 胚胎移植; 妊娠结局
Keywords:
Key words：Intrauterine perfusion; Human chorionic gonadotropin; Embryo transfer; Pregnancy outcome
分类号:
R715
DOI:
10.3969/j.issn.1006-1959.2018.13.023
文献标志码:
A
摘要:
目的 探讨宫腔灌注hCG是否通过改善子宫内膜容受性来影响FET患者的妊娠结局。方法 回顾性分析2016年4月~2018年4月就诊于青海省人民医院生殖医学中心的FET患者共365例，分为研究组和对照组，研究组127例于移植前1 d行宫腔内灌注hCG 500 U，研究组138例未行宫腔灌注，比较两组患者的胚胎种植率、临床妊娠率及早期流产率。结果 研究组胚胎种植率34.25%、临床妊娠率52.76%，高于对照组的24.28%， 40.58%，差异有统计学意义（P＜0.05），两组早期流产率对比，差异无统计学意义（P＞0.05）。结论 移植前宫腔内灌注hCG，可提高反复着床失败FET患者的胚胎着床率和临床妊娠率，在一定程度上改善了子宫内膜容受性，该技术对难治性不孕患者带来希望。
Abstract:
Abstract：Objective To investigate whether intrauterine perfusion of hCG affects the pregnancy outcome of FET patients by improving endometrial receptivity.Methods A retrospective analysis of 365 patients with FET from the Reproductive Medicine Center of Qinghai Provincial People's Hospital from April 2016 to April 2018 was divided into study group and control group.In the study group,127 patients underwent intrauterine infusion of hCG 500 U 1 day before transplantation,and 138 patients in the study group did not undergo intrauterine infusion.The embryo implantation rate,clinical pregnancy rate and early abortion rate of the two groups were compared.Results The embryo implantation rate of the study group was 34.25%,the clinical pregnancy rate was 52.76%,which was higher than that of the control group 24.28%,40.58%,the difference was statistically significant(P<0.05).There was no significant difference in the early abortion rate between the two groups(P>0.05).Conclusion The intrauterine perfusion of hCG before transplantation can improve the implantation rate and the clinical pregnancy rate of FET patients with repeated implantation failure, and improve the endometrial receptivity to a certain extent.This technique brings hope to the patients with refractory infertility.

参考文献/References:

[1]Weinerman R,Mainigi M.Why we should transfer frozen instead of fresh embryos:the translational rationale[J].Fertility& Sterility,2014,102(1):10-18. [2]Tsampalas M,Gridelet V,Berndt S,Foidart JM,et al.Human chorionic gon-adotropin:a hormone with immunological and angiogenic properties[J].J Reprod Immunol,2010,85(1):93-98. [3]徐慧颖,李娜,张云山.胚胎植入-子宫内膜容受性是关键[J].生殖医学杂志,2014,23(03):198-202. [4]隋晓倩,于德钦,张冬梅.子宫内膜容受性各相关标志物研究进展[J].生殖与避孕,2015,35(03):185-190. [5]Tsampalas M,Gridelet V,Berndt S,et al.Human choronic gonadotropin:a hormonewith immunological and angiogenic properties[J].J Repord Immunal,2010,85(1):93-98. [6]王会妍,张帅,张云山.胚胎移植前宫腔内灌注hCG在IVF-ET中的应用及hCG提高种植率和妊娠率的有关机制[J].生殖与避孕,2012,32(9):593-598. [7]王慧玲.宫腔灌注HCG对48例不孕症妊娠结局的影响[J].中国民族民间医药,2015,24(05):132. [8]Strug MR,Su R,Young JE,et al.Intrauterine human chorionic gonadotropin infusion in oocyte donors promotes endometrial synchrony and induction of early decidual markers for stromal survival:a randomized clinical trial[J].Human Reproduction,2016,31(7):1552. [9]Barash A,Dekel N,Fieldust S,et al.Local injury to the endometrium doubles the incidence of successful pregnancies in patients undergoing in vitro fertilization[J].Fertil Steril,2003,79(6):1317-1322. [10]张乐,吴亮,于医萍,等.移植前宫腔灌注人绒毛膜促性腺激素对于体外受精-胚胎移植妊娠结局影响的Meta分析[J].中华生殖与避孕杂志,2018,38(02):115-121. [11]Rosen AM,Hermoso MC,Cook-Andersen H,et al.Purification of Human Chorionic Gonadotropin(hCG)for Intrauterine Injection[J].Fertility&Sterility,2013,99(3):S8.

相似文献/References:

[1]黄晓楠,刘玉林.全自动化学发光分析仪检测孕酮和人绒毛膜促性腺激素的性能验证[J].医学信息,2022,35(11):134.[doi:10.3969/j.issn.1006-1959.2022.11.035]
　HUANG Xiao-nan,LIU Yu-lin.Performance verification of Automatic Chemiluminescence Analyzer for Detection of Progesterone and Human Chorionic Gonadotropin[J].Journal of Medical Information,2022,35(13):134.[doi:10.3969/j.issn.1006-1959.2022.11.035]
[2]张羽芳,阳美霞,汤亚茹,等.哺乳动物卵母细胞成熟相关因子研究[J].医学信息,2020,33(14):17.[doi:10.3969/j.issn.1006-1959.2020.14.007]
　ZHANG Yu-fang,YANG Mei-xia,TANG Ya-ru,et al.Study on Factors Related to Maturation of Mammalian Oocytes[J].Journal of Medical Information,2020,33(13):17.[doi:10.3969/j.issn.1006-1959.2020.14.007]
[3]邓智心,袁 莹,邹志玲,等.不孕症患者慢性子宫内膜炎的诊疗[J].医学信息,2021,34(11):31.[doi:10.3969/j.issn.1006-1959.2021.11.010]
　DENG Zhi-xin,YUAN Ying,ZOU Zhi-ling,et al.Diagnosis and Treatment of Chronic Endometritis in Infertility Patients[J].Journal of Medical Information,2021,34(13):31.[doi:10.3969/j.issn.1006-1959.2021.11.010]
[4]刘淑琴.米非司酮联合甲氨蝶呤治疗宫外孕的安全性和有效性分析[J].医学信息,2023,36(08):131.[doi:10.3969/j.issn.1006-1959.2023.08.028]
　LIU Shu-qin.Analysis of the Safety and Efficacy of Mifepristone Combined with Methotrexate in the Treatment of Ectopic Pregnancy[J].Journal of Medical Information,2023,36(13):131.[doi:10.3969/j.issn.1006-1959.2023.08.028]

更新日期/Last Update: 2018-07-01