[1]孙 浩,谢睿恒,岳 勇.糖代谢异常与肌骨系统肿瘤恶性程度的相关性分析[J].医学信息,2021,34(19):116-119.[doi:10.3969/j.issn.1006-1959.2021.19.030]
　SUN Hao,XIE Rui-heng,YUE Yong.Analysis of the Correlation Between Abnormal Glucose Metabolism andBone Soft Tissue Tumor Malignancys[J].Medical Information,2021,34(19):116-119.[doi:10.3969/j.issn.1006-1959.2021.19.030]
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糖代谢异常与肌骨系统肿瘤恶性程度的相关性分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年19期
页码:
116-119
栏目:
论著
出版日期:
2021-10-01

文章信息/Info

Title:
Analysis of the Correlation Between Abnormal Glucose Metabolism andBone Soft Tissue Tumor Malignancys
文章编号:
1006-1959（2021）19-0116-04
作者:
孙 浩; 谢睿恒; 岳 勇
联勤保障部队第九六七医院骨科，辽宁 大连 116021
Author(s):
SUN Hao; XIE Rui-heng; YUE Yong
Department of Orthopedics,the 967th Hospital of Joint Logistics Support Force,Dalian 116021,Liaoning,China
关键词:
糖代谢; 梭形细胞瘤; 纤维瘤; 肌骨软组织; 外周神经鞘瘤
Keywords:
Glucose metabolism; Spindle cell tumor; Fibroma; Musculoskeletal soft tissue; Peripheral schwannomas
分类号:
R738
DOI:
10.3969/j.issn.1006-1959.2021.19.030
文献标志码:
A
摘要:
目的 探讨糖代谢异常对于肌骨系统肿瘤恶性程度的影响，分析其与肿瘤恶性程度的相关性。方法 回顾性分析2018年1月-12月我院骨科门诊收治的肌骨软组织源性肿瘤患者190例，收集患者入院糖代谢常规指标，肿瘤组织进行肿瘤细胞预后及耐药监测指标免疫组织化学分析，比较不同肿瘤糖代谢情况，分析糖代谢与患者肿瘤转移及p53、Bcl-2、Ki67、P-gp、GSTπ表达的相关性。结果 不同类型肿瘤患者年龄、性别、糖代谢指标及肿瘤转移情况比较，差异无统计学意义（P＞0.05），各类型肿瘤患者糖代谢异常情况比较，差异无统计学意义（P＞0.05）；单因素分析显示，糖代谢异常可能是外周神经鞘瘤（OR=4.000，95%CI：1.437~11.132）和纤维瘤（OR=4.062，95%CI：1.484~11.119）发生转移的危险因素；糖代谢异常与外周神经鞘瘤的p53﹑Bcl-2﹑Ki67﹑GSTπ表达均呈正相关（r=0.369、0.516、0.305、0.339，P＜0.05），与纤维瘤细胞的p53﹑Ki67﹑P-gp表达呈正相关（r=0.430、0.305、0.363，P＜0.05）。结论 糖代谢异常与肌骨系统来源的外周神经鞘瘤和纤维瘤的转移、预后及耐药的恶性程度密切相关，值得进一步研究。
Abstract:
Objective To investigate the correlation between abnormal glucose metabolism and malignant degree of musculoskeletal tumors.Methods From January to December 2018, 190 patients with musculoskeletal soft tissue-derived tumors were admitted to our Orthopedic Clinic. The routine indicators of glucose metabolism in patients admitted to hospital were collected, and the tumor tissues were subjected to immunohistochemical analysis of tumor cell prognosis and drug resistance monitoring indicators. The glucose metabolism in different tumors was compared, and the correlation between glucose metabolism and tumor metastasis and the expression of p53, Bcl-2, Ki67, P-gp and GSTπ was analyzed.Results There was no significant difference in age, gender, glucose metabolism index and tumor metastasis among patients with different types of tumors (P>0.05). There was no significant difference in glucose metabolism abnormality among patients with different types of tumors (P>0.05). Univariate analysis showed that abnormal glucose metabolism was a risk factor for metastasis of peripheral schwannoma (OR=4.000,95%CI:1.437-11.132) and fibroma (OR=4.062,95%CI:1.484-11.119). Abnormal glucose metabolism was positively correlated with the expression of p53, Bcl-2, Ki67 and GSTπ in peripheral schwannoma (r=0.369, 0.516, 0.305， 0.339, P<0.05), and positively correlated with the expression of p53, Ki67 and P-gp in fibroma cells (r=0.430, 0.305, 0.363, P<0.05).Conclusion Peripheral schwannoma and fibroma derived from abnormal glucose metabolism are closely related to metastasis, prognosis and malignant degree of drug resistance, which is worthy of further study and discussion.

参考文献/References:

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更新日期/Last Update: 1900-01-01