[1]陶 林,马 婷.丁苯酞注射液、胶囊序贯疗法辅治急性进展性脑梗死的 疗效及其对神经功能的影响[J].医学信息,2019,32(18):135-137.[doi:10.3969/j.issn.1006-1959.2019.18.045]
　TAO Lin,MA Ting.Efficacy of Butylphthalide Injection and Capsule Sequential Therapy in the Treatment of Acute Progressive Cerebral Infarction and Its Effect on Neurological Function[J].Journal of Medical Information,2019,32(18):135-137.[doi:10.3969/j.issn.1006-1959.2019.18.045]
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丁苯酞注射液、胶囊序贯疗法辅治急性进展性脑梗死的 疗效及其对神经功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年18期
页码:
135-137
栏目:
药物与临床
出版日期:
2019-09-15

文章信息/Info

Title:
Efficacy of Butylphthalide Injection and Capsule Sequential Therapy in the Treatment of Acute Progressive Cerebral Infarction and Its Effect on Neurological Function
文章编号:
1006-1959（2019）18-0135-03
作者:
陶 林; 马 婷
黑龙江省佳木斯市中心医院神经内一科，黑龙江 佳木斯 154002
Author(s):
TAO Lin; MA Ting
Department of Neurology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China
关键词:
急性脑梗死; 丁酚酞注射液; 丁苯酞胶囊; 序贯疗法
Keywords:
Key words：Acute cerebral infarction; Butyl phenolphthalein injection; Butylphthalide capsule;  Sequential therapy
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2019.18.045
文献标志码:
A
摘要:
目的 研究丁苯酞注射液、胶囊序贯疗法辅治急性进展性脑梗死（APCI）的临床疗效。方法 选取2018年2月~2019年3月我院收治的APCI患者76例，随机分为对照组和研究组，每组38例。所有患者均接受神经保护、营养支持等常规治疗，对照组给予依达拉奉治疗，研究组给予依达拉奉联合丁苯酞注射液、胶囊序贯疗法治疗，比较两组Bathel指数与NIHSS评分、炎症指标及血液流变学指标。结果 研究组Bathel指数评分高于对照组[（84.22±6.23）分 vs （77.18±5.83）分]，而NIHSS评分低于对照组[（6.77±1.39）分 vs （13.83±2.45）分]，差异具有统计学意义（P＜0.05）。研究组PTX-3、IL-6、TNF-α水平分别为（3.78±1.97）pg/L、（67.11±41.16）ng/L、（14.27±4.01）ng/L，均低于对照组的（5.55±2.33）pg/L、（183.33±45.48）ng/L、（26.53±4.74）ng/L，差异具有统计学意义（P＜0.05）。研究组PSV、LSV、HSV水平分别为（1.04±0.66）mPa·s、（11.48±2.13）mPa·s、（2.92±0.88）mPa·s，均低于对照组的（2.33±1.03）mPa·s、（12.74±2.35）mPa·s、（4.02±1.31）mPa·s，差异具有统计学意义（P＜0.05）。结论 采用依达拉奉联合丁苯酞注射液、胶囊序贯疗法治疗APCI患者，可增强日常活动能力，改善神经功能与炎症反应，有一定的临床应用价值。
Abstract:
Abstract：Objective To study the clinical efficacy of butylphthalide injection and capsule sequential therapy in the treatment of acute progressive cerebral infarction (APCI). Methods 76 patients with APCI admitted to our hospital from February 2018 to March 2019 were randomly divided into the control group and the study group, with 38 cases in each group. All patients received routine treatment such as neuroprotection and nutritional support. The control group received edaravone treatment. The study group received edaravone combined with butylphthalide injection and capsule sequential therapy. The two groups were compared with Bathel index and NIHSS score, inflammation indicators and blood rheology indicators. Results The Bathel index score of the study group was higher than that of the control group [(84.22±6.23) points vs (77.18±5.83) points], and the NIHSS score was lower than the control group [(6.77±1.39) points vs (13.83±2.45) points], the difference was statistical significance (P<0.05). The levels of PTX-3, IL-6 and TNF-α in the study group were (3.78±1.97) pg/L, (67.11±41.16) ng/L, and (14.27±4.01) ng/L, respectively, which were lower than those of the control group (5.55±2.33) pg/L, (183.33±45.48) ng/L, (26.53±4.74) ng/L, the difference was statistically significant (P<0.05). The PSV, LSV, and HSV levels of the study group were (1.04±0.66) mPa·s, (11.48±2.13) mPa·s, and (2.92±0.88) mPa·s, respectively, which were lower than those of the control group (2.33±1.03) mPa·s, (12.74±2.35) mPa·s, (4.02±1.31) mPa·s, the difference was statistically significant (P<0.05). Conclusion The combination of edaravone combined with butylphthalide injection and capsule sequential therapy for APCI patients can enhance daily activities, improve neurological function and inflammatory response, and has certain clinical application value.

参考文献/References:

[1]李嘉民,张笑娣.丁苯酞注射液对PCI患者的临床疗效评价及对CESs和CD4+CD25+Treg细胞水平的影响[J].贵州医药,2017,41(6):594-596. [2]高居松.丁苯酞注射液及丁苯酞胶囊对急性脑梗死患者的应用价值[J].中西医结合心血管病杂志,2019,7(5):62. [3]焦琳娜,郭艺华,李宝仪,等.丁苯酞氯化钠注射液联合双重抗血小板治疗进展性脑梗死的临床价值分析[J].中国实用医药,2018,13(20):114-115. [4]王喜丰,王文华,张静,等.丁苯酞注射液及丁苯酞胶囊治疗急性脑梗死患者的临床疗效对比[J].实用医学杂志,2016,32(17):2921-2923. [5]平蕾,刘薇薇,刘雷婧.急性脑梗死应用拜阿司匹林联合氯吡格雷与丁苯酞注射液治疗的临床效果评价[J].临床医药文献杂志,2018,5(66):145-146. [6]王莉梅,姚铭,韩铭,等.丁苯酞注射液对急性缺血性脑梗死患者神经功能影响的Meta分析[J].中国新药与临床杂志,2016,35(7):492-496. [7]付海龙.丁苯酞注射液对急性脑梗死患者静脉溶栓后缺血再灌注损伤保护作用的研究[J].中国实用医药,2018,13(30):98-99. [8]吕晓培,卢海丽,史万英,等.阿替普酶静脉溶栓同时联合丁苯酞注射液治疗急性脑梗死的疗效观察[J].河北医药,2017,39(1):69-71. [9]芦云,陈晓虹.早期使用丁苯酞氯化钠注射液对基底节区脑梗死患者侧支循环建立、神经功能的影响分析[J].中国现代药物应用,2018,12(1):88-89. [10]汪敏,沈伟,肖瑶,等.丁苯酞注射液对急性大面积脑梗死体积及基质金属蛋白酶-9的影响[J].中国卒中杂志,2018,13(1):54-57. [11]白艳娟.丁苯酞注射液对脑缺血再灌注损伤大鼠Bcl－2和Bax蛋白表达的影响[J].辽宁医学院学报,2016,37(4):10-12. [12]秦娜,韩丰立.丁苯酞注射液、胶囊序贯疗法辅治APCI疗效及对神经功能、血液流变学和炎症因子水平的影响[J].检验医学与临床,2019,16(2):253-255. [13]吴江平.早期联合应用氯吡格雷与丁苯酞注射液治疗脑梗死临床效果分析[J].中国生化药物杂志,2016,36(1):77-79.

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更新日期/Last Update: 2019-09-15