[1]谢 磊,李 芳,翟亚男.外用重组人碱性成纤维细胞生长因子联合康复新液治疗 糜烂型扁平苔藓的临床应用[J].医学信息,2018,31(18):124-126.[doi:10.3969/j.issn.1006-1959.2018.18.039]
　XIE Lei,LI Fang,ZHAI Ya-nan.Clinical Application of Recombiant Human Basic Fibroblast Growth Factor for External Use Combined with Kangfuxin Solution in the Treatment of Erosive Lichen Planus[J].Journal of Medical Information,2018,31(18):124-126.[doi:10.3969/j.issn.1006-1959.2018.18.039]
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外用重组人碱性成纤维细胞生长因子联合康复新液治疗 糜烂型扁平苔藓的临床应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年18期
页码:
124-126
栏目:
药物与临床
出版日期:
2018-09-15

文章信息/Info

Title:
Clinical Application of Recombiant Human Basic Fibroblast Growth Factor for External Use Combined with Kangfuxin Solution in the Treatment of Erosive Lichen Planus
文章编号:
1006-1959（2018）18-0124-03
作者:
谢 磊1; 李 芳2; 翟亚男1
1.大连大学研究生院，辽宁 大连 116000； 2.大连大学附属中山医院口腔科，辽宁 大连 116000
Author(s):
XIE Lei1; LI Fang2; ZHAI Ya-nan1
1.Graduate School of Dalian University,Dalian 116000,Liaoning,China; 2.Department of Stomatology,Zhongshan Hospital,Dalian University,Dalian 116000,Liaoning,China
关键词:
口腔扁平苔藓; 外用重组人碱性成纤维细胞生长因子; 康复新液
Keywords:
Key words：Oral lichenplanus; Recombiant human basic fibroblast growth factor for external use; Kangfuxin solution
分类号:
R276.8
DOI:
10.3969/j.issn.1006-1959.2018.18.039
文献标志码:
A
摘要:
目的 探讨外用重组人碱性成纤维细胞生长因子与康复新液联合应用对于糜烂型扁平苔藓的疗效。方法 选取我院收治的90例糜烂型扁平苔藓患者作为研究对象，随机分为实验组和对照组，各45例。实验组采用重组人碱性成纤维细胞生长因子与康复新液联合治疗，对照组采用康复新液含漱。观察治疗前后患者客观指标体征和主观症状评分情况，比较两组临床疗效。结果 治疗4周后实验组客观指标记分为（0.81±0.35）分、主观症状评分为（0.31±0.27）分，低于对照组的（1.38±0.41）分、（0.76±0.39）分，差异有统计学意义（P＜0.05）；实验组治疗总有效率为82.22%，高于对照组的64.44%，差异有统计学意义（P=0.035）。结论 外用重组人碱性成纤维细胞生长因子联合康复新液联合治疗糜烂型扁平苔藓，治疗效果显著，可有效改善患者临床症状。
Abstract:
Abstract：Objective To investigate the therapeutic effect of recombiant human basic fibroblast growth factor for external use combined with Kangfuxin solution in the treatment of erosive lichen planus.Methods 90 patients with erosive lichen planus admitted to our hospital were selected as subjects and randomly divided into experimental group and control group,45 cases each.The experimental group was treated with recombiant human basic fibroblast growth factor for external use and Kangfuxin solution,while the control group was gargled with Kangfuxin solution.Objective indicators and subjective symptom scores before and after treatment were observed,and the clinical effects of the two groups were compared.Results After 4 weeks of treatment,the objective index of the experimental group was (0.81±0.35)points and the subjective symptom score was(0.31±0.27)points,which was lower than the control group(1.38±0.41) points and(0.76±0.39) points,the difference was statistically significant(P<0.05).The total effective rate of the experimental group was 82.22%,which was higher than that of the control group 64.44%,the difference was statistically significant(P=0.035).Conclusion The combination of recombiant human basic fibroblast growth factor for external use and Kangfuxin solution in the treatment of erosive lichen planus has obvious therapeutic effect and can effectively improve the clinical symptoms of patients.

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更新日期/Last Update: 2018-09-15