[1]查作霖,陈福军.MicroRNA-613调控ATOH1和FMNL2对结肠癌发生发展的影响[J].医学信息,2021,34(17):83-86.[doi:10.3969/j.issn.1006-1959.2021.17.021]
　ZHA Zuo-lin,CHEN Fu-jun.ATOH1 and FMNL2 on the Occurrence and Development of Colon Cancer[J].Medical Information,2021,34(17):83-86.[doi:10.3969/j.issn.1006-1959.2021.17.021]
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MicroRNA-613调控ATOH1和FMNL2对结肠癌发生发展的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年17期
页码:
83-86
栏目:
论著
出版日期:
2021-09-01

文章信息/Info

Title:
ATOH1 and FMNL2 on the Occurrence and Development of Colon Cancer
文章编号:
1006-1959（2021）17-0083-04
作者:
查作霖; 陈福军
（佳木斯大学附属第一医院肛肠科，黑龙江 佳木斯 154007）
Author(s):
ZHA Zuo-lin; CHEN Fu-jun
(Department of Anorectal,The First Affiliated Hospital of Jiamusi University,Jiamusi 154007,Heilongjiang,China)
关键词:
MicroRNA-613; ATOH1; FMNL2; 结肠癌
Keywords:
MicroRNA-613; ATOH1; FMNL2; Colon cancer
分类号:
R735.3
DOI:
10.3969/j.issn.1006-1959.2021.17.021
文献标志码:
A
摘要:
目的 研究在结肠癌发生发展中microRNA-613调控ATOH1和FMNL2的作用和相关性。方法 选择2019年12月-2020年12月在佳木斯大学附属第一医院肛肠科进行治疗的结肠癌患者40例作为研究对象，根据病理分化程度将其分为轻度组、重度组，各20例，取癌旁正常组织作为对照组，检测各组microRNA-613、ATOH1和FMNL2表达情况，分析microRNA-613与ATOH1和FMNL2的相关性。结果 对照组、轻度组、重度组microRNA-613表达水平逐渐升高，且各组microRNA-613表达水平比较，差异有统计学意义（P＜0.05）；对照组、轻度组、重度组FMNL2表达量逐渐降低，各组比较，差异有统计学意义（P＜0.05）；对照组、轻度组、重度组ATOH1表达量逐渐升高，各组比较，差异有统计学意义（P＜0.05）；相关性分析显示，miRNA-613与ATOH1和FMNL2均呈负相关（r=-0.581、-0.679，P<0.05）。结论 在结肠癌发生发展中microRNA-613可以调控ATOH1和FMNL2的表达，可以作为预测结肠癌发病严重程度的分子标志物。
Abstract:
Objective To study the role and correlation of microRNA-613 in regulating ATOH1 and FMNL2 in the development of colon cancer.Methods 40 patients with colon cancer who were treated in the Anorectal Department of the First Affiliated Hospital of Jiamusi University from December 2019 to December 2020 were selected as the research objects.According to the degree of pathological division, they were divided into mild group and severe group, with 20 cases in each group. Normal tissues adjacent to cancer were taken as the control group to detect the expression of microRNA-613, ATOH1 and FMNL2 in each group.Analyze the correlation between microRNA-613 and ATOH1 and FMNL2.Results The expression level of microRNA-613 in the control group, mild group, and severe group gradually increased, and the microRNA-613 expression levels in each group were compared,the difference was statistically significant(P<0.05);The expression of FMNL2 in the control group, mild group, and severe group gradually decreased,the difference between the groups was statistically significant (P<0.05);The expression of ATOH1 in the control group, mild group, and severe group gradually increased,the difference between the groups was statistically significant (P<0.05);Correlation analysis showed that miRNA-613 was negatively correlated with ATOH1 and FMNL2 (r=-0.581, -0.679,P<0.05).Conclusion MicroRNA-613 can regulate the expression of ATOH1 and FMNL2 during the occurrence and development of colon cancer, and can be used as a molecular marker for predicting the severity of colon cancer.

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更新日期/Last Update: 1900-01-01