[1]徐芳娣,高 军.Wnt/β-catenin在卵巢癌发展机制中的研究[J].医学信息,2021,34(23):22-24.[doi:10.3969/j.issn.1006-1959.2021.23.006]
 XU Fang-di,GAO Jun.Research of Wnt/β-catenin in the Development Mechanism of Ovarian Cancer[J].Medical Information,2021,34(23):22-24.[doi:10.3969/j.issn.1006-1959.2021.23.006]
点击复制

Wnt/β-catenin在卵巢癌发展机制中的研究()
分享到:

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
34卷
期数:
2021年23期
页码:
22-24
栏目:
综述
出版日期:
2021-12-01

文章信息/Info

Title:
Research of Wnt/β-catenin in the Development Mechanism of Ovarian Cancer
文章编号:
1006-1959(2021)23-0022-03
作者:
徐芳娣高 军
(1.赣南医学院,江西 赣州 410028;2.南昌大学第三附属医院,江西 南昌 330000)
Author(s):
XU Fang-diGAO Jun
(1.Gannan Medical University,Ganzhou 410028,Jiangxi,China;2.The Third Affiliated Hospital of Nanchang University,Nanchang 330000,Jiangxi,China)
关键词:
Wnt/β-连环蛋白卵巢癌蛋白分子
Keywords:
Wnt/β-cateninOvarian cancerProtein molecule
分类号:
R737.3
DOI:
10.3969/j.issn.1006-1959.2021.23.006
文献标志码:
A
摘要:
卵巢癌是女性生殖系统恶性肿瘤中死亡率最高的恶性肿瘤,早期难以发现,并易复发和耐药。Wnt/β-catenin信号通路异常激活与卵巢癌发生、发展密切相关,可通过调节Wnt/β-catenin信号通路为卵巢癌的预防和治疗提供新的策略。本文就Wnt/β-catenin通路的激活过程及其与卵巢癌的关系作一综述,以期为卵巢癌的防治提供参考。
Abstract:
Ovarian cancer is the malignant tumor with the highest mortality among the malignant tumors of the female reproductive system, which is difficult to detect in the early stage, and is easy to relapse and drug resistance. Abnormal activation of Wnt/β-catenin signaling pathway is closely related to the occurrence and development of ovarian cancer, which can provide new strategies for the prevention and treatment of ovarian cancer by regulating Wnt/β-catenin signaling pathway. This article reviews the activation process of Wnt / β-catenin pathway and its relationship with ovarian cancer, in order to provide reference for the prevention and treatment of ovarian cancer.

参考文献/References:

