[1]刘 琼.喹硫平治疗双相情感障碍躁狂发作的效果及对患者认知功能的影响[J].医学信息,2021,34(16):6-8.[doi:10.3969/j.issn.1006-1959.2021.16.002]
　LIU Qiong.The Effect of Quetiapine in the Treatment of Manic Episodes of Bipolar Disorder and its Influence on Patients’ Cognitive Function[J].Medical Information,2021,34(16):6-8.[doi:10.3969/j.issn.1006-1959.2021.16.002]
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喹硫平治疗双相情感障碍躁狂发作的效果及对患者认知功能的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年16期
页码:
6-8
栏目:
出版日期:
2021-08-15

文章信息/Info

Title:
The Effect of Quetiapine in the Treatment of Manic Episodes of Bipolar Disorder and its Influence on Patients’ Cognitive Function
文章编号:
1006-1959（2021）16-0006-03
作者:
刘 琼
（吉安市第三人民医院精神科，江西 吉安 343000）
Author(s):
LIU Qiong
(Department of Psychiatry,Ji’an Third People’s Hospital,Ji’an 343000,Jiangxi,China)
关键词:
双相情感障碍; 躁狂; 碳酸锂; 喹硫平; 认知功能
Keywords:
Bipolar disorder; Mania; Lithium carbonate; Quetiapine; Cognitive function
分类号:
R74
DOI:
10.3969/j.issn.1006-1959.2021.16.002
文献标志码:
A
摘要:
目的 观察应用喹硫平联合碳酸锂治疗双相情感障碍躁狂发作患者的临床效果，评估其对患者认知功能的影响。方法 选择我院2017年3月~2019年8月收治的53例双相情感障碍患者作为研究对象，采用随机数字表法分为对照组27例和观察组26例。对照组患者给予碳酸锂治疗，观察组患者则在此基础上联合喹硫平进行治疗，比较两组临床疗效、治疗前及治疗后不同时间（1、4、8周）BRMS评分、治疗前后认知功能及不良反应发生情况。结果 观察组治疗总有效率为88.46%，高于对照组的70.37%（P＜0.05）；治疗后，随着治疗时间的延长，患者的BRMS量表评分均呈下降趋势，且观察组BRMS评分低于对照组（P＜0.05）；治疗后，两组HVLTR、BVMTR、SSS、DST评分均高于治疗前，且观察组高于对照组（P＜0.05）；两组VF评分比较，差异无统计学意义（P＞0.05）；对照组不良反应总发生率高于观察组（P＜0.05）。结论 喹硫平联合碳酸锂治疗双相情感障碍躁狂发作患者临床效果显著，与单纯应用碳酸锂相比，两者联用可以改善患者的躁狂发作和精神状况；同时还可以提高患者的认知功能，不良反应少，安全性良好，值得临床应用。
Abstract:
Objective To observe the clinical effect of quetiapine combined with lithium carbonate in the treatment of patients with bipolar disorder and manic episodes, and to evaluate its impact on patients’ cognitive function.Methods 53 patients with bipolar disorder admitted to our hospital from March 2017 to August 2019 were selected as the research objects, and were divided into 27 cases in the control group and 26 cases in the observation group by random number table method.Patients in the control group were treated with lithium carbonate, and patients in the observation group were treated with quetiapine on this basis.The clinical efficacy, BRMS scores before and after treatment (1, 4, 8 weeks), cognitive function before and after treatment, and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 88.46%, which was higher than 70.37% in the control group(P＜0.05);After treatment, with the extension of the treatment time, the BRMS scores of the patients showed a downward trend, and the BRMS scores of the observation group were lower than those of the control group (P＜0.05);After treatment, the scores of HVLTR, BVMTR, SSS and DST in the two groups were higher than those before treatment, and the observation group was higher than the control group(P＜0.05);There was no statistically significant difference in VF scores between the two groups (P＞0.05);The total incidence of adverse reactions in the control group was higher than that in the observation group(P＜0.05). Conclusion The clinical effect of quetiapine combined with lithium carbonate in the treatment of bipolar disorder patients with manic episodes is significant. Compared with the simple application of lithium carbonate, the combination of the two can significantly improve the patients’ manic episodes and mental status;At the same time, it can also improve the cognitive function of patients, with few adverse reactions and good safety, which is worthy of clinical application.

参考文献/References:

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更新日期/Last Update: 1900-01-01