[1]曹越越,潘跃银.吉西他滨治疗HER-2阴性转移性乳腺癌疗效的影响因素[J].医学信息,2021,34(14):70-74.[doi:10.3969/j.issn.1006-1959.2021.14.020]
 CAO Yue-yue,PAN Yue-yin.Factors Influencing the Efficacy of Gemcitabine in the Treatment of HER-2 Negative Metastatic Breast Cancer[J].Medical Information,2021,34(14):70-74.[doi:10.3969/j.issn.1006-1959.2021.14.020]
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吉西他滨治疗HER-2阴性转移性乳腺癌疗效的影响因素()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年14期
页码:
70-74
栏目:
论著
出版日期:
2021-07-15

文章信息/Info

Title:
Factors Influencing the Efficacy of Gemcitabine in the Treatment of HER-2 Negative Metastatic Breast Cancer
文章编号:
1006-1959(2021)14-0070-05
作者:
曹越越潘跃银
(1.安徽医科大学附属安徽省立医院肿瘤内科,安徽 合肥 230001; 2.中国科学技术大学附属第一医院肿瘤内科,安徽 合肥 230001)
Author(s):
CAO Yue-yuePAN Yue-yin
(1.Department of Oncology,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,Anhui,China; 2.Department of Oncology,the First Affiliated Hospital of University of Science and Technology of China,Hefei 230001,Anhui,China)
关键词:
吉西他滨转移性乳腺癌无进展生存期
Keywords:
GemcitabineMetastatic breast cancerProgression-free survival
分类号:
R737.9;R730.53
DOI:
10.3969/j.issn.1006-1959.2021.14.020
文献标志码:
A
摘要:
目的 研究HER-2阴性转移性乳腺癌患者临床特征、病理特征及其与吉西他滨疗效的相关性。方法 收集2015年5月~2020年5月在安徽省立医院接受吉西他滨治疗的HER-2阴性转移性乳腺癌患者97例。收集患者初次使用吉西他滨的年龄,原发肿瘤的激素受体表达情况、Ki-67指数,患者既往治疗史中蒽环、紫杉、辅助放疗应用情况,远处转移部位,吉西他滨治疗线数以及单药或联合用药等信息。研究终点是无进展生存期(PFS),分析吉西他滨疗效的影响因素,比较不同特征患者间PFS的差异。结果 患者的中位PFS为139 d。单因素和多因素分析结果表明,吉西他滨治疗前患者存在骨转移和吉西他滨在一、二线应用(三线及以后方案)是较长PFS的独立预测因素(P<0.05);吉西他滨单药治疗与联合用药的PFS无显著差异,仅在内脏转移的患者中联合组相比单药组PFS较长(P<0.05)。结论 HER-2阴性转移性乳腺癌患者中,存在骨转移和吉西他滨早期应用是吉西他滨疗效的独立预测因素。单药与联合用药在一线治疗方案以及骨转移患者的亚组分析中疗效相似,仅在内脏转移的患者中联合用药能有效延长吉西他滨治疗的PFS。
Abstract:
Objective To study the clinical and pathological characteristics of patients with HER-2 negative metastatic breast cancer and their correlation with the efficacy of gemcitabine.Methods A total of 97 patients with HER-2 negative metastatic breast cancer who received gemcitabine treatment in Anhui Provincial Hospital from May 2015 to May 2020 were collected.Collecting the age of the patients when they first used gemcitabine, the expression of hormone receptors in the primary tumor, Ki-67 index, the application of anthracycline, taxane, and adjuvant radiotherapy in the patient’s previous treatment history, the location of distant metastases, the number of gemcitabine treatment lines, and the number of treatments. Information about drugs or combination drugs.The endpoint of the study is progression-free survival (PFS). The factors affecting the efficacy of gemcitabine were analyzed and the differences in PFS between patients with different characteristics were compared.Results The median PFS of the patient was 139 d. The results of univariate and multivariate analysis showed that patients with bone metastases before gemcitabine treatment and gemcitabine first-line and second-line application (third-line and later regimens) were independent predictors of longer PFS (P<0.05);There was no significant difference in PFS between gemcitabine monotherapy and combination therapy. In patients with visceral metastases, the combination group had a longer PFS than the monotherapy group (P<0.05).Conclusion In patients with HER-2 negative metastatic breast cancer, the presence of bone metastasis and early use of gemcitabine are independent predictors of the efficacy of gemcitabine.The efficacy of single-drug and combination drugs was similar in the first-line treatment plan and subgroup analysis of patients with bone metastases. Only the combination of drugs in patients with visceral metastasis can effectively prolong the PFS of gemcitabine treatment.

