[1]张 琴.哺乳期与非哺乳期乳腺炎患者乳腺脓液分离菌的分布及耐药性分析[J].医学信息,2020,33(16):145-148.[doi:10.3969/j.issn.1006-1959.2020.16.046]
　ZHANG Qin.Analysis of the Distribution and Drug Resistance of Isolates from Breast Pus in Lactating and Non-lactating Mastitis Patients[J].Medical Information,2020,33(16):145-148.[doi:10.3969/j.issn.1006-1959.2020.16.046]
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哺乳期与非哺乳期乳腺炎患者乳腺脓液分离菌的分布及耐药性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年16期
页码:
145-148
栏目:
调查分析
出版日期:
2020-08-15

文章信息/Info

Title:
Analysis of the Distribution and Drug Resistance of Isolates from Breast Pus in Lactating and Non-lactating Mastitis Patients
文章编号:
1006-1959（2020）16-0145-04
作者:
张 琴
（成都市妇女儿童中心医院检验科，四川 成都 610091）
Author(s):
ZHANG Qin
(Department of Laboratory Medicine,Chengdu Women and Children’s Central Hospital,Chengdu 610091,Sichuan,China)
关键词:
乳腺炎; 菌群分布; 耐药性; 哺乳期; 非哺乳期
Keywords:
Mastitis; Flora distribution; Drug resistance; Lactating period; Non-lactating peri
分类号:
R378
DOI:
10.3969/j.issn.1006-1959.2020.16.046
文献标志码:
A
摘要:
目的 了解哺乳期及非哺乳期乳腺炎患者乳腺脓液的分离菌分布特征及耐药性，为临床合理用药提供实验室依据。方法 收集2017年1月~2018年12月我院哺乳期及非哺乳期乳腺炎患者（包括门诊及住院患者）送检脓液标本2524例，分离细菌采用VITEK 2 Compact 全自动微生物鉴定系统进行菌种鉴定及药敏试验，分析哺乳期组及非哺乳期组检出细菌的分布及药物敏感性。结果 所有标本分离出726株细菌，哺乳期乳腺炎患者分离出586株细菌，其中金黄色葡萄球菌495株（84.47%）居第一位，其次为表皮葡萄球菌52株（8.87%）；非哺乳期乳腺炎患者分离出140株细菌，其中金黄色葡萄球菌59株（42.14%）居第一位，其次是kroppenstedtii.棒状杆菌53株（37.86%）。哺乳期患者金黄色葡萄球菌检出比例高于非哺乳期患者（P＜0.05）；非哺乳期患者kroppenstedtii.棒状杆菌检出比例高于哺乳期患者（P＜0.05）；哺乳期乳腺炎患者乳腺脓液耐甲氧西林金黄色葡萄球菌（Methicillin-resistant staphylococcus aureus，MRSA）检出率（45.25%）高于非哺乳期乳腺炎患者（30.51%）（P＜0.05）；哺乳期及非哺乳期乳腺炎患者检出金黄色葡萄球菌未发现对万古霉素、利福平、利奈唑胺、替加环素、奎奴普丁/达福普耐药的菌株；对喹诺酮类药物及庆大霉素、复方新诺明耐药率＜15.50%；对青霉素耐药率＞82.93%。哺乳期及非哺乳期检出的MRSA对所检测的抗菌药物耐药率比较，差异无统计学意义（P＞0.05）。哺乳期检出的MSSA对复方新诺明的耐药率（15.50%）高于非哺乳期检出的MSSA（2.44%）（P＜0.05）。结论 我院哺乳期及非哺乳期乳腺炎患者脓汁分离菌以金黄色葡萄球菌为主。kroppenstedtii.棒状杆菌主要分离自非哺乳期乳腺炎患者，哺乳期乳腺炎患者极少检出。对金黄色葡萄球菌感染首选万古霉素、利奈唑烷、替加环素、庆大霉素、利福平及奎奴普丁/达福普汀。
Abstract:
Objective To understand the distribution characteristics and drug resistance of isolates from breast pus in breast-feeding and non-lactating patients with mastitis, and to provide laboratory evidence for clinical rational drug use.Methods From January 2017 to December 2018, 2524 pus specimens from lactating and non-lactating mastitis patients (including outpatients and inpatients) were collected for examination in our hospital. The bacteria were isolated using the VITEK 2 Compact automatic microbial identification system. Species identification and drug susceptibility test, analysis of the distribution and drug sensitivity of bacteria detected in the lactating group and non-lactating group.Results 726 strains of bacteria were isolated from all specimens, 586 strains were isolated from patients with lactating mastitis, of which 495 strains of Staphylococcus aureus (84.47%) ranked first, followed by 52 strains of Staphylococcus epidermidis (8.87%); non-lactating period 140 strains of bacteria were isolated from patients with mastitis, of which 59 strains of Staphylococcus aureus (42.14%) ranked first, followed by 53 strains of Corynebacterium kroppenstedtii (37.86%). The proportion of Staphylococcus aureus detected in lactating patients was higher than that in non-lactating patients (P<0.05); The proportion of Corynebacterium kroppenstedtii. detected in non-lactating patients was higher than that in lactating patients (P<0.05); breast pus in lactating mastitis patients was detected with(Methicillin-resistant staphylococcus aureus MRSA)the rate (45.25%) was higher than that of patients with non-lactating mastitis (30.51%) (P<0.05); Staphylococcus aureus was detected in patients with lactating and non-lactating mastitis, but no effect on vancomycin, rifampicin and linen was found. Strains resistant to azolamide, tigecycline, quinupristin/dafopril; resistance to quinolones, gentamicin, and compound trimethoprim: <15.50%; resistance to penicillin> 82.93% . There was no statistically significant difference in the resistance rate of MRSA detected during lactation and non-lactation to the detected antimicrobial drugs (P>0.05). The resistance rate (15.50%) of MSSA detected during lactation to compound trimethoprim was higher than MSSA detected during non-lactation period (2.44%) (P<0.05).Conclusion Staphylococcus aureus is the main bacteria isolates from the pus of breast-feeding and non-lactating mastitis patients in our hospital Corynebacterium kroppenstedtii. is mainly isolated from patients with non-lactating mastitis, and it is rarely detected in patients with lactating mastitis. Vancomycin, linezolid, tigecycline, gentamicin, rifampin and quinupristin/dalfopristin are the first choices for Staphylococcus aureus infection.

参考文献/References:

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更新日期/Last Update: 1900-01-01