[1]Siegel RL,Miller KD,Fuchs HE,et al.Cancer Statistics,2021[J].CA Cancer J Clin,2021,71(1):7-33.[2]Clevers H,Nusse R.Wnt/beta-catenin signaling and disease[J].Cell,2012,149(6):1192-1205.[3]Wang L,Leung S,Talhouk A.Nuclear β-catenin and CDX2 expression in ovarian endometrioid carcinoma identify patients with favourable outcome[J].Histopathology,2019,74(3):452-462.[4]杨尊敬,杜先玲.WNT1、β-catenin、PD-L1蛋白在上皮性卵巢浆液性癌中的表达及临床意义[J].癌症进展,2019,17(17):2079-2082.[5]Wu G,Xu G,Schulman BA.Structure of a beta-TrCP1-Skp1-beta-catenin complex:destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase[J].Mol Cell,2003,11(6):1445-1456.[6]Nusse R,Clevers H.Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities[J].Cell,2017,169(6):985-999.[7]Zhang Y,Wang X.Targeting the Wnt/β-catenin signaling pathway in cancer[J].J Hematol Oncol,2020,13(1):165.[8]Shen G,Gao Q,Liu F.The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab[J].Biochem Biophys Res Commun,2020,526(3):685-691.[9]Zhang H,Sun D,Qiu J,et al.SFRP1 inhibited the epithelial ovarian cancer through inhibiting Wnt/β-catenin signaling[J].Acta Biochim Pol,2019,66(4):393-400.[10]Wang Y,Cao J,Liu W,et al.Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin[J].J Biol Chem,2019,294(48):18306-18323.[11]Croce S,Lesluyes T,Delespaul L,et al.GREB1-CTNNB1 fusion transcript detected by RNA-sequencing in a uterine tumor resembling ovarian sex cord tumor (UTROSCT):A novel CTNNB1 rearrangement[J].Genes Chromosomes Cancer,2019,58(3):155-163.[12]Liao YM,Song Y,Zhou Y,et al.SOX17,β-catenin and CyclinD1 expression in the endometrioid adenocarcinoma and influence of 5-AZA on expression[J].Cancer Gene Ther,2020,27(3-4):256-263.[13]Dong P,Zhang S,Zhang X,et al.PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition[J].J Cell Mol Med,2020,24(14):8221-8235.[14]杨宏毅.TNKS1通过Wnt/β-catenin信号通路调控卵巢癌发生发展的作用与机制[D].广州:南方医科大学,2020.[15]冯姗姗,郑洪,王凯.沉默LOXL2表达对卵巢癌SKOV3细胞生长及Wnt/β-catenin信号通路的影响[J].郑州大学学报(医学版),2020,55(1):41-44.[16]Mehdi S,Droit A,Bachvarov D.LY75 Ablation Mediates Mesenchymal-Epithelial Transition (MET) in Epithelial Ovarian Cancer (EOC) Cells Associated with DNA Methylation Alterations and Suppression of the Wnt/β-Catenin Pathway[J].Int J Mol Sci,2020,21(5):1848.[17]邓琳.cox2、wnt3a和β-catenin在子宫内膜癌及卵巢癌中的表达水平及对诊断的提示作用[D].北京:北京协和医学院,2020.[18]Zhuang XH,Liu Y,Li JL.Overexpression of long noncoding RNA HOXB-AS3 indicates an unfavorable prognosis and promotes tumorigenesis in epithelial ovarian cancer via Wnt/β-catenin signaling pathway[J].Biosci Rep,2019,39(8):BSR20190906.[19]Zhou Y,Jin Z,Wang,C.Glycogen phosphorylase B promotes ovarian cancer progression via Wnt/β-catenin signaling and is regulated by miR-133a-3p[J].Biomed Pharmacother,2019(120):109449.[20]Liu L,Ning Y,Yi J.miR-6089/MYH9/β-catenin/c-Jun negative feedback loop inhibits ovarian cancer carcinogenesis and progression[J].Biomed Pharmacother,2020(125):109865.[21]Liu HR,Zhao J.Effect and mechanism of miR-217 on drug resistance,invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing/inhibited Wnt/β-catenin signaling pathway activation[J].Eur Rev Med Pharmacol Sci,2021,25(1):94-107.[22]陈茹,苏莹,柳江.淫羊藿苷通过Wnt/β-catenin信号通路对卵巢癌细CAOV增殖的影响[J].医学研究杂志,2019,48(3):131-134.[23]龚建明,周莹巧,林琪.羟基红花黄色素A通Wnt/β-catenin信号通路抑制卵巢癌生长[J].医学研究杂志,2019,48(10):44-49.[24]Zhou B,Wang C,Liu X.Combination of nigericin with cisplatin enhances the inhibitory effect of cisplatin on epithelial ovarian cancer metastasis by inhibiting slug expression via the Wnt/beta-catenin signalling pathway[J].Oncol Lett,2021,22(4):700.

相似文献/References:

