参考文献/References:
[1]Labuschagne CF,Zani F,Vousden KH.Control of metabolism by p53 - Cancer and beyond[J].Biochimica et Biophysica Acta（BBA）-Reviews on Cancer,2018,1870(1):32-42. [2]江换钢,罗园,钟亚华,等.丝氨酸转运蛋白SFXN1在非小细胞肺癌中的表达及临床意义[J].肿瘤代谢与营养电子杂志,2020,7(3):301-306. [3]Geng J,Yuan X,Wei M,et al.The diverse role of TIGAR in cellular homeostasis and cancer[J].Free Radical Research,2018,52(11-12):1240-1249. [4]Chu J,Niu X,Chang J,et al.Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma[J].Theranostics,2020,10(8):3488-3502. [5]Bensaad K,Tsuruta A,Selak MA,et al.TIGAR,a p53-inducible regulator of glycolysis and apoptosis[J].Cell,2006,126(1):107-120. [6]Li H,Jogl G.Structural and Biochemical Studies of TIGAR(TP53-induced Glycolysis and Apoptosis Regulator)[J].Journal of Biological Chemistry,2009,284(3):1748-1754. [7]Bartrons R,Simon-Molas H,Rodríguez-García A,et al.Fructose 2,6-Bisphosphate in Cancer Cell Metabolism[J].Frontiers in Oncology,2018(8):331. [8]Lee P,Hock AK,Vousden KH,et al.p53- and p73-independent activation of TIGAR expression in vivo[J].Cell Death &Disease,2015,6(8):e1842. [9]Qian S,Li J,Hong M,et al.TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia[J].Journal of Hematology&Oncology,2016,9(1):128. [10]Cheung EC,Lee P,Ceteci F,et al.Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine[J].Genes &Development,2016,30(1):52-63. [11]Kim SH,Choi SI,Won KY,et al.Distinctive interrelation of p53 with SCO2,COX,and TIGAR in human gastric cancer[J].Pathology-Research and Practice,2016,212(10):904-910. [12]Sun M,Li M,Huang Q,et al.Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism[J].Neurochemistry International,2015(80):99-109. [13]Zou S,Rao Y,Chen W.miR-885-5p plays an accomplice role in liver cancer by instigating TIGAR expression via targeting its promoter[J].Biotechnology and Applied Biochemistry,2019,66(5):763-771. [14]谭业儒,伍小平,李跃华.miR-144通过靶向TIGAR调控胃癌细胞增殖与凋亡及自噬的分子机制[J].中国临床药理学杂志,2020,36(1):57-60. [15]Xu X,Liu C,Bao J.Hypoxia-induced hsa-miR-101 promotes glycolysis by targeting TIGAR mRNA in clear cell renal cell carcinoma[J].Mol Med Rep,2017,15(3):1373-1378. [16]Maurer G,Heller S,Wanka C,et al.Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator(TIGAR)Sensitizes Glioma Cells to Hypoxia,Irradiation and Temozolomide[J].International Journal of Molecular Sciences,2019,20(5):1061. [17]Hasegawa M,Sinha RK,Kumar M,et al.Intracellular Targeting of the Oncogenic MUC1-C Protein with a Novel GO-203 Nanoparticle Formulation[J].Clin Cancer Res,2015,21(10):2338-2347. [18]Ahmad R,Alam M,Hasegawa M,et al.Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer[J].Molecular Cancer,2017,16(1):33. [19]Romeo M,Hutchison T,Malu A,et al.The human T-cell leukemia virus type-1 p30 II protein activates p53 and induces the TIGAR and suppresses oncogene-induced oxidative stress during viral carcinogenesis[J].Virology,2018(518):103-115. [20]Rojo DLVM,Chapman E,Zhang DD.NRF2 and the Hallmarks of Cancer[J].Cancer Cell,2018,34(1):21-43. [21]Saikolappan S,Kumar B,Shishodia G,et al.Reactive oxygen species and cancer:A complex interaction[J].Cancer Letters,2019(452):132-143. [22]Wiel C,Le Gal K,Ibrahim MX,et al.BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis[J].Cell,2019,178(2):330-345. [23]Cheung EC,Athineos D,Lee P,et al.TIGAR is required for efficient intestinal regeneration and tumorigenesis[J].Dev Cell,2013,25(5):463-477. [24]Maddocks ODK,Athineos D,Cheung EC,et al.Modulating the therapeutic response of tumours to dietary serine and glycine starvation[J].Nature,2017,544(7650):372-376. [25]Cheung EC,Denicola GM,Nixon C,et al.Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer[J].Cancer Cell,2020,37(2):168-182. [26]Tang Z,He Z.TIGAR promotes growth,survival and metastasis through oxidation resistance and AKT activation in glioblastoma[J].Oncology Letters,2019,18(3):2509-2517. [27]Shen M,Zhao X,Zhao L,et al.Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer[J].Molecular Cancer,2018,17(1):88. [28]Zhao M,Fan J,Liu Y,et al.Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-kappaB pathway modulation[J].Int J Oncol,2016,48(2):756-764. [29]Wong EY,Wong SC,Chan CM,et al.TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells[J].Oncol Lett,2015,9(2):569-574. [30]Ko Y,Domingo-Vidal M,Roche M,et al.TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer[J].Journal of Biological Chemistry,2016,291(51):26291-26303. [31]刘赛,陈少芬,李文林,等.乳腺癌微环境成纤维细胞对乳腺癌细胞表达TIGAR和Bcl-2的影响[J].中国免疫学杂志,2018,34(2):177-182. [32]Yu H,Xie J,Li B,et al.TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway[J].Scientific Reports,2015,5(1):9853. [33]Wang X,Li R,Chen R,et al.Prognostic Values of TIGAR Expression and 18F-FDG PET/CT in Clear Cell Renal Cell Carcinoma[J].Journal of Cancer,2020,11(1):1-8. [34]Liu J,Lu F,Gong Y,et al.High expression of synthesis of cytochrome c oxidase 2 and TP53-induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma[J].Hum Pathol,2018(77):54-62. [35]Wei M,Peng J,Wu P,et al.Prognostic value of TIGAR and LC3B protein expression in nasopharyngeal carcinoma[J].Cancer Manag Res,2018(10):5605-5616. [36]Liu Z,Wu Y,Zhang Y,et al.TIGAR Promotes Tumorigenesis and Protects Tumor Cells From Oxidative and Metabolic Stresses in Gastric Cancer[J].Frontiers in Oncology,2019(9):1258. [37]Lin L,Mi Y,Li X,et al.Higher plasma concentration of TP53-induced glycolysis and apoptosis regulator is associated with a lower risk of colorectal cancer metastasis[J].Cancer Manag Res, 2018(11):263-272. [38]Yin L,Kufe T,Avigan D,et al.Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell death[J].Blood,2014,123(19):2997-3006. [39]Hong M,Xia Y,Zhu Y,et al.TP53-induced glycolysis and apoptosis regulator protects from spontaneous apoptosis and predicts poor prognosis in chronic lymphocytic leukemia[J].Leukemia Research,2016(50):72-77. [40]Huang S,Yang Z,Ma Y,et al.miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells[J].DNA and Cell Biology,2017,36(4):303-310. [41]Galluzzi L,Bravo-San PJ,Demaria S,et al.Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy[J].Nat Rev Clin Oncol,2017,14(4):247-258. [42]Ma T,Zhang Y,Zhang C,et al.Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells[J].BiochemPharmacol,2017(143):90-106. [43]Li B,Wang Z,Xie J,et al.TIGAR knockdown enhanced the anticancer effect of aescin via regulating autophagy and apoptosis in colorectal cancer cells[J].Acta Pharmacologica Sinica,2019,40(1):111-121. [44]Mao Z,Han X,Chen D,et al.Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator(TIGAR)-mediated apoptosis, autophagy, and DNA damage[J].British Journal of Pharmacology,2019,176(7):919-937. [45]Chen S,Li P,Li J,et al.MiR-144 inhibits proliferation and induces apoptosis and autophagy in lung cancer cells by targeting TIGAR[J].Cell Physiol Biochem,2015,35(3):997-1007. [46]Xie JM,Li B,Yu HP,et al.TIGAR has a dual role in cancer cell survival through regulating apoptosis and autophagy[J].Cancer Res,2014,74(18):5127-5138. [47]Kumar B,Iqbal MA,Singh RK,et al.Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy[J].Biochimie,2015(118):26-35. [48]Zhang Y,Chen F,Tai G,et al.TIGAR knockdown radiosensitizesTrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport[J].Scientific Reports,2017(7):42928. [49]Sinha S,Ghildiyal R,Mehta VS,et al.ATM-NFkappaB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFalpha[J].Cell Death Dis,2013(4):e615. [50]Lui VW,Lau CPY,Cheung CSF,et al.An RNA-directed nucleoside anti-metabolite,1-(3-C-ethynyl-beta-d-ribo-pentofuranosyl)cytosine (ECyd), elicits antitumor effect via TP53-induced Glycolysis and Apoptosis Regulator (TIGAR)downregulation[J].Biochemical Pharmacology,2010,79(12):1772-1780. [51]Fang P,De Souza C,Minn K,et al.Genome-scale CRISPR knockout screen identifies TIGAR as a modifier of PARP inhibitor sensitivity[J].Communications Biology,2019,2(1):335. [52]Fiorillo M,Sanchez-Alvarez R,Sotgia F,et al.The ER-alpha mutation Y537S confers Tamoxifen-resistance via enhanced mitochondrial metabolism,glycolysis and Rho-GDI/PTEN signaling:Implicating TIGAR in somatic resistance to endocrine therapy[J].Aging(Albany NY),2018,10(12):4000-4023.