[1]王 宁,巴应贵.缺氧诱导因子在肾脏损伤和修复中的作用[J].医学信息,2020,33(14):47-50.[doi:10.3969/j.issn.1006-1959.2020.14.015]
 WANG Ning,BA Ying-gui.The Role of Hypoxia-inducible Factor in Kidney Injury and Repair[J].Medical Information,2020,33(14):47-50.[doi:10.3969/j.issn.1006-1959.2020.14.015]
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缺氧诱导因子在肾脏损伤和修复中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年14期
页码:
47-50
栏目:
综述
出版日期:
2020-07-15

文章信息/Info

Title:
The Role of Hypoxia-inducible Factor in Kidney Injury and Repair
文章编号:
1006-1959(2020)14-0047-04
作者:
王 宁巴应贵
(青海大学,青海 西宁 810000)
Author(s):
WANG NingBA Ying-gui
(Qinghai University,Xining 810000,Qinghai,China)
关键词:
缺氧低氧诱导因子肾损伤肾脏修复
Keywords:
HypoxiaHypoxia-induciblefactorKidneyinjuryKidney repair
分类号:
R692
DOI:
10.3969/j.issn.1006-1959.2020.14.015
文献标志码:
A
摘要:
急性和慢性肾脏疾病都会发生缺氧,即细胞和组织缺氧。缺氧诱导因子(HIF)是缺氧状态下基因表达的“主”转录因子。研究表明,HIF通过调节HIF的靶基因在肾脏损伤和修复中发挥重要作用。然而关于HIF在肾脏损伤和修复中的病理作用还存在争议,基于此,本文主要就HIF在肾脏中的分布及检测、HIF的靶基因及其对肾脏内分泌功能的影响、HIF在急性肾损伤(AKI)中的信号机制及在肾脏修复中的作用作一综述,旨在为阐明HIF在肾脏损伤和修复中的病理作用提供帮助。
Abstract:
Both acute and chronic kidney disease can cause hypoxia,thatis,hypoxia in cells and tissues.Hypoxia-inducible factor(HIF)is the "master" transcription factor for gene expression under hypoxia.Studies have shown that HIF plays an important role in kidney injury and repair by regulating the target genes of HIF.However,there is still controversy about the pathological role of HIF in kidney injury and repair.Based on this,this article mainly focuses on the distribution and detection of HIF in the kidney,the target genes of HIF and their effects on renal endocrine function,and HIF in acute kidney injury(AKI)is a review of the signaling mechanism and its role in kidney repair,aiming to help elucidate the pathological role of HIF in kidney injury and repair.

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更新日期/Last Update: 1900-01-01