[1]杨廷双.卵巢癌患者经CT检查和MRI检查的临床效果对比[J].医学信息,2018,31(07):153.[doi:10.3969/j.issn.1006-1959.2018.07.053]
 YANG Ting-shuang.Comparison of Clinical Effects between CT and MRI in Patients with Ovarian Cancer[J].Medical Information,2018,31(23):153.[doi:10.3969/j.issn.1006-1959.2018.07.053]
[2]揭嘉慧,张 颖.卵巢癌与非编码RNA研究进展[J].医学信息,2019,32(05):39.[doi:10.3969/j.issn.1006-1959.2019.05.014]
 JIE Jia-hui,ZHANG Ying.Progress in Research on Ovarian Cancer and Non-coding RNA[J].Medical Information,2019,32(23):39.[doi:10.3969/j.issn.1006-1959.2019.05.014]
[3]林斯婕,吴 璇,覃 桓,等.卵巢癌合并2型糖尿病发生的危险因素分析[J].医学信息,2019,32(05):124.[doi:10.3969/j.issn.1006-1959.2019.05.039]
 LIN Si-jie,WU Xuan,QIN Huan,et al.Analysis of Risk Factors for Ovarian Cancer Complicated with Type 2 Diabetes[J].Medical Information,2019,32(23):124.[doi:10.3969/j.issn.1006-1959.2019.05.039]
[4]李思文,张 燕.不同紫杉醇剂型联合卡铂治疗卵巢癌的疗效研究[J].医学信息,2019,32(07):150.[doi:10.3969/j.issn.1006-1959.2019.07.046]
 LI Si-wen,ZHANG Yan.Therapeutic Effect of Different Paclitaxel Dosage Forms Combined With Carboplatin On Ovarian Cancer[J].Medical Information,2019,32(23):150.[doi:10.3969/j.issn.1006-1959.2019.07.046]
[5]许书凡,庞 华.18F-FDGPET/CT在卵巢癌中的应用研究[J].医学信息,2019,32(08):75.[doi:10.3969/j.issn.1006-1959.2019.08.022]
 XU Shu-fan,PANG Hua.Research on the Application of 18F-FDGPET/CT in Ovarian Cancer[J].Medical Information,2019,32(23):75.[doi:10.3969/j.issn.1006-1959.2019.08.022]
[6]张秀芳,陈 萍.安罗替尼联合顺铂治疗晚期卵巢癌恶性腹腔积液的疗效观察[J].医学信息,2019,32(18):132.[doi:10.3969/j.issn.1006-1959.2019.18.044]
 ZHANG Xiu-fang,CHEN Ping.Efficacy of Erlotinib Combined with Cisplatin in the Treatment of Advanced Ovarian Cancer with Malignant Ascites[J].Medical Information,2019,32(23):132.[doi:10.3969/j.issn.1006-1959.2019.18.044]
[7]许晓燕,冯 群,夏 嫱.Wnt/β-catenin信号通路在宫颈癌发生发展中的研究进展[J].医学信息,2021,34(05):1.[doi:10.3969/j.issn.1006-1959.2021.05.001]
 XU Xiao-yan,FENG Qun,XIA Qiang.Research Progress of Wnt/β-catenin Signaling Pathway in the Occurrence and Development of Cervical Cancer[J].Medical Information,2021,34(23):1.[doi:10.3969/j.issn.1006-1959.2021.05.001]
[8]黄馨禾,董丹丹,刘 倩.PARP抑制剂在卵巢癌治疗中的研究现状[J].医学信息,2019,32(21):26.[doi:10.3969/j.issn.1006-1959.2019.21.010]
 HUANG Xin-he,DONG Dan-dan,LIU Qian.Research Status of PARP Inhibitors in the Treatment of Ovarian Cancer[J].Medical Information,2019,32(23):26.[doi:10.3969/j.issn.1006-1959.2019.21.010]
[9]王 秦,张家佳,刘成桂,等.高表达IL-12卵巢癌细胞的建立[J].医学信息,2019,32(21):78.[doi:10.3969/j.issn.1006-1959.2019.21.024]
 WANG Qin,ZHANG Jia-jia,LIU Cheng-gui,et al.Establishment of High Expression of IL-12 Ovarian Cancer Cells[J].Medical Information,2019,32(23):78.[doi:10.3969/j.issn.1006-1959.2019.21.024]
[10]钟达媚,张 颖.PCG与卵巢癌关系的研究[J].医学信息,2020,33(01):28.[doi:10.3969/j.issn.1006-1959.2020.01.011]
 ZHONG Da-mei,ZHANG Ying.Study on the Relationship Between PCG and Ovarian Cancer[J].Medical Information,2020,33(23):28.[doi:10.3969/j.issn.1006-1959.2020.01.011]

更新日期/Last Update: 1900-01-01