[1]董淑欣,吴成吉,滕立志,等.中年无症状性脑梗死事件相关电位P300变化及其与 认知功能的相关性研究[J].医学信息,2019,32(16):105-106.[doi:10.3969/j.issn.1006-1959.2019.16.033]
　DONG Shu-xin,WU Cheng-ji,TENG Li-zhi,et al.Changes of Event-related Potential P300 in Middle-aged Patients with Asymptomatic Cerebral Infarction and Its Correlation with Cognitive Function[J].Journal of Medical Information,2019,32(16):105-106.[doi:10.3969/j.issn.1006-1959.2019.16.033]
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中年无症状性脑梗死事件相关电位P300变化及其与 认知功能的相关性研究()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年16期
页码:
105-106
栏目:
临床研究
出版日期:
2019-08-15

文章信息/Info

Title:
Changes of Event-related Potential P300 in Middle-aged Patients with Asymptomatic Cerebral Infarction and Its Correlation with Cognitive Function
文章编号:
1006-1959（2019）16-0105-02
作者:
董淑欣1; 吴成吉1; 滕立志2; 李丛言1
1.佳木斯大学附属第一医院神经四科，黑龙江 佳木斯 154007； 2.佳木斯大学临床医学院，黑龙江 佳木斯 154007
Author(s):
DONG Shu-xin1; WU Cheng-ji1; TENG Li-zhi2; LI Cong-yan1
1.Fourth Department of Neurology,First Affiliated Hospital of Jiamusi University,Jiamusi 154007,Heilongjiang,China; 2.School of Clinical Medicine,Jiamusi University,Jiamusi 154007,Heilongjiang,China
关键词:
无症状性脑梗死; 相关电位P300; 认知功能
Keywords:
Key words：Middle-aged asymptomatic cerebral infarction; Correlation potential P300; Cognitive function
分类号:
R395.1
DOI:
10.3969/j.issn.1006-1959.2019.16.033
文献标志码:
A
摘要:
目的 探讨中年无症状性脑梗死事件相关电位P300变化及与认知功能的相关性。方法 选择2017年5月~2018年10月我院收治的中年无症状性脑梗死患者71例设为观察组，选择同期治疗的非脑梗死患者65例设为对照组。两组入院后均采用NEUROPACK型肌电图及诱发电位仪完成事件相关电位P300测定，采用HAMD、MMSE检查量表评估认知功能，并分析中年无症状性脑梗死事件电位P300与认知功能相关性。结果 观察组P3L、HAMD评分高于对照组[（384.57±24.71）vs（350.51±24.59）、（23.23±2.31）分vs（14.51±1.95）分]，Amp、MMSE评分低于对照组[（11.67±2.15）vs（16.89±3.49）、（20.12±0.34）分vs（24.69±0.62）分]，差异有统计学意义（P＜0.05）。中年无症状性脑梗死事件电位P300与认知功能相关性分析结果表明：P3L与HAMD评分呈正相关性（r=0.693，P=0.017），MMSE评分呈负相关性（r=-0.392，P=0.033）；事件电位Amp与HAMD评分呈负相关性（r=-0.592，P=0.039），MMSE评分呈正相关性（r=0.593，P=0.044）。结论 中年无症状性脑梗死患者常伴有相关电位P300变化，表现为潜伏期延长及波幅下降，与认知功能存在相关性，能评估患者疾病严重程度。
Abstract:
Abstract：Objective To investigate the changes of event-related potential P300 in middle-aged asymptomatic cerebral infarction and its correlation with cognitive function.Methods 71 middle-aged patients with asymptomatic cerebral infarction treated from May 2017 to October 2018 were selected as observation group, and 65 non-cerebral infarction patients treated at the same time were selected as control group. Event-related potential P300 was measured by NEUROPACK electromyography and evoked potential instrument in both groups after admission. Cognitive function of the two groups was evaluated by HAMD and MMSE scales.Results The P3L and HAMD in the observation group were higher than that in the control group [(384.57±24.71) vs (350.51±24.59),(23.23±2.31) scores vs(14.51±1.95) scores], the Amp and MMSE were lower than that in the control group [(11.67±2.15) vs (16.89±3.49),(20.12±0.34) scores vs (24.69±0.62) scores],the difference was statistically significant(P<0.05). The correlation analysis between event-related potential P300 and cognitive function in middle-aged patients with asymptomatic cerebral infarction showed that the P3L was positively correlated with the HAMD score (r=0.693,P=0.017), the MMSE score was negatively correlated (r=-0.392,P=0.033); the Amp was negatively correlated with the HAMD score (r=-0.592,P=0.039), the MMSE score was positively correlated(r=0.593,P=0.044).Conclusion Middle-aged patients with asymptomatic cerebral infarction are often accompanied by changes of correlation potential P300, which is characterized by prolonged latency and decreased amplitude. It is correlated with cognitive function and can evaluate the severity of the disease.

参考文献/References:

[1]徐晓娅,郭晓聪,黄琳明,等.事件相关电位P300在血管性轻度认知功能障碍中的应用[J].检验医学与临床,2017,14(Z1):83-85. [2]王红梅,李连贺.神经心理量表联合事件相关电位对中、重度阻塞性睡眠呼吸暂停低通气综合征患者轻度认知功能障碍的评价[J].山东大学耳鼻喉眼学报,2018,32(2):56-61. [3]刘永,詹向红,侯俊林,等.事件相关电位检测与认知功能评价的相关性分析[J].中国现代医学杂志,2017,27(17):54-57. [4]陶仅德,李秋雨,漆强,等.磁共振波谱成像、事件相关电位及脑震荡后综合征问卷评分在轻度创伤性脑损伤中的应用价值研究[J].中国全科医学,2017,20(6):731-735. [5]张华,张淑平,王小新.无症状颈动脉狭窄患者认知功能障碍评估及其危险因素研究[J].中国全科医学,2017,20(17):2051-2056.

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更新日期/Last Update: 2019-08-15