[1]沈若兰,裴 翀,李 秀.不同程度阻塞性睡眠呼吸暂停患者嗜睡与焦虑、抑郁的相关性分析[J].医学信息,2021,34(17):87-90.[doi:10.3969/j.issn.1006-1959.2021.17.022]
　SHEN Ruo-lan,PEI Chong,LI Xiu.Correlation Analysis Between Sleepiness and Anxiety and Depression in Patients with Different Degrees of Obstructive Sleep Apnea[J].Medical Information,2021,34(17):87-90.[doi:10.3969/j.issn.1006-1959.2021.17.022]
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不同程度阻塞性睡眠呼吸暂停患者嗜睡与焦虑、抑郁的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年17期
页码:
87-90
栏目:
论著
出版日期:
2021-09-01

文章信息/Info

Title:
Correlation Analysis Between Sleepiness and Anxiety and Depression in Patients with Different Degrees of Obstructive Sleep Apnea
文章编号:
1006-1959（2021）00-0087-04
作者:
沈若兰; 裴 翀; 李 秀
（安徽医科大学第三附属医院／合肥市第一人民医院／合肥市滨湖医院呼吸内科，安徽 合肥 230061）
Author(s):
SHEN Ruo-lan; PEI Chong; LI Xiu
(Department of Respiratory Medicine,the Third Affiliated Hospital of Anhui Medical University/Hefei First People’s Hospital/ Hefei Binhu Hospital,Hefei 230061,Anhui,China)
关键词:
阻塞性睡眠呼吸暂停; 嗜睡; 焦虑; 抑郁; 多导睡眠监测
Keywords:
Obstructive sleep apnea; Drowsiness; Anxiety; Depression; Polysomnography
分类号:
R562.1
DOI:
10.3969/j.issn.1006-1959.2021.17.022
文献标志码:
A
摘要:
目的 探讨不同严重程度的阻塞性睡眠呼吸暂停（OSA）患者嗜睡与焦虑、抑郁状态的相关性。方法 选取2019年3月-2020年9月安徽医科大学第三附属医院多导睡眠监测的92例患者作为研究对象，根据多导睡眠监测结果分为轻中度OSA组（n=27）和重度OSA组（n=65）,收集患者临床资料，采用Epworth嗜睡量表（ESS）评定患者的嗜睡情况，采用焦虑量表（SAS）和抑郁量表（SDS）评定患者焦虑和抑郁状态，比较两组临床资料，并分析ESS评分与SAS评分、SDS评分及多导睡眠监测指标的相关性，SAS评分、SDS评分与一般资料、多导睡眠监测指标的相关性。结果 轻中度OSA组与重度OSA组性别、年龄、SAS评分、SDS评分比较，差异无统计学意义（P＞0.05）；重度OSA组颈围、BMI、平均血氧、ESS评分高于轻中度OSA组，平均血氧、最低血氧低于轻中度OSA组，差异有统计学意义（P＜0.05）。相关分析显示，ESS评分与AHI、SAS、SDS评分呈正相关（r=0.338、0.480、0.525，P＜0.05），与最低血氧、平均血氧呈负相关（r=-0.281、-0.249，P＜0.05）；SAS评分与颈围、BMI、AHI、最低血氧、平均血氧无相关关系（P＞0.05）；SDS评分与颈围、BMI、AHI、最低血氧、平均血氧无相关关系（P＞0.05）。结论 OSA患者的ESS评分可以反映OSA严重程度，且与焦虑、抑郁状态有相关关系。
Abstract:
Objective To explore the correlation between sleepiness and anxiety and depression in patients with obstructive sleep apnea (OSA) of different severity.Methods A total of 92 patients who underwent polysomnography in the Third Affiliated Hospital of Anhui Medical University from March 2019 to September 2020 were selected as the research objects.According to the results of polysomnography, they were divided into mild to moderate OSA group (n=27) and severe OSA group (n=65), and clinical data of patients were collected.The Epworth Sleepiness Scale (ESS) was used to assess the patient’s sleepiness, and the Anxiety Scale (SAS) and Depression Scale (SDS) were used to assess the patient’s anxiety and depression status.The clinical data of the two groups were compared, and the correlation between ESS score and SAS score, SDS score and polysomnography monitoring results, and the correlation between SAS score, SDS score and general data and PSG monitoring results were analyzed.Results There was no significant difference in gender, age, SAS score, and SDS score between the mild-moderate OSA group and the severe OSA group (P>0.05);The neck circumference, BMI, average blood oxygen, and ESS scores of the severe OSA group were higher than those of the mild-moderate OSA group, and the average blood oxygen and minimum blood oxygen were lower than those of the mild-moderate OSAHS group,the difference was statistically significant (P<0.05).Correlation analysis showed that ESS score was positively correlated with AHI, SAS, and SDS scores (r=0.338, 0.480, 0.525, P＜0.05),it was negatively correlated with minimum blood oxygen and average blood oxygen (r=-0.281, -0.249, P＜0.05);SAS score had no correlation with neck circumference, BMI, AHI, minimum blood oxygen, and average blood oxygen (P>0.05);SDS score had no correlation with neck circumference, BMI, AHI, minimum blood oxygen, and average blood oxygen (P>0.05).Conclusion ESS scores in OSA patients can reflect the severity of the disease and correlate with anxiety and depression.

