[1]王成师,何中祥,蒋书凤,等.同步放化疗在食管癌术后纵隔淋巴结转移患者中的应用[J].医学信息,2021,34(21):156-158.[doi:10.3969/j.issn.1006-1959.2021.21.044]
　WANG Cheng-shi,HE Zhong-xiang,JIANG Shu-feng,et al.Application of Concurrent Chemoradiotherapy in Patients with Mediastinal Lymph Node Metastasis After Esophagectomy[J].Medical Information,2021,34(21):156-158.[doi:10.3969/j.issn.1006-1959.2021.21.044]
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同步放化疗在食管癌术后纵隔淋巴结转移患者中的应用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年21期
页码:
156-158
栏目:
药物与临床
出版日期:
2021-11-01

文章信息/Info

Title:
Application of Concurrent Chemoradiotherapy in Patients with Mediastinal Lymph Node Metastasis After Esophagectomy
文章编号:
1006-1959（2021）21-0156-03
作者:
王成师; 何中祥; 蒋书凤; 等
（涟水县人民医院放疗科，江苏 涟水 223400）
Author(s):
WANG Cheng-shi; HE Zhong-xiang; JIANG Shu-feng; et al.
(Department of Radiotherapy,Lianshui County People’s Hospital,Lianshui 223400,Jiangsu,China)
关键词:
食管癌; 纵膈淋巴结转移; 同步放化疗; 放射性气管炎
Keywords:
Esophageal cancer; Mediastinal lymph node metastasis; Concurrent chemoradiotherapy; Radioactive bronchitis
分类号:
R735.1
DOI:
10.3969/j.issn.1006-1959.2021.21.044
文献标志码:
A
摘要:
目的 探讨食管癌术后纵隔淋巴结转移中大体肿瘤体积（GTV）＞40 cm3患者对同步放化疗的疗效。方法 选择2016年12月-2017年12月我院经筛查出现纵隔淋巴结转移且GTV＞40 cm3的食管癌术后患者66例，根据治疗方式不同分为对照组和治疗组，每组33例。对照组接受单纯三维调强放疗，治疗组接受同步化疗联合三维调强放疗，比较两组治疗疗效、生存情况及不良反应发生情况。结果 治疗组有效率高于对照组（78.79% vs 54.55%），差异有统计学意义（P＜0.05）；两组疾病控制率比较（87.88% vs 84.85%），差异无统计学意义（P＞0.05）。治疗组3年生存率高于对照组，差异有统计学意义（P＜0.05）；两组1年生存率、2年生存率比较，差异无统计学意义（P＞0.05）。两组不良反应主要为放射性气管炎、放射性肺炎、胃肠道反应和骨髓抑制，均为1、2级，无3、4级不良反应发生。两组放射性气管炎、放射性肺炎、胃肠道反应和骨髓抑制发生率比较，差异无统计学意义（P＞0.05）。结论 同步放化疗联合三维调强放疗可提高食管癌术后纵隔淋巴结转移中GTV＞40 cm3者的局部控制率及生存率，不良反应小，患者可耐受。
Abstract:
Objective To investigate the effect of concurrent radiotherapy and chemotherapy in patients with gross tumor volume (GTV)>40 cm3 in mediastinal lymph node metastases after esophageal cancer surgery.Methods A total of 66 patients with mediastinal lymph node metastasis and GTV>40 cm3 after esophageal cancer surgery in our hospital from December 2016 to December 2017 were selected and divided into control group and treatment group according to different treatment methods, with 33 cases in each group. The control group received simple three-dimensional intensity modulated radiation therapy, and the treatment group received concurrent chemotherapy combined with three-dimensional intensity modulated radiation therapy. The therapeutic efficacy, survival and adverse reactions of the two groups were compared.Results The effective rate of the treatment group was higher than that of the control group (78.79% vs 54.55%), and the difference was statistically significant (P<0.05); while there was no significant difference in disease control rate between the two groups (87.88% vs 84.85%) (P>0.05). The 3-year survival rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P<0.05), while there was no significant difference in 1-year survival rate and 2-year survival rate between the two groups (P>0.05). The adverse reactions of the two groups were mainly radiation bronchitis, radiation pneumonia, gastrointestinal reactions and bone marrow suppression, which were grade 1 and grade 2, and no grade 3 and grade 4 adverse reactions occurred; there was no significant difference in the incidence of radiation bronchitis, radiation pneumonia, gastrointestinal reaction and bone marrow suppression between the two groups (P>0.05).Conclusion Concurrent chemoradiotherapy combined with three-dimensional intensity modulated radiation therapy can improve the local control rate and survival rate of patients with GTV>40 cm3 in mediastinal lymph node metastasis after esophageal cancer surgery, with small adverse reactions and tolerable.

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更新日期/Last Update: 1900-01-01