[1]吕 奕,王毓麟.参麦注射液联合阿德福韦酯治疗乙肝肝硬化失代偿期的疗效[J].医学信息,2020,33(06):162-163.[doi:10.3969/j.issn.1006-1959.2020.06.055]
　LYU Yi,WANG Yu-lin.Effect of Shenmai Injection Combined with Adefovir Dipivoxil on Decompensation of Hepatitis B Cirrhosis[J].Medical Information,2020,33(06):162-163.[doi:10.3969/j.issn.1006-1959.2020.06.055]
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参麦注射液联合阿德福韦酯治疗乙肝肝硬化失代偿期的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年06期
页码:
162-163
栏目:
中医中药
出版日期:
2020-03-15

文章信息/Info

Title:
Effect of Shenmai Injection Combined with Adefovir Dipivoxil on Decompensation of Hepatitis B Cirrhosis
文章编号:
1006-1959（2020）06-0162-02
作者:
吕 奕; 王毓麟
（1.天津市西青医院医务科，天津 300380；2.天津市中医药研究院附属医院消化内科，天津 300120）
Author(s):
LYU Yi; WANG Yu-lin
(1.Department of Medical Affairs,Tianjin Xiqing Hospital,Tianjin 300380,China;2.Department of Gastroenterology,the Affiliated Hospital of Tianjin Academy of Chinese Medicine,Tianjin 300120,China)
关键词:
参麦注射液; 阿德福韦酯; 乙肝肝硬化; 失代偿期
Keywords:
Shenmai injection; Adefovir dipivoxil; Hepatitis B liver cirrhosis; Decompensation period
分类号:
R512.6；R575.2
DOI:
10.3969/j.issn.1006-1959.2020.06.055
文献标志码:
A
摘要:
目的 观察临床乙肝肝硬化失代偿期应用参麦注射液联合阿德福韦酯治疗效果。方法 选取2018年4月~2019年4月在天津市中医药研究院附属医院治疗的50例乙肝肝硬化失代偿期患者为研究对象，采用随机数字表法分为对照组和观察组，各25例。对照组给予保肝对症治疗联合阿德福韦酯治疗，观察组在对照组基础上联合参麦注射液治疗，比较两组临床治疗前后肝功能指标[丙氨酸氨基转移酶（ALT）、丙氨酸氨基转移酶（ALT）、总胆红素（TBIL）]、凝血指标[凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、凝血酶时间（TT）]、HBV-DNA转阴率以及并发症发生情况。结果 治疗后两组ALT、ALT、TBIL均低于治疗前，且观察组低于对照组（P＜0.05）；治疗后两组PT、APTT、TT均低于治疗前，且观察组低于对照组（P＜0.05）；治疗后观察组HBV-DNA转阴率为88.00%，高于对照组的72.00%（P＜0.05）。结论 参麦注射液联合阿德福韦酯治疗乙肝肝硬化失代偿期，可有效改善凝血功能，保护肝功能，延迟肝损害，抑制HBV-DNA的复制。
Abstract:
Objective To observe the therapeutic effect of Shenmai injection combined with adefovir dipivoxil in the decompensated stage of clinical hepatitis B cirrhosis.Methods A total of 50 patients with decompensated hepatitis B liver cirrhosis who were treated in the affiliated hospital of Tianjin Academy of Traditional Chinese Medicine from April 2018 to April 2019 were selected as the research subjects. They were divided into control group and observation group by random number table method, each 25 example.The control group received symptomatic liver protection combined with adefovir dipivoxil. The observation group was combined with Shenmai injection on the basis of the control group. The liver function indicators[alanine aminotransferase(ALT), propyl] were compared between the two groups before and after clinical treatment. Amino acid aminotransferase (ALT), total bilirubin (TBIL)], coagulation indicators [prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time(TT)], HBV-DNA negative rate and complications.Results After treatment, the ALT, ALT, and TBIL in the two groups were lower than before treatment, and the observation group was lower than the control group(P<0.05); after treatment, the PT, APTT, and TT were lower in both groups than before treatment, and the observation group was lower than the control group(P<0.05). After treatment, the HBV-DNA negative rate of the observation group was 88.00%, which was higher than 72.00% of the control group(P＜0.05).Conclusion Shenmai injection combined with adefovir dipivoxil in the treatment of decompensation of hepatitis B cirrhosis can effectively improve blood coagulation function, protect liver function, delay liver damage, and inhibit HBV-DNA replication.

参考文献/References:

[1]贺德,彭翔,甄作均,等.参麦注射液预防大鼠化学性肝硬化作用及机制[J].中国现代医学杂志,2005,15(19):2929-2932.[2]吴小微.参麦注射液对肝硬化患者血小板、网织红细胞及红细胞参数的影响[J].海南医学院学报,2014,32(9):1202-1204,1207.[3]中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2015更新版)[J].胃肠病学,2016,21(4):219-240.[4]陈叶青,周国华,刘树旗,等.阿德福韦酯治疗失代偿期乙型肝炎肝硬化临床观察[J].实用药物与临床,2012,15(9):565-566.[5]崔东方.参麦注射液联合拉米夫定治疗失代偿乙肝肝硬化的临床疗效及其对患者肝功能的影响观察[J].北方药学,2017,52(3):46-47.

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更新日期/Last Update: 2020-03-15