[1]范 虹.糖尿病性视网膜病变患者血清VEGF、ES、TSP水平与眼底病变的相关性[J].医学信息,2021,34(09):119-121.[doi:10.3969/j.issn.1006-1959.2021.09.031]
　FAN Hong.Correlation Between Serum VEGF,ES,TSP Levels and Fundus Pathology in Patients with Diabetic Retinopathy[J].Medical Information,2021,34(09):119-121.[doi:10.3969/j.issn.1006-1959.2021.09.031]
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糖尿病性视网膜病变患者血清VEGF、ES、TSP水平与眼底病变的相关性()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年09期
页码:
119-121
栏目:
论著
出版日期:
2021-05-01

文章信息/Info

Title:
Correlation Between Serum VEGF,ES,TSP Levels and Fundus Pathology in Patients with Diabetic Retinopathy
文章编号:
1006-1959（2021）09-0119-03
作者:
范 虹
（天津市眼科医院综合眼科，天津 300020）
Author(s):
FAN Hong
(Department of Comprehensive Ophthalmology,Tianjin Eye Hospital,Tianjin 300020,China)
关键词:
糖尿病性视网膜病变; 血管内皮细胞生长因子; 内皮抑素; 血小板反应蛋白
Keywords:
Diabetic retinopathy; Vascular endothelial growth factor; Endostatin; Thrombospondin
分类号:
R587.2
DOI:
10.3969/j.issn.1006-1959.2021.09.031
文献标志码:
A
摘要:
目的 探讨糖尿病性视网膜病变患者血清VEGF、ES、TSP水平与眼底病变的相关性。方法 选取2018年1月~2019年12月我院收治的无眼底病变糖尿病患者40例作为无眼底病变糖尿病组、增殖性糖尿病视网膜病变患者40例作为增殖性糖尿病视网膜病变组、非增殖性糖尿病视网膜病变患者40例作为非增殖性糖尿病视网膜病变组，同时选取同期在我院进行健康体检的人群40例作为参照组，比较三组血肌酐、糖化血红蛋白、空腹血糖水平，并分析血清VEGF、ES、TSP水平与眼底病变的相关性。结果 增殖性糖尿病视网膜病变组VEGF水平高于无眼底病变糖尿病组、非增殖性糖尿病视网膜病变组、参照组，ES水平低于无眼底病变糖尿病组、非增殖性糖尿病视网膜病变组、参照组，差异有统计学意义（P＜0.05）；三组TSP水平比较，差异无统计学意义（P＞0.05）。糖尿病性视网膜病变患者血清VEGF水平与眼底病变呈正相关（r=0.456，P＜0.05），与ES、TSP水平无相关性（r=0.122、0.212，P＞0.05）。结论 糖尿病性视网膜病变患者的血清VEGF、ES、TSP水平会发生明显变化，且会通过调节VEGF水平影响糖尿病性视网膜病变进程。
Abstract:
Objective To investigate the correlation between serum VEGF, ES, TSP levels and fundus diseases in patients with diabetic retinopathy.Methods From January 2018 to December 2019, 40 diabetic patients with no fundus disease were selected as the diabetic group without fundus disease, and 40 patients with proliferative diabetic retinopathy were selected as the proliferative diabetic retinopathy group and non-proliferative diabetic retina. 40 cases of diseased patients were treated as non-proliferative diabetic retinopathy group,at the same time, 40 cases of people undergoing physical examination in our hospital during the same period were selected as the reference group.The three groups of blood creatinine, glycosylated hemoglobin, fasting blood glucose levels were compared, and the correlation between serum VEGF, ES, TSP levels and fundus lesions was analyzed.Results The blood creatinine, glycosylated hemoglobin, and fasting blood glucose levels of the proliferative diabetic retinopathy group were higher than those of the diabetic group without fundus disease and the reference group, and the course of the disease was longer than that of the diabetic group without fundus disease and the non-proliferative diabetic retinopathy group (P<0.05);Serum creatinine and fasting blood glucose levels in the proliferative diabetic retinopathy group were higher than those in the non-proliferative diabetic retinopathy group (P＜0.05);The levels of serum creatinine and glycosylated hemoglobin in the non-proliferative diabetic retinopathy group were higher than those in the diabetes group without fundus disease and the reference group, and the course of disease was longer than that in the diabetes group without fundus disease (P<0.05).The level of VEGF in the proliferative diabetic retinopathy group was higher than that of the diabetic group without fundus disease, the non-proliferative diabetic retinopathy group, and the reference group, and the ES level was lower than the diabetic group without fundus disease, the non-proliferative diabetic retinopathy group, and the reference group (P<0.05);There was no statistically significant difference in TSP levels among the three groups (P>0.05).Serum VEGF levels in patients with diabetic retinopathy were positively correlated with fundus disease (r=0.456,P＜0.05),There was no correlation with ES and TSP levels (r=0.122, 0.212, P>0.05).Conclusion The serum VEGF, ES, and TSP levels of patients with diabetic retinopathy will change significantly, and it will affect the process of diabetic retinopathy by adjusting the level of VEGF.

