[1]刘小娟.大剂量奥美拉唑治疗消化性溃疡出血的有效性与安全性[J].医学信息,2020,33(17):143-145.[doi:10.3969/j.issn.1006-1959.2020.17.041]
　LIU Xiao-juan.Efficacy and Safety of High-dose Omeprazole in the Treatment of Peptic Ulcer Bleeding[J].Medical Information,2020,33(17):143-145.[doi:10.3969/j.issn.1006-1959.2020.17.041]
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大剂量奥美拉唑治疗消化性溃疡出血的有效性与安全性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年17期
页码:
143-145
栏目:
药物与临床
出版日期:
2020-09-01

文章信息/Info

Title:
Efficacy and Safety of High-dose Omeprazole in the Treatment of Peptic Ulcer Bleeding
文章编号:
1006-1959（2020）17-0143-03
作者:
刘小娟
（成都市第二人民医院消化科，四川 成都 610017）
Author(s):
LIU Xiao-juan
(Department of Gastroenterology,Chengdu Second People’s Hospital,Chengdu 610017,Sichuan,China)
关键词:
无痛内镜; 大剂量; 奥美拉唑; 消化性溃疡出血; 安全性
Keywords:
Painless endoscopy; High-dose; Omeprazole; Peptic ulcer bleeding; Safety
分类号:
R573.1
DOI:
10.3969/j.issn.1006-1959.2020.17.041
文献标志码:
A
摘要:
目的 研究无痛内镜下止血联合大剂量奥美拉唑治疗消化性溃疡的临床疗效和安全性。方法 选取2019年1月~2020年1月在我院诊治的86例消化性溃疡出血患者为研究对象，采用随机数字表法分为对照组和观察组，各43例。两组均采用无痛内镜下止血治疗，对照组联合常规剂量奥美拉唑治疗，观察组联合大剂量奥美拉唑治疗，比较两组不同时间段（8、12、24 h）止血率、止血时间、输血量、住院时间、再出血发生率、空腹胃液的pH值以及不良反应发生情况。结果 观察组8、12、24 h止血率均高于对照组，差异有统计学意义（P＜0.05）；观察组止血时间、输血量、住院时间、再出血发生率均小于对照组，差异有统计学意义（P＜0.05）；治疗8、12、24 h后，两组空腹胃液PH值均高于治疗前，且观察组高，且观察组高于对照组，差异有统计学意义（P＜0.05）；观察组不良反应发生率为6.97%，与对照组的9.30%比较，差异无统计学意义（P＞0.05）。结论 在无痛内镜下止血联合大剂量奥美拉唑治疗消化性溃疡出血效果确切，可提高止血有效率、缩短止血时间和住院时间，减少输血量，降低再出血率和空腹胃液pH值，且不会增加不良反应，应用安全性良好。
Abstract:
Objective To study the clinical efficacy and safety of painless endoscopic hemostasis combined with high-dose omeprazole in the treatment of peptic ulcer.Methods A total of 86 patients with peptic ulcer hemorrhage who were diagnosed and treated in our hospital from January 2019 to January 2020 were selected as the research objects. They were divided into control group and observation group by random number table method, with 43 cases in each group. Both groups were treated with painless endoscopic hemostasis, the control group was combined with conventional dose omeprazole treatment, and the observation group was combined with high-dose omeprazole treatment. The two groups were compared with different time periods (8, 12, 24 h) hemostasis rate, hemostasis time, blood transfusion, length of hospital stay, incidence of rebleeding, pH value of fasting gastric juice and occurrence of adverse reactions.Results The rate of hemostasis at 8, 12, and 24 h in the observation group was higher than that in the control group,the difference was statistically significant (P＜0.05); the observation group’s hemostasis time, blood transfusion volume, hospital stay, and incidence of rebleeding were all lower than those in the control group,the difference was statistically significant(P＜0.05); after 8, 12, and 24 h of treatment, the PH value of fasting gastric juice in the two groups was higher than before treatment, and the observation group was higher, and the observation group was higher than the control group, the difference was statistically significant (P＜0.05); the incidence of adverse reactions in the observation group was 6.97%, compared with 9.30% in the control group, the difference was not statistically significant (P＞0.05).Conclusion The effect of hemostasis combined with high-dose omeprazole under painless endoscopy in the treatment of peptic ulcer bleeding could improve the effective rate of hemostasis, shorten the time of hemostasis and hospital stay, reduce the amount of blood transfusion, reduce the rate of rebleeding and the pH of fasting gastric juice,and it will not increase adverse reactions, and the application safety is good.

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更新日期/Last Update: 1900-01-01