[1]刘孟国,傅雯雯.警报素在系统性硬化症发病机制中的作用[J].医学信息,2021,34(04):40-44.[doi:10.3969/j.issn.1006-1959.2021.04.011]
 LIU Meng-guo,FU Wen-wen.The Role of Alarmins in the Pathogenesis of Systemic Sclerosis[J].Medical Information,2021,34(04):40-44.[doi:10.3969/j.issn.1006-1959.2021.04.011]
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警报素在系统性硬化症发病机制中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年04期
页码:
40-44
栏目:
综述
出版日期:
2021-02-15

文章信息/Info

Title:
The Role of Alarmins in the Pathogenesis of Systemic Sclerosis
文章编号:
1006-1959(2021)04-0040-05
作者:
刘孟国傅雯雯
(复旦大学附属华山医院皮肤科,上海 200040)
Author(s):
LIU Meng-guoFU Wen-wen
(Department of Dermatology,Huashan Hospital,Fudan University,Shanghai 200040,China)
关键词:
系统性硬化症警报素血管病变
Keywords:
Systemic sclerosisAlarminsVascular disease
分类号:
R758.6
DOI:
10.3969/j.issn.1006-1959.2021.04.011
文献标志码:
A
摘要:
系统性硬化症(SSc)是一种罕见的慢性自身免疫性疾病,目前关于SSc的病因和发病机制仍不清楚,普遍认为遗传、环境因素以及免疫功能异常可能与SSc发病相关,而微血管异常、免疫系统激活和氧化应激是其主要的发病机制。近年来研究发现多种介质和细胞因子参与SSc的纤维化过程,其中警报素是一种内源性和组成性表达的蛋白质/肽,在SSc发生发展中具有细胞间信号防御的作用。本文就警报素的概况、细胞核来源的警报素(HMGB-1、IL-33、IL-1及受体)、颗粒源性警报素(α和β防御素及LL-37)及细胞浆来源的警报素(HSP-70和S100)在SSc中的表达和功能作一综述,以期为该病的治疗策略提供理论性基础。
Abstract:
Systemic sclerosis (SSc) is a rare chronic autoimmune disease. At present, the etiology and pathogenesis of SSc are still unclear. It is generally believed that genetic, environmental factors, and immune function abnormalities may be related to the pathogenesis of SSc. Microvascular abnormalities, Immune system activation and oxidative stress are the main pathogenesis.In recent years, studies have found that a variety of mediators and cytokines are involved in the fibrosis process of SSc. Alarmin is an endogenous and constitutively expressed protein/peptide, which plays a role in intercellular signal defense in the development of SSc.This article discusses the overview of alarmins, nuclear-derived alarmins (HMGB-1, IL-33, IL-1 and receptors), particulate-derived alarmins (α and β defensins and LL-37), and cytoplasm-derived ones. The expression and function of alarmins (HSP-70 and S100) in SSc are reviewed in order to provide a theoretical basis for the treatment of the disease.

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更新日期/Last Update: 1900-01-01