[1]张 翠,王 喆,杨悦杰,等.利福平联合多西环素及左氧氟沙星治疗布氏菌病的疗效[J].医学信息,2022,35(03):112-114.[doi:10.3969/j.issn.1006-1959.2022.03.027]
　ZHANG Cui,WANG Zhe,YANG Yue-jie,et al.Effect of Rifampicin Combined with Doxycycline and Levofloxacin in the Treatment of Brucellosis[J].Medical Information,2022,35(03):112-114.[doi:10.3969/j.issn.1006-1959.2022.03.027]
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利福平联合多西环素及左氧氟沙星治疗布氏菌病的疗效()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年03期
页码:
112-114
栏目:
论著
出版日期:
2022-02-01

文章信息/Info

Title:
Effect of Rifampicin Combined with Doxycycline and Levofloxacin in the Treatment of Brucellosis
文章编号:
1006-1959（2022）03-0112-03
作者:
张 翠; 王 喆; 杨悦杰; 李 颖
天津市第二人民医院感染科，天津 300100
Author(s):
ZHANG Cui; WANG Zhe; YANG Yue-jie; LI Ying
Department of Infection,Tianjin Second People’s Hospital,Tianjin 300100,China
关键词:
利福平; 多西环素; 左氧氟沙星; 布氏菌病; C反应蛋白
Keywords:
Rifampicin; Doxycycline; Levofloxacin; Brucellosis; C-reactive protein
分类号:
R516.7
DOI:
10.3969/j.issn.1006-1959.2022.03.027
文献标志码:
A
摘要:
目的 观察利福平联合多西环素及左氧氟沙星治疗布氏菌病的临床疗效。方法 选取2020年3月-2021年3月我院诊治的76例布氏菌病患者为研究对象，采用随机数字表法分为对照组和观察组，各38例。对照组采用利福平联合多西环素治疗，观察组在对照组基础上联合左氧氟沙星治疗，比较两组治疗总有效率、临床症状消退时间、炎症指标[C反应蛋白（CRP）、血清降钙素原（PCT）]、复发率以及临床不良反应发生情况。结果 观察组治疗总有效率为86.84%，高于对照组的73.68%，差异有统计学意义（P＜0.05）；观察组发热、乏力、多汗、头痛、关节肿胀消退时间均短于对照组，差异有统计学意义（P＜0.05）；观察组CRP、PCT水平低于对照组，差异有统计学意义（P＜0.05）；随访2个月，观察组复发率为2.63%，低于对照组的13.16%，差异有统计学意义（P＜0.05）；两组不良反应总发生率比较，差异无统计学意义（P＞0.05）。结论 利福平联合多西环素及左氧氟沙星治疗布氏菌病效果确切，可促进临床症状消退，降低炎症指标水平和复发率，且不会增加临床不良反应几率，具有良好的应用有效性和安全性。
Abstract:
Objective To observe the clinical effect of rifampicin combined with doxycycline and levofloxacin in the treatment of brucellosis.Methods A total of 76 patients with brucellosis diagnosed and treated in our hospital from March 2020 to March 2021 were selected as the study subjects. They were divided into control group and observation group by random number table method, with 38 cases in each group. The control group was treated with rifampicin combined with doxycycline, and the observation group was treated with levofloxacin on the basis of the control group. The total effective rate, clinical symptoms subsided time, inflammatory indexes [C-reactive protein (CRP), serum procalcitonin (PCT)], recurrence rate and clinical adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 86.84%, which was higher than 73.68% of the control group, and the difference was statistically significant (P<0.05). The regression time of fever, fatigue, hyperhidrosis, headache and joint swelling in the observation group was shorter than that in the control group, and the difference was statistically significant (P<0.05). The levels of CRP and PCT in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). After two months of follow-up, the recurrence rate in the observation group was 2.63%, which was lower than 13.16% in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P>0.05).Conclusion Rifampicin combined with doxycycline and levofloxacin is effective in the treatment of brucellosis, which can promote the regression of clinical symptoms, reduce the level of inflammatory indexes and recurrence rate, and does not increase the probability of clinical adverse reactions. It has good application efficacy and safety.

参考文献/References:

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更新日期/Last Update: 1900-01-01