[1]屈佳琪,李 洋.核酸传感器与CD72在系统性红斑狼疮中的作用[J].医学信息,2019,32(14):49-52.[doi:10.3969/j.issn.1006-1959.2019.14.017]
 QU Jia-qi,LI Yang.The Role of Nucleic Acid Sensors and CD72 in Systemic Lupus Erythematosus[J].Journal of Medical Information,2019,32(14):49-52.[doi:10.3969/j.issn.1006-1959.2019.14.017]
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核酸传感器与CD72在系统性红斑狼疮中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年14期
页码:
49-52
栏目:
综述
出版日期:
2019-07-15

文章信息/Info

Title:
The Role of Nucleic Acid Sensors and CD72 in Systemic Lupus Erythematosus
文章编号:
1006-1959(2019)14-0049-04
作者:
屈佳琪李 洋
哈尔滨医科大学附属第二医院风湿免疫科,黑龙江 哈尔滨 150086
Author(s):
QU Jia-qiLI Yang
Department of Rheumatology and Immunology,the Second Affiliated Hospital of Harbin Medical University, Harbin 150086,Heilongjiang,China
关键词:
系统性红斑狼疮CD72NA传感器自身免疫
Keywords:
Key words:Systemic lupus erythematosusCD72NA sensorAutoimmune
分类号:
R593.241
DOI:
10.3969/j.issn.1006-1959.2019.14.017
文献标志码:
A
摘要:
系统性红斑狼疮(SLE)是一种多发于青年女性的累及多个脏器的自身免疫性炎症性结缔组织疾病,其特征为机体产生针对各种细胞核抗原的自身抗体。核酸(NA)传感器在这一过程中起关键作用,一方面NA传感器可以识别微生物NA,并诱导抗微生物的免疫反应;另一方面也可以识别自身NA使B细胞产生自身抗体,同时使类浆细胞的树突状细胞产生IFN-I。CD72是一种抑制性的B细胞共受体,已有研究显示CD72可以调控SLE的发生发展。本文针对核酸传感器与CD72在系统性红斑狼疮中的作用作一简要综述,旨在为临床治疗提供参考。
Abstract:
Abstract:Systemic lupus erythematosus (SLE) is an autoimmune inflammatory connective tissue disease that affects multiple organs in young women. It is characterized by the body's production of autoantibodies against various nuclear antigens. Nucleic acid (NA) sensors play a key role in this process. On the one hand, NA sensors can recognize microbial NA and induce anti-microbial immune responses; on the other hand, they can also recognize their own NA to make B cells produce autoantibodies while making pulp The dendritic cells of the cells produce IFN-I. CD72 is an inhibitory B cell co-receptor, and studies have shown that CD72 can regulate the development of SLE. This article provides a brief review of the role of nucleic acid sensors and CD72 in systemic lupus erythematosus, in order to provide a reference for clinical treatment.

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更新日期/Last Update: 2019-07-15