[1]王允彦.西那卡塞对维持性血液透析继发性甲状旁腺功能亢进患者FGF-23的影响[J].医学信息,2018,31(13):88-90.[doi:10.3969/j.issn.1006-1959.2018.13.025]
　WANG Yun-yan.Effect of Cinacalcet on FGF-23 in Patients with Secondary Hyperparathyroidism during Maintenance Hemodialysis[J].Journal of Medical Information,2018,31(13):88-90.[doi:10.3969/j.issn.1006-1959.2018.13.025]
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西那卡塞对维持性血液透析继发性甲状旁腺功能亢进患者FGF-23的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年13期
页码:
88-90
栏目:
论著
出版日期:
2018-07-01

文章信息/Info

Title:
Effect of Cinacalcet on FGF-23 in Patients with Secondary Hyperparathyroidism during Maintenance Hemodialysis
文章编号:
1006-1959（2018）13-0088-03
作者:
王允彦
天津市第一中心医院肾内科，天津 300192
Author(s):
WANG Yun-yan
Department of Nephrology,Tianjin First Central Hospital,Tianjin 300192,China
关键词:
盐酸西那卡塞片; FGF-23; 继发性甲状旁腺功能亢进; 血液透析
Keywords:
Key words：Cinacalcet hydrochloride tablets; FGF-23; Secondary hyperparathyroidism; Hemodialysis
分类号:
R692.5;R582.1
DOI:
10.3969/j.issn.1006-1959.2018.13.025
文献标志码:
A
摘要:
目的 研究西那卡塞对维持性血液透析继发性甲状旁腺功能亢进患者FGF-23的影响。方法 选取2015年1月~2016年10月在天津市第一中心医院血液净化中心行维持性血液透析治疗合并继发性甲状旁腺功能亢进的患者，按入院顺序随机分为观察组及对照组，对照组40例，给予骨化三醇治疗，观察组39例，给予对照组患者相同的骨化三醇治疗的基础上，再加用盐酸西那卡塞片，两组均连续治疗3个月。监测两组治疗前后的尿素氮、血肌酐、KT/V、血清钙、血清磷、碱性磷酸酶、钙磷乘积、全段甲状旁腺激素 (iPTH)及血清FGF-23。结果 治疗后，两组患者的BUN、SCr和Kt/V 较治疗前,差异无统计学意义（P＞0.05）；血清钙观察组治疗后低于对照组（P＜0.05），对照组治疗前后，差异无统计学意义（P＞0.05）；两组血清磷、ALP、钙磷乘积、iPTH、FGF-23治疗后降低，且治疗后观察组优于对照组，差异有统计学意义 (P<0.05)。结论 西那卡塞对于维持性血液透析合并继发性甲状旁腺功能亢进的患者能够降低甲状旁腺激素及FGF-23水平，缩小甲状旁腺体积。
Abstract:
Abstract：Objective To study the effect of Cinacalcet on FGF-23 in patients with secondary hyperparathyroidism during maintenance hemodialysis.Methods Patients who underwent maintenance hemodialysis treatment with secondary hyperparathyroidism at the Blood Purification Center of Tianjin First Central Hospital from January 2015 to October 2016 were randomly divided into observation group and control group according to the order of admission.In the control group,40 patients were treated with calcitriol, and 39 patients in the observation group were given the same calcitriol treatment as the control group,plus cinacalcet hydrochloride tablets.The two groups were treated continuously for 3 months.Urea nitrogen,serum creatinine,KT/V,serum calcium,serum phosphorus, alkaline phosphatase,calcium phosphate,total parathyroid hormone(iPTH)and serum FGF-23 were monitored before and after treatment.Results After treatment,there was no significant difference in BUN,SCr and Kt/V between the two groups before treatment (P>0.05),and the serum calcium observation group was lower than the control group after treatment(P<0.05),the difference was not statistically significant before and after treatment in the control group(P>0.05);the two groups decreased after the treatment of serum phosphorus,ALP,calcium and phosphorus product,iPTH and FGF-23,and the observation group was better than the control group after treatment,the difference was statistically significant(P<0.05).Conclusion Cinacalcet can reduce parathyroid hormone and FGF-23 levels and reduce the volume of parathyroid glands in patients with maintenance hemodialysis and secondary hyperparathyroidism.

参考文献/References:

[1]张凌.慢性肾脏病钙磷代谢紊乱及骨病的处理[J].中国实用内科杂志,2010,30(2):113-115. [2]高珺,汪秀英,王涛,等.增加透析频率对维持性血液透析患者左心室重构的影响[J].江苏医药,2016,42(5):551-554. [3]Moe SM,Chertow GM,Parfrey PS,et al.Cinacalcet,Fibroblast Growth Factor-23,and Cardiovascular Disease in Hemodialysis:The Evaluation of Cinacalcet HCI Therapy to Lower Cardiovascular Events(EVOLVE)Trial[J].Circulation,2015,132(1):27-39. [4]Sprague SM,Wetmore JB,Gurevich K,et al.Effect of Cinacalcet and Vitamin D Analogs on Fibroblast Growth Factor-23 during the Treatment of Secondary Hyperparathyroidism[J].Clin J Am Soc Nephrol.2015,10(6):1021-1030. [5]韩鹦赢,王彤,张文玉,等.骨化三醇联合西那卡塞治疗血液透析患者继发性甲状旁腺功能亢进的疗效观察[J].现代药物与临床,2015,12(30):1451-1454. [6]Sharon M,Safa A,Glenn M,et al．Cinacalcet and Fractures in Hemodialysis[J]．J Am SocNephrol,2014(26):351－357． [7]李述捷,阮诗玮,丘余良,等.西那卡塞治疗血液透析患者继发性甲状旁腺功能亢进症有效性和安全性的系统评价[J].中国药房,2016,27(21):2937-2940.

相似文献/References:

[1]邹 鑫,刘秀娟,余燕燕.血液透析对MHD患者血清FGF-23水平与 钙磷代谢的影响[J].医学信息,2018,31(09):119.[doi:10.3969/j.issn.1006-1959.2018.09.036]
　ZOU Xin,LIU Xiu-juan,YU Yan-yan.Effect of Hemodialysis on Serum FGF-23 Level and Calcium and Phosphorus Metabolism in MHD Patients[J].Journal of Medical Information,2018,31(13):119.[doi:10.3969/j.issn.1006-1959.2018.09.036]

更新日期/Last Update: 2018-07-01