[1]林 荣,李二强.中药注射剂不良反应发生的原因分析[J].医学信息,2020,33(18):135-137.[doi:10.3969/j.issn.1006-1959.2020.18.044]
　LIN Rong,LI Er-qiang.Analysis on the Causes of Adverse Reactions of Traditional Chinese Medicine Injections[J].Medical Information,2020,33(18):135-137.[doi:10.3969/j.issn.1006-1959.2020.18.044]
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中药注射剂不良反应发生的原因分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年18期
页码:
135-137
栏目:
调查分析
出版日期:
2020-09-15

文章信息/Info

Title:
Analysis on the Causes of Adverse Reactions of Traditional Chinese Medicine Injections
文章编号:
1006-1959（2020）18-0135-03
作者:
林 荣; 李二强
（西安市高陵区中医医院药剂科，陕西 西安 710200）
Author(s):
LIN Rong; LI Er-qiang
(Department of Pharmacy,Gaoling District Traditional Chinese Medicine Hospital,Xi’an 710200,Shaanxi,China)
关键词:
中药注射剂; 不良反应; 不合理用药
Keywords:
Traditional Chinese medicine injection; Adverse reaction; Irrational drug use
分类号:
R286
DOI:
10.3969/j.issn.1006-1959.2020.18.044
文献标志码:
A
摘要:
目的 分析中药注射剂不良反应发生原因，为临床安全合理使用中药注射剂提供参考。方法 回顾性分析2018年1月~2019年12月我院使用中药注射剂治疗的546例患者的临床资料，分析药物不良反应发生情况及不同临床特征间不良反应发生情况，并采用多元线性Logistic回归分析不良反应发生的影响因素。结果 546例中药注射剂治疗患者，药物不良反应发生率为4.76%，不良反应药物主要为双黄连注射液、痰热清注射液、参麦注射液，不良反应主要为轻中度，且主要表现为变态反应；不同年龄、性别、文化程度、是否不合理用药、是否存在药物或食物过敏史患者药物不良反应发生率比较，差异有统计学意义（P＜0.05）。多元线性Logistic回归分析显示，文化程度、药物或食物过敏史、不合理用药是中药注射剂不良反应发生的高危因素。结论 中药注射剂不良反应发生原因众多，其中文化程度、药物或食物过敏史、不合理用药为其高危因素，且可控。故临床应规范、合理使用中药注射剂，有效提高中药注射剂临床用药的安全性，避免不良反应的发生。
Abstract:
Objective To analyze the causes of adverse reactions of traditional Chinese medicine injections and provide references for the safe and reasonable use of traditional Chinese medicine injections in clinical practice.Methods The clinical data of 546 patients treated with traditional Chinese medicine injections in our hospital from January 2018 to December 2019 were retrospectively analyzed, and the occurrence of adverse drug reactions and the occurrence of adverse reactions between different clinical characteristics were analyzed, and multiple linear Logistic regression was used. Analyze the influencing factors of adverse reactions.Results In 546 patients treated with traditional Chinese medicine injection, the incidence of adverse drug reactions was 4.76%. The adverse drug reactions were mainly Shuanghuanglian injection, Tanreqing injection, and Shenmai injection. The adverse reactions were mainly mild to moderate, and the main manifestations were: Allergies:the incidence of adverse drug reactions in patients with different ages, genders, education levels, whether irrational use of drugs, whether there was a history of drugs or food allergies, the difference was statistically significant (P<0.05). Multivariate linear logistic regression analysis showed that education level, history of drug or food allergies, and irrational drug use are high risk factors for adverse reactions of traditional Chinese medicine injections.Conclusion There were many reasons for the adverse reactions of traditional Chinese medicine injections, include education level, history of drug or food allergies, and irrational drug use are the high risk factor and its controllable. Therefore, the clinical application of Chinese medicine injections should be standardized and rationally used, which could effectively improve the safety of clinical use of Chinese medicine injections and avoid the occurrence of adverse reactions.

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更新日期/Last Update: 1900-01-01