参考文献/References:

[1]Sateia MJ.International classification of sleep disorders-third edition:highlights and modifications[J].Chest,2014,146(5):1387-1394. [2]Osman AM,Carter SG,Carberry JC,et al.Obstructive sleep apnea: current perspectives[J].Nat Sci Sleep,2018(10):21-34. [3]Yacoub M,Youssef I,Salifu MO,et al.Cardiovascular Disease Risk in Obstructive Sleep apnea:An Update[J].J Sleep Disord Ther,2017,7(1):283. [4]Olaithe M,Bucks RS,Hillman DR,et al.Cognitive deficits in obstructive sleep apnea:Insights from a meta-review and comparison with deficits observed in COPD,insomnia,and sleep deprivation[J].Sleep Med Rev,2018(38):39-49. [5]Saunamaki T,Jehkonen M.Depression and anxiety in obstructive sleep apnea syndrome:a review[J].Acta Neurol Scand,2007,116(5):277-288. [6]Andrade L,Caraveo-Anduaga JJ,Berglund P,et al.The epidemiology of major depressive episodes:results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys[J].Int J Methods Psychiatr Res,2003,12(1):3-21. [7]Harris M,Glozier N,Ratnavadivel R,et al.Obstructive sleep apnea and depression[J].Sleep Med Rev,2009,13(6):437-444. [8]Bjorvatn B,Rajakulendren N,Lehmann S,et al.Increased severity of obstructive sleep apnea is associated with less anxiety and depression[J].J Sleep Res,2018,27(6):e12647. [9]Zheng D,Xu Y,You S,et al.Effects of continuous positive airway pressure on depression and anxiety symptoms in patients with obstructive sleep apnoea:results from the sleep apnoea cardiovascular Endpoint randomised trial and meta-analysis[J].E Clinical Medicine,2019(11):89-96. [10]韩冰,朱建勇.阻塞性睡眠呼吸暂停低通气综合征患者心理状况研究[J].临床荟萃,2020,35(6):541-545. [11]Lee SA,Han SH,Ryu HU.Anxiety and its relationship to quality of life independent of depression in patients with obstructive sleep apnea[J].J Psychosom Res,2015,79(1):32-36. [12]齐奇,王玮,申慧,等.白日嗜睡和睡眠质量下降对阻塞性睡眠呼吸暂停患者焦虑和抑郁状态的影响[J].中华内科杂志,2019(2):119-124. [13]张明园,何燕玲.精神科评定量表手册[M].长沙:湖南科学技术出版社,2015:143-148. [14]Iber C,Ancoli-Israel S,Chesson AL,et al.The AASM Manual for the Scoring of Sleep and Associated Events:Rules,Terminology and Technical Specifications[M].Westchester,IL:American Academy of Sleep Medicine,2007:1-120. [15]Senaratna CV,Perret JL,Lodge CJ,et al.Prevalence of obstructive sleep apnea in the general population:A systematic review[J].Sleep Med Rev,2017(34):70-81. [16]Tom C,Roy B,Vig R,et al.Correlations between Waist and Neck Circumferences and Obstructive Sleep Apnea Characteristics[J].Sleep Vigil,2018,2(2):111-118. [17]李涛,姚子明,王丽,等.体脂率在阻塞性睡眠呼吸暂停评估中的作用[J].中华耳鼻咽喉头颈外科杂志,2019,54(6):427-431. [18]Dancey DR,Hanly PJ,Soong C,et al.Gender differences in sleep apnea:the role of neck circumference[J].Chest,2003,123(5):1544-1550. [19]Garbarino S,Bardwell WA,Guglielmi O,et al.Association of Anxiety and Depression in Obstructive Sleep Apnea Patients:A Systematic Review and Meta-Analysis[J].Behav Sleep Med,2020,18(1):35-57. [20]Mok Y,Melehan KL,Phillips CL,et al.Does CPAP treat depressive symptoms in individuals with OSA?An analysis of two 12-week randomized sham CPAP-controlled trials[J].Sleep Med,2020(73):11-14. [21]Jackson ML,Tolson J,Bartlett D,et al.Clinical depression in untreated obstructive sleep apnea:examining predictors and a meta-analysis of prevalence rates[J].Sleep Med,2019(62):22-28. [22]朱春明,张鹤,郑锐.阻塞性睡眠呼吸暂停低通气综合征患者嗜睡与焦虑抑郁情绪的相关性研究[J].中国基层医药,2019(4):453-456. [23]Nantakumar S,Bucks RS,Skinner TC.Are we overestimating the prevalence of depression in chronic illness using questionnaires?Meta-analytic evidence in obstructive sleep apnoea[J].Health Psychol,2016,35(5):423-432. [24]Javaheri S,Javaheri S.Update on Persistent Excessive Daytime Sleepiness in OSA[J].Chest,2020,158(2):776-786.

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更新日期/Last Update: 1900-01-01