[1]宋瑞龙,卢 斐,黄艳莉.复方硫酸亚铁叶酸片联合促红细胞生成素治疗肾性贫血的疗效[J].医学信息,2019,32(24):145-147.[doi:10.3969/j.issn.1006-1959.2019.24.052]
　SONG Rui-long,LU Fei,HUANG Yan-li.Efficacy of Compound Ferrous Sulfate Folic Acid Tablets Combined with Erythropoietin in the Treatment of Renal Anemia[J].Medical Information,2019,32(24):145-147.[doi:10.3969/j.issn.1006-1959.2019.24.052]
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复方硫酸亚铁叶酸片联合促红细胞生成素治疗肾性贫血的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
32卷
期数:
2019年24期
页码:
145-147
栏目:
药物与临床
出版日期:
2019-12-15

文章信息/Info

Title:
Efficacy of Compound Ferrous Sulfate Folic Acid Tablets Combined with Erythropoietin in the Treatment of Renal Anemia
文章编号:
1006-1959（2019）24-0145-03
作者:
宋瑞龙; 卢 斐; 黄艳莉
（龙南县第一人民医院肾内科，江西 龙南 341700）
Author(s):
SONG Rui-long; LU Fei; HUANG Yan-li
(Department of Nephrology,Longnan First People’s Hospital,Longnan 341700,Jiangxi,China)
关键词:
慢性肾衰; 非透析; 促红细胞生成素; 肾性贫血
Keywords:
Chronic renal failure; Nondialysis; Erythropoietin; Renal anemia
分类号:
R692.5
DOI:
10.3969/j.issn.1006-1959.2019.24.052
文献标志码:
A
摘要:
目的 探讨复方硫酸亚铁叶酸片联合促红细胞生成素（EPO）治疗肾性贫血的临床效果。方法 选取2017年6月~2019年6月我院收治的50例肾性贫血患者，按照随机数字表法分为对照组和观察组，各25例。对照组给予复方硫酸亚铁叶酸片治疗，观察组在对照组基础上给予EPO治疗，比较两组临床疗效、贫血相关指标水平及不良反应发生率。结果 治疗后，观察组总有效率为84.00%，高于对照组的64.00%，差异有统计学意义（P＜0.05）；两组红细胞比容（Hct）、血红蛋白（Hb）、血清铁蛋白（SF）、血清铁（SI）、总铁结合力（TIBC）、血清转铁蛋白饱和度（TSAT）水平均较治疗前改善，且观察组高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率高于对照组，但差异无统计学意义（P＞0.05）。结论 复方硫酸亚铁叶酸片联合EPO治疗肾性贫血患者，有利于提高治疗效果，改善贫血指标，不良反应轻微，且均在机体耐受范围内。
Abstract:
Objective To investigate the clinical effect of compound ferrous sulfate folic acid tablets combined with erythropoietin (EPO) in the treatment of renal anemia. Methods 50 patients with renal anemia treated in our hospital from June 2017 to June 2019 were selected and divided into control group and observation group according to the random number table method, with 25 cases each.The control group was treated with compound ferrous sulfate folic acid tablets,and the observation group was given EPO treatment on the basis of the control group.The clinical treatment efficacy,levels of anemia-related indicators, and incidence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate in the observation group was 84.00%,which was higher than 64.00% in the control group,the difference was statistically significant(P<0.05).The hematocrit(Hct),hemoglobin(Hb),and serum ferritin (SF),serum iron (SI),total iron binding capacity (TIBC), and serum transferrin saturation (TSAT) levels were improved compared with those before treatment, and the observation group was higher than the control group,the differences were statistically significant(P<0.05);The incidence of adverse reactions in the observation group was higher than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion The combination of ferrous sulfate and folic acid tablets combined with EPO in patients with renal anemia is beneficial to improve the treatment efficacy,improve the anemia index,and have mild adverse reactions,which are all within the tolerance range of the body.

参考文献/References:

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更新日期/Last Update: 2019-12-15