[1]刘大龙,辛 燕.脑血管药物洗脱支架与金属裸支架治疗椎动脉狭窄的效果比较[J].医学信息,2020,33(23):114-115,118.[doi:10.3969/j.issn.1006-1959.2020.23.033]
　LIU Da-long,XIN Yan.Comparison of Cerebrovascular Drug-eluting Stent and Metal Bare Metal Stent in the Treatment of Vertebral Artery Stenosis[J].Medical Information,2020,33(23):114-115,118.[doi:10.3969/j.issn.1006-1959.2020.23.033]
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脑血管药物洗脱支架与金属裸支架治疗椎动脉狭窄的效果比较()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
33卷
期数:
2020年23期
页码:
114-115,118
栏目:
临床研究
出版日期:
2020-12-01

文章信息/Info

Title:
Comparison of Cerebrovascular Drug-eluting Stent and Metal Bare Metal Stent in the Treatment of Vertebral Artery Stenosis
文章编号:
1006-1959（2020）23-0114-03
作者:
刘大龙; 辛 燕
（兰州市第一人民医院神经内科1，质控科2，甘肃 兰州 730050）
Author(s):
LIU Da-long; XIN Yan
(Department of Neurology1,Department of Quality Control2,Lanzhou First People’s Hospital,Lanzhou 730050,Gansu,China)
关键词:
脑血管病; 药物洗脱支架; 金属裸支架; 椎动脉狭窄
Keywords:
Cerebrovascular disease; Drug-eluting stent; Bare metal stent; Vertebral artery stenosis
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2020.23.033
文献标志码:
A
摘要:
目的 观察研究脑血管药物洗脱支架与金属裸支架治疗椎动脉狭窄的临床疗效。方法 选取2018年2月~2019年2月在我院诊治的104例椎动脉狭窄患者为研究对象，采用随机数字表法分为对照组和观察组，各52例。对照组采用金属裸支架治疗，观察组采用脑血管药物洗脱支架治疗，比较术后6个月支架内再狭窄发生率、血流动力学指标改变（狭窄处峰值流速、狭窄处阻力指数、患侧寰椎段阻力指数）情况、Malek分级以及并发症发生情况。结果 术后6个月观察组支架内再狭窄发生率为7.67%，低于对照组的21.15%，差异有统计学意义（P＜0.05）；观察组狭窄处峰值流速、狭窄处阻力指数、患侧寰椎段阻力指数均低于对照组，差异有统计学意义（P＜0.05）；观察组Malek分级1级、2级分布率高于对照组，3级、4级低于对照组，差异有统计学意义（P＜0.05）；观察组并发症发生率为3.84%，低于对照组的11.53%，差异有统计学意义（P＜0.05）。结论 脑血管药物洗脱支架治疗椎动脉狭窄与金属裸支架比较，支架内再狭窄发生率低，可显著改善患者狭窄处血流动力学，且并发症少，应用安全性高，值得临床应用。
Abstract:
Objective To observe and study the clinical efficacy of cerebrovascular drug-eluting stents and bare metal stents in the treatment of vertebral artery stenosis.Methods A total of 104 patients with vertebral artery stenosis who were diagnosed and treated in our hospital from February 2018 to February 2019 were selected as the research objects. They were divided into a control group and an observation group by a random number table method, with 52 cases in each group.The control group was treated with bare metal stent, observation group was treated with cerebrovascular drug-eluting stent. the incidence of restenosis in the stent, hemodynamic changes (peak velocity at stenosis, resistance index at stenosis, resistance index at atlantoaxial segment of affected side), Malek grade and complications were compared after 6 months.Results 6 months postoperatively, the incidence of restenosis in the stent in the observation group was 7.67%, which was lower than 21.15% in the control group,the difference was statistically significant (P＜0.05); The resistance index of lateral atlas was lower than that of the control group,the difference was statistically significant (P＜0.05); the distribution rate of Malek grade 1 and 2 in the observation group was higher than that of the control group, and grade 3 and 4 were lower than the control group,the difference was statistically significant (P<0.05); the incidence of complications in the observation group was 3.84%, which was lower than 11.53% in the control group,the difference was statistically significant (P<0.05).Conclusion Compared with metal bare metal stents, cerebrovascular drug-eluting stents have a lower incidence of in-stent restenosis, which can significantly improve the hemodynamics of patients with stenosis, with fewer complications, and high safety. It is worthy of clinical application.

参考文献/References:

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更新日期/Last Update: 1900-01-01