参考文献/References:

[1]Ginsburg O,Bray F,Coleman MP,et al.The global burden of women’s cancers:a grand challenge in global health[J].Lancet,2017,389(10071):847-860. [2]Cheng Y,Yan Y,Gong J,et al.Trends in incidence and mortality of female breast cancer during transition in Central China[J].Cancer Manag Res,2018(10):6247-6255. [3]Rugo HS,Barry WT,Moreno-Aspitia A,et al.Randomized Phase III Trial of Paclitaxel Once Per Week Compared With Nanoparticle Albumin-Bound Nab-Paclitaxel Once Per Week or Ixabepilone With Bevacizumab As First-Line Chemotherapy for Locally Recurrent or Metastatic Breast Cancer:CALGB 40502/NCCTG N063H(Alliance)[J].J Clin Oncol,2015,33(21):2361-2369. [4]Chan CWH,Law BMH,So WKW,et al.Novel Strategies on Personalized Medicine for Breast Cancer Treatment:An Update[J].Int J Mol Sci,2017,18(11):2423. [5]Zhang X,Wang D,Li Z,et al.Low-Dose Gemcitabine Treatment Enhances Immunogenicity and Natural Killer Cell-Driven Tumor Immunity in Lung Cancer[J].Front Immunol,2020(11):331. [6]Gradishar WJ,Anderson BO,Abraham J,et al.Breast Cancer,Version 3.2020,NCCN Clinical Practice Guidelines in Oncology[J].J Natl Compr Canc Netw,2020,18(4):452-478. [7]Parvizpour S,Razmara J,Omidi Y.Breast cancer vaccination comes to age:impacts of bioinformatics[J].Bioimpacts,2018,8(3):223-235. [8]Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249. [9]Hernandez RK,Wade SW,Reich A,et al.Incidence of bone metastases in patients with solid tumors:analysis of oncology electronic medical records in the United States[J].BMC Cancer,2018,18(1):44. [10]Wu Q,Li J,Zhu S,et al.Breast cancer subtypes predict the preferential site of distant metastases:a SEER based study[J].Oncotarget,2017,8(17):27990-27996. [11]Salamanna F,Borsari V,Contartese D,et al.What Is the Role of Interleukins in Breast Cancer Bone Metastases?A Systematic Review of Preclinical and Clinical Evidence[J].Cancers(Basel),2019,11(12):2018. [12]孙向飞,周喜春,陈小波.LIFR基因mRNA表达对乳腺癌患者预后的判断价值[J].海南医学,2020,31(23):3046-3050. [13]Johnson RW,Finger EC,Olcina MM,et al.Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow[J].Nat Cell Biol,2016,18(10):1078-1089. [14]Dear RF,McGeechan K,Jenkins MC,et al.Combination versus sequential single agent chemotherapy for metastatic breast cancer[J].Cochrane Database Syst Rev,2013(12):Cd008792. [15]Mukai H,Ito M.Advances in chemotherapy for HER2-negative metastatic breast cancer[J].Chin Clin Oncol,2018,7(3):26. [16]Ocana A,Hortobagyi GN,Esteva FJ.Concomitant versus sequential chemotherapy in the treatment of early-stage and metastatic breast cancer[J].Clin Breast Cancer,2006,6(6):495-504. [17]Albain KS,Nag SM,Calderillo-Ruiz G,et al.Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment[J].J Clin Oncol,2008,26(24):3950-3957. [18]Seidman AD,Brufsky A,Ansari RH,et al.Phase Ⅲ trial of gemcitabine plus docetaxel versus capecitabine plus docetaxel with planned crossover to the alternate single agent in metastatic breast cancer[J].Ann Oncol,2011,22(5):1094-1101.

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更新日期/Last Update: 1900-01-01