参考文献/References:

[1]孙琳,裴史灼,覃英梅,等.血清VEGF、ES、adropin联合检测在多囊卵巢综合征中的诊断效能[J].山东医药,2018,58(19):62-64. [2]汤娜.丹参川芎嗪注射液联合福辛普利对糖尿病肾病蛋白尿患者的临床疗效[J].中成药,2019,41(3):81-84. [3]Gurel Z,Sheibani N.O-Linked β-N-acetylglucosamine(O-GlcNAc)modification:a new pathway to decode pathogenesis of diabetic retinopathy[J].Clinical Science,2018,132(2):185-198. [4]陈盛兰,王一娜,季东贤,等.PCOS患者血清VEGF、鸢尾素、ES与患者胰岛素抵抗关系的探讨[J].中国妇产科临床杂志,2019,20(1):69-70. [5]朱丽华,李兵.二甲双胍对碱烧伤诱导大鼠角膜新生血管的抑制作用[J].眼科新进展,2018,38(1):31-34,38. [6]Feucht N,Zapp D,Reznicek L,et al.Multimodal imaging in acute retinal ischemia: spectral domain OCT,OCT-angiography and fundus autofluorescence[J].International Journal of Ophthalmology,2018,11(9):91-97. [7]钟伟芬,晏红锦,杨丽君,等.低分子肝素治疗复发性流产患者血管相关因子表达变化观测[J].广东医学,2019,40(3):358-361. [8]钱道卫,廖燕秋,李远存,等.沉默信息调节因子相关酶1（SIRT1）调控p38MARK信号通路对糖尿病视网膜病变大鼠视网膜神经节细胞的保护作用及机制[J].眼科新进展,2017,37(10):926-930. [9]He Y,Jiao W,Shi Y,et al.Segmenting Diabetic Retinopathy Lesions in Multispectral Images Using Low-Dimensional Spatial-Spectral Matrix Representation[J].IEEE Journal of Biomedical and Health Informatics,2020,24(2):493-502. [10]储继军,王瑞雪,余欣慧,等.滋肾育胎丸对RSA小鼠蜕膜组织VEGF/PI3K/Akt信号通路相关蛋白表达的影响[J].中药药理与临床,2018,34(3):161-165. [11]丁秋爱,董乐,游志鹏,等.增生型糖尿病视网膜病变患者血清及玻璃体中IL-19和VEGF表达水平的研究[J].免疫学杂志,2018,34(5):443-448. [12]Pollack S,Jr RPI,Jensen RA,et al.Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control[J].Diabetes,2019,68(2):441-456. [13]刘朝辉,高晓虹,粟改云,等.雷珠单抗对增生性糖尿病视网膜病变眼部VEGF-A、VEGF-B、PIGF及玻璃体切除术的影响[J].眼科,2018,34(4):258-263. [14]刘舒静,万光明,梁申芝,等.血清骨膜蛋白、血管内皮生长因子与糖尿病视网膜病变的关系[J].眼科新进展,2018,38(6):69-71. [15]Huang C,Fisher KP,Hammer SS,et al.Plasma Exosomes Contribute to Microvascular Damage in Diabetic Retinopathy by Activating the Classical Complement Pathway[J].Diabetes,2018,67(8):1639-1649. [16]陈小红,陈梅珠,王云鹏,等.增生型糖尿病视网膜病变患眼玻璃体腔注射雷珠单抗治疗前后房水血管内皮生长因子和色素上皮衍生因子的浓度变化[J].中华眼底病杂志,2015,31(6):560-563.

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更新日期/Last Update: 1900-01-01