[1]陈甜甜,潘跃银,沈夏波.新辅助内分泌治疗与新辅助化疗用于乳腺癌中的短期疗效Meta分析[J].医学信息,2020,33(14):67-71，75.[doi:10.3969/j.issn.1006-1959.2020.14.020]
　CHEN Tian-tian,PAN Yue-yin,SHEN Xia-bo.Meta-analysis of Short-term Efficacy of Neoadjuvant Endocrine Therapy and Neoadjuvant Chemotherapy in Breast Cancer[J].Medical Information,2020,33(14):67-71，75.[doi:10.3969/j.issn.1006-1959.2020.14.020]
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新辅助内分泌治疗与新辅助化疗用于乳腺癌中的短期疗效Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年14期
页码:
67-71，75
栏目:
论著
出版日期:
2020-07-15

文章信息/Info

Title:
Meta-analysis of Short-term Efficacy of Neoadjuvant Endocrine Therapy and Neoadjuvant Chemotherapy in Breast Cancer
文章编号:
1006-1959（2020）14-0067-06
作者:
陈甜甜; 潘跃银; 沈夏波
（1.安徽医科大学第一附属医院肿瘤科，安徽 合肥 230022；2.安徽省立医院肿瘤科，安徽 合肥 230001）
Author(s):
CHEN Tian-tian; PAN Yue-yin; SHEN Xia-bo
(1.Department of Oncology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China;2.Department of Oncology,Anhui Provincial Hospital,Hefei 230001,Anhui,China)
关键词:
乳腺癌; 新辅助内分泌治疗; 新辅助化疗
Keywords:
Breast cancer; Neoadjuvant endocrine therapy; Neoadjuvant chemotherapy
分类号:
R737.9
DOI:
10.3969/j.issn.1006-1959.2020.14.020
文献标志码:
A
摘要:
目的 对新辅助内分泌治疗和新辅助化疗在乳腺癌治疗中的短期疗效进行系统评价，以期为临床诊疗工作中新辅助治疗方式的选择提供参考。方法 通过检索中国知网、万方、维普、中国期刊网全文数据库和Cochrane Library、PubMed、EMBASE、Web of Science等数据库，检索出直接比较新辅助内分泌治疗和新辅助化疗短期疗效的文献，采用RevMan 5.3作为数据分析工具进行Meta分析，比较两种方法的肿瘤缓解率（RR）、临床完全缓解率（cCR）、病理完全缓解率（pCR）和保乳率（BCS）。结果 最后纳入13篇文献，共1380例乳腺癌患者，其中新辅助内分泌组为598例（43.33%），新辅助化疗组为782例（56.67%）。Meta分析结果显示：在ER阳性患者中，两组RR[OR=0.79，95%CI（0.58，1.06），P=0.12]、cCR[OR=0.45，95%CI（0.15，1.39），P=0.16]、pCR[OR=0.56，95%CI（0.28，1.13），P=0.10]、BCS[OR=1.23，95%CI（0.83，1.82），P=0.29]比较，差异无统计学意义（P＞0.05）；在HER-2阴性患者中，两组cCR[OR=0.38，95%CI（0.06，2.33），P=0.30]、pCR[OR=0.56，95%CI（0.24，1.32），P=0.19]比较，差异无统计学意义（P＞0.05）。结论 ER阳性、HER-2阴性的乳腺癌患者行新辅助内分泌治疗可以获得与新辅助化疗相似的疗效，但尚未表现出优势。新辅助内分泌治疗并不能使ER阳性患者得到更多获益。
Abstract:
Objective To systematically evaluate the short-term efficacy of neoadjuvant endocrine therapy and neoadjuvant chemotherapy in breast cancer treatment, with a view to providing a reference for the selection of neoadjuvant treatment methods in clinical diagnosis and treatment.Methods By searching China HowNet, Wanfang, Weipu, China Journal Net full-text database and Cochrane Library, PubMed, EMBASE, Web of Science and other databases, we retrieved the literature that directly compared the short-term efficacy of neoadjuvant endocrine therapy and neoadjuvant chemotherapy, using RevMan 5.3 Meta analysis as a data analysis tool, comparing the tumor remission rate (RR), clinical complete remission rate (cCR), pathological complete remission rate (pCR) and breast-conservation rate (BCS) of the two methods. Results Finally, 13 articles were included, a total of 1380 breast cancer patients, including 598 cases (43.33%) in the neoadjuvant endocrine group and 782 cases (56.67%) in the neoadjuvant chemotherapy group. Meta analysis results showed that: in ER-positive patients, RR [OR=0.79, 95%CI(0.58, 1.06),P=0.12], cCR (OR=0.45,95%CI(0.15,1.39),P=0.16), pCR[OR=0.56, 95%CI(0.28, 1.13), P=0.10], BCS [OR=1.23, 95%CI(0.83, 1.82), P=0.29], the difference was not statistically significant(P＞0.05); In HER-2 negative patients, cCR[OR=0.38, 95%CI(0.06, 2.33), P=0.30], pCR [OR=0.56, 95%CI(0.24, 1.32), P=0.19],the difference was not statistically significant (P＞0.05).Conclusion Neoadjuvant endocrine therapy for breast cancer patients with ER positive and HER-2 negative can obtain similar efficacy as neoadjuvant chemotherapy, but has not shown advantages. Neoadjuvant endocrine therapy does not benefit patients with positive ER.

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更新日期/Last Update: 1900-01-01