[1]张 超,李洪静,王青青,等.HBP及24h乳酸清除率对重度脓毒症合并肺部感染患者病情转归及预后的评估价值[J].医学信息,2021,34(19):120-122.[doi:10.3969/j.issn.1006-1959.2021.19.031]
　ZHANG Chao,LI Hong-jing,WANG Qing-qing,et al.Value of HBP and 24h Lactate Clearance Rate in Evaluating Prognosis and Prognosisof Patients with Severe Sepsis Complicated with Pulmonary Infection[J].Medical Information,2021,34(19):120-122.[doi:10.3969/j.issn.1006-1959.2021.19.031]
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HBP及24h乳酸清除率对重度脓毒症合并肺部感染患者病情转归及预后的评估价值()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年19期
页码:
120-122
栏目:
临床研究
出版日期:
2021-10-01

文章信息/Info

Title:
Value of HBP and 24h Lactate Clearance Rate in Evaluating Prognosis and Prognosisof Patients with Severe Sepsis Complicated with Pulmonary Infection
文章编号:
1006-1959（2021）19-0120-03
作者:
张 超1; 李洪静2; 王青青1; 张 鑫1; 陈德鹏1; 李百腾1
1.淮安市洪泽区人民医院重症医学科，江苏 淮安 223100；2.徐州市矿务集团总医院尘肺科，江苏 徐州 221006
Author(s):
ZHANG Chao1; LI Hong-jing2; WANG Qing-qing1; ZHANG Xin1; Chen De-peng1; Li Bai-teng1
1.Intensive Care Unit,Hongze District People’s Hospital,Huai’an 223100,Jiangsu,China;2.Department of Pneumoconiosis,General Hospital of Xuzhou Mining Group,Xuzhou 221006,Jiangsu,China
关键词:
血清肝素结合蛋白; 24h乳酸清除率; 重度脓毒症; 肺部感染
Keywords:
Serum heparin binding protein; 24h lactate clearance rate; Severe sepsis; Pulmonary infection
分类号:
R631
DOI:
10.3969/j.issn.1006-1959.2021.19.031
文献标志码:
A
摘要:
目的 探讨外周血内血清肝素结合蛋白（HBP）和24h乳酸清除率（LCR）对重症脓毒症合并肺部感染者病情的预后及转归的影响。方法 选取我院2019年10月-2020年10月于急诊或ICU收治的重度脓毒症合并肺部感染患者共62例，根据患者28天预后分为存活组（37例）、死亡组（25例）。比较两组一般资料、急性生理学及慢性健康状况评估系统Ⅱ（APACHE Ⅱ）、HBP水平及24h LCR水平；采用COX生存回归分析影响重度脓毒症合并肺部感染患者病情转归和预后的危险因素；采用Pearson分析法分析APACHEⅡ评分分别与HBP水平、24h LCR水平的相关性。结果 死亡组APACHEⅡ评分及外周血内HBP水平高于存活组，24h LCR水平低于存活组，差异有统计学意义（P＜0.05）；COX生存回归单因素分析显示，高水平的HBP、APACHEⅡ评分是阻碍重度脓毒症合并肺部感染患者病情转归及预后良好的危险因素，而高效率的24h LCR是促进患者病情转归及预后良好的有利因素。COX生存回归多因素分析显示，HBP水平和24h LCR是影响重症脓毒症合并肺部感染患者病情转归和预后的独立危险因素。随着HBP的增高，患者死亡的风险增加9.50%；随着体内24h LCR增加，患者死亡的风险会降低5.70%；Pearson分析显示，APACHEⅡ评分与重度脓毒血症合并肺部感染患者外周血清HBP水平呈正相关（r=0.833，P＜0.05）；APACHEⅡ评分与重度脓毒血症合并肺部感染患者24h LCR水平呈负相关（r=-0.522，P＜0.05）。结论 外周血清内HBP水平联合24h LCR评估重症脓毒症合并肺部感染患者病情转归及预后的具有一定的价值，提高患者的评估效率。
Abstract:
Objective To investigate the effects of serum heparin binding protein (HBP) and 24h lactate clearance rate (LCR) in evaluating the prognosis and prognosis of patients with severe sepsis complicated with pulmonary infection.Methods A total of 62 patients with severe sepsis and pulmonary infection who were admitted to the emergency department or ICU in our hospital from October 2019 to October 2020 were selected. According to the 28d prognosis of the patients, they were divided into survival group (37 cases) and death group (25 cases). The general information, Acute Physiology and Chronic Health Assessment System Ⅱ (APACHE Ⅱ), HBP level and 24h LCR level were compared between the two groups; COX survival regression was used to analyze the risk factors affecting the outcome and prognosis of patients with severe sepsis and lung infection；Pearson analysis was used to analyze the correlation between APACHE Ⅱ score and HBP level and 24h LCR level.Results The APACHE Ⅱ score and peripheral blood HBP level in the death group were higher than those in the survival group, and 24h LCR level was lower than that in the survival group, and the difference was statistically significant (P<0.05); COX regression univariate analysis showed that high levels of HBP and APACHE Ⅱ scores were the risk factors for the prognosis of patients with severe sepsis complicated with pulmonary infection, and high-efficiency 24h LCR was the favorable factor for the prognosis of patients with severe sepsis complicated with pulmonary infection. Multivariate COX regression analysis showed that HBP level and 24h LCR were independent risk factors for the prognosis and prognosis of patients with severe sepsis complicated with pulmonary infection. With the increase of HBP, the risk of death increased by 9.50%, and with the increase of 24h LCR, the risk of death decreased by 5.70%. Pearson analysis showed that APACHE Ⅱ scores was positively correlated with peripheral serum HBP level in patients with severe sepsis complicated with pulmonary infection(r=0.833, P<0.05), and a negative correlation between APACHE Ⅱ score and 24h LCR level in patients with severe sepsis and pulmonary infection (r=-0.522, P<0.05).Conclusion Peripheral serum HBP level combined with 24h LCR has certain value in assessing the outcome and prognosis of patients with severe sepsis combined with pulmonary infection, and improves the efficiency of patient assessment.

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更新日期/Last Update: 1900-01-01