[1]邹志玲,邓智心,陈 博,等.冻融胚胎移植不同内膜准备方案对不明原因反复种植失败患者妊娠结局的影响[J].医学信息,2018,31(21):94-96.[doi:10.3969/j.issn.1006-1959.2018.21.025]
　ZOU Zhi-Ling,DENG Zhi-xin,CHEN Bo,et al.Pregnancy Outcome in Patients with Unexplained Recurrent Implantation Failure of Frozen Thawed Embryo Transfer in Different Endometrial Preparation[J].Journal of Medical Information,2018,31(21):94-96.[doi:10.3969/j.issn.1006-1959.2018.21.025]
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冻融胚胎移植不同内膜准备方案对不明原因反复种植失败患者妊娠结局的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
31卷
期数:
2018年21期
页码:
94-96
栏目:
临床研究
出版日期:
2018-11-01

文章信息/Info

Title:
Pregnancy Outcome in Patients with Unexplained Recurrent Implantation Failure of Frozen Thawed Embryo Transfer in Different Endometrial Preparation
文章编号:
1006-1959（2018）21-0094-03
作者:
邹志玲1; 邓智心1; 陈 博2; 陈雪梅2
1.广东医科大学研究生学院，广东 湛江 524023；2.广东省东莞市第三人民医院生殖中心，广东 东莞 523326
Author(s):
ZOU Zhi-Ling1; DENG Zhi-xin1; CHEN Bo2; CHEN Xue-mei2
1.Graduate School of Guangdong Medical University,Zhanjiang 254023,Guangdong,China;2.Reproductive Center of the Third People's Hospital of Dongguan City,Dongguan 523326,Guangdong,China
关键词:
冻融胚胎移植; 反复种植失败; 内膜准备; 子宫内膜容受性
Keywords:
Frozen-thawed embryo transfer; Recurrent implantation failure; Endometrial preparation;  Endometrial receptivity
分类号:
R714
DOI:
10.3969/j.issn.1006-1959.2018.21.025
文献标志码:
A
摘要:
目的 探讨不同冻融胚胎移植内膜准备方案对不明原因反复种植失败患者子宫内膜容受性及妊娠结局的影响。方法 回顾分析2016年7月~2018年7月在东莞市第三人民医院生殖中心不明原因反复种植失败≥2次，行冻融胚胎移植的30例患者的临床资料。本周期自身配对比较，按子宫内膜准备方案分组：其中30周期设为HRT组，25周期设为NC组，38周期设为GnRHa-HRT组。结果 NC组与HRT组、GnRHa-HRT组子宫内膜厚度比较，差异有统计学意义（P＜0.05）。GnRHa-HRT组临床妊娠率、胚胎种植率、继续妊娠率明显高于HRT组、NC组，差异有统计学意义（P＜0.05）。结论 NC组比HRT组在冻融周期临床妊娠率有提高的趋势，GnRHa-HRT方案可以显著提高冻融周期胚胎反复种植失败患者的临床妊娠率。
Abstract:
Objective To investigate the effect of Pregnancy outcome in patients with unexplained recurrent implantation failure of frozen thawed embryo transfer in different endometrial preparation. Methods Retrospective analysis of the failure of repeated planting of ≥2 times in the reproductive center of the Third People's Hospital of Dongguan from July 2016 to July 2018,clinical data of 30 cases of frozen and thawed embryo transfer. According to the endometrial preparation scheme, 30 cycles were divided into HRT group, 25 cycles as NC group and 38 cycles as GnRHa-HRT group.Results The difference in endometrial thickness between the NC group and the HRT group and the GnRHa-HRT group was statistically significant (P<0.05).The clinical pregnancy rate, embryo implantation rate and continued pregnancy rate in GnRHa-HRT group were significantly higher than those in HRT group and NC group (P<0.05). Conclusion The clinical pregnancy rate of the NC group is higher than that of the HRT group during the freeze-thaw cycle. The GnRHa-HRT program can significantly improve the clinical pregnancy rate of patients with failed embryo implantation in the freeze-thaw cycle.

参考文献/References:

[1]Younis A,Hawkins K,Mahini H,et al.Serum tumor necrosis factor-alpha,interleukin-6,monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis,PCOS,or unexplained infertility[J].J Assist Reprod Genet,2014,31(11):1445 -1451. [2]吴晓燕,李志凌,林虹.多次胚胎移植失败患者采用冻融胚胎移植3种内膜准备方案结局分析[J].中国计划生育学杂志,2014,22(4):248-251. [3]Arefi S,Hoseini A,Farifteh F,et al.Modified natural cycle frozen-thawed embryo transfer in patients with repeated implantation failure: An observational study[J].Int J Reprod BioMed,2016,14(7):465-470. [4]Chai J,Lee KF,Ng EH,et al.Ovarian stimulation modulates steroid receptor expression and spheroid attachment in peri-implantation endometria: studies on natural and stimulated cycles[J].Fertil Steril,2011,96(3):764-768. [5]Groenewoud ER,Cantineau,Kollen BJ,et al.What is the optimal means of preparing the endometrium in frozenthawed embryo transfer cyclesA systematic review and Meta-analysis[J].Hum Reprod Update,2013,19(5):458-470. [6]东亚君,李玉艳,李敏,等.GnRH-a预处理在冻融胚胎移植中的价值[J].第三军医大学学报,2014,36 (15):1619-1622. [7]Ren J,Sha A,Han D,et al.Does prolonged pituitary down-regulation with gonadotropin-releasing hormone agonist improve the live-birth rate in in vitro fertilization treatment?[J].Fertil Steril,2014,102(1):75-81. [8]Niu ZH,Chen Q,Sun YJ,et al.Long-term pituitary downregulation before frozen embryo transfer could improve pregnancy outcomes in women with adenomyosis[J].Gynecol Endocrinol,2013,29 (12):1026-1030. [9]Kdous M,Chaker A,Bouyahia M,et al.ncreased risk of early pregnancy loss and lower live birth rate with GnRH antagonist vs. long GnRH agonist protocol in PCOS women undergoing controlled ovarian hyperstimulation[J].Tunis Med,2009,87(12):834-842. [10]Ozgur K,Berkkanoglu M,Bulut H,et al.Agonist depot versus OCP programming of frozen embryo transfer: a retrospective analysis of freeze-all cycles[J].Assist Reprod Genet,2016,33 (2):207-214．

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更新日期/Last Update: 2018-11-20