[1]吴亚娟,赵 楠,钱科佳,等.基于网络生物信息学筛选精神分裂症关键基因[J].医学信息,2021,34(16):1-5.[doi:10.3969/j.issn.1006-1959.2021.16.001]
　WU Ya-juan,ZHAO Nan,QIAN Ke-jia,et al.Screening Key Genes of Schizophrenia Based on Network Bioinformatics[J].Medical Information,2021,34(16):1-5.[doi:10.3969/j.issn.1006-1959.2021.16.001]
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基于网络生物信息学筛选精神分裂症关键基因()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年16期
页码:
1-5
栏目:
出版日期:
2021-08-15

文章信息/Info

Title:
Screening Key Genes of Schizophrenia Based on Network Bioinformatics
文章编号:
1006-1959（2021）16-0001-05
作者:
吴亚娟; 赵 楠; 钱科佳; 等
（张家港市第四人民医院精神科，江苏 张家港 215600）
Author(s):
WU Ya-juan; ZHAO Nan; QIAN Ke-jia; et al.
(Department of Psychiatry,Zhangjiagang Fourth People’s Hospital,Zhangjiagang 215600,Jiangsu,China)
关键词:
精神分裂症; 关键基因; 信号通路; 免疫反应
Keywords:
Schizophrenia; Key genes; Signaling pathways; Immune response
分类号:
R749.3
DOI:
10.3969/j.issn.1006-1959.2021.16.001
文献标志码:
A
摘要:
目的 利用生物信息学方法筛选参与精神分裂症发病机制的关键基因。方法 以“schizophrenia”为关键词，在大鼠基因组数据库（RGD）检索人精神分裂症相关编码基因，从生物学过程、细胞组成、分子功能三个方面分别对其进行富集分析和京都基因与基因组百科全书信号通路富集分析，然后通过构建蛋白-蛋白互作网络找到联系程度紧密的基因，通过cytosacpe软件筛选核心关键基因。结果 共检索到391个人源精神分裂症相关编码基因；这些基因主要参与STAT蛋白磷酸化、细胞和体液免疫反应、B细胞分化和增殖等生物学过程，分布于细胞连接处、神经元上、突触小泡、胞质膜的锚定成分，并主要富集于胞质DNA传感途径、RLR信号通路、自然杀伤细胞介导的细胞毒性、TOLL样受体信号通路；蛋白互作网络分析共筛选出DTNBP1、DAO、DRD2、DISC1、NRG1、ZDHHC8等6个关键基因。结论 免疫炎症反应和精神分裂症的病理机制密切相关，后续研究值得关注的通路包括TOLL样受体信号通路和NRG1信号通路，而DTNBP1和ZDHHC8与精神分裂症的直接关系还有待进一步研究。
Abstract:
Objective To screen the key genes involved in the pathogenesis of schizophrenia using bioinformatics methods.Methods Using "schizophrenia" as the key word, the human schizophrenia-related coding genes were searched in the Rat Genome Database (RGD).Enrichment analysis and Kyoto Encyclopedia of Genes and Genome Encyclopedia signal pathway enrichment analysis were carried out from the three aspects of biological process, cell composition, and molecular function.Then, the closely-connected genes are found by constructing a protein-protein interaction network, and the core key genes are screened by cytosacpe software.Results A total of 391 human-derived schizophrenia-related coding genes were retrieved;These genes were mainly involved in STAT protein phosphorylation, cellular and humoral immune response, B cell differentiation and proliferation and other biological processes. They were distributed in cell junctions, neurons, synaptic vesicles, and anchoring components of cytoplasmic membranes. Enriched in cytoplasmic DNA sensing pathway, RLR signaling pathway, natural killer cell-mediated cytotoxicity, TOLL-like receptor signaling pathway;protein interaction network analysis screened out 6 key genes including DTNBP1, DAO, DRD2, DISC1, NRG1, ZDHHC8.Conclusion The immune inflammatory response is closely related to the pathological mechanism of schizophrenia. The pathways worthy of follow-up research include TOLL-like receptor signaling pathway and NRG1 signaling pathway. The direct relationship between DTNBP1 and ZDHHC8 and schizophrenia needs further study.

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更新日期/Last Update: 1900-01-01