[1]张舒扬.双歧三联活菌联合西替利嗪治疗小儿湿疹及对其免疫球蛋白水平的影响[J].医学信息,2022,35(03):159-161.[doi:10.3969/j.issn.1006-1959.2022.03.042]
　ZHANG Shu-yang.Effect of Bifid Triple Viable Combined with Cetirizine on Immunoglobulin Levelsin Children with Atopic Dermatitis[J].Medical Information,2022,35(03):159-161.[doi:10.3969/j.issn.1006-1959.2022.03.042]
点击复制

双歧三联活菌联合西替利嗪治疗小儿湿疹及对其免疫球蛋白水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年03期
页码:
159-161
栏目:
药物与临床
出版日期:
2022-02-01

文章信息/Info

Title:
Effect of Bifid Triple Viable Combined with Cetirizine on Immunoglobulin Levelsin Children with Atopic Dermatitis
文章编号:
1006-1959（2022）03-0159-03
作者:
张舒扬
佳木斯市中心医院儿科，黑龙江 佳木斯 154000
Author(s):
ZHANG Shu-yang
Department of Pediatrics,Jiamusi Central Hospital,Jiamusi 154000,Heilongjiang,China
关键词:
小儿湿疹; 双歧三联活菌; 西替利嗪; 免疫球蛋白; 炎性因子
Keywords:
Atopic dermatitis; Bifid triple viable bacteria; Cetirizine; Immunoglobulin; Inflammatory factors
分类号:
R725
DOI:
10.3969/j.issn.1006-1959.2022.03.042
文献标志码:
A
摘要:
目的 研究双歧三联活菌联合西替利嗪治疗小儿湿疹（AD）对其免疫球蛋白水平的影响。方法 选取2020年4月-2021年4月佳木斯市中心医院儿科接诊的78例AD患儿，采用随机数字表法分为对照组与观察组，各39例。对照组给予西替利嗪治疗，观察组在其基础上联合双歧三联活菌治疗，比较两组临床疗效、肠道菌群数量、炎性因子及免疫球蛋白水平。结果 观察组治疗有效率为87.18%，高于对照组的71.79%，差异有统计学意义（P＜0.05）；观察组双歧杆菌及乳杆菌数量高于治疗前，大肠埃希菌数量低于治疗前，差异有统计学意义（P＜0.05）；两组IL-4、IL-10、IgG、IgM均低于治疗前，且观察组低于对照组，差异有统计学意义（P＜0.05）。结论 双歧三联活菌联合西替利嗪治疗AD疗效确切，可改善患儿肠道菌群，减轻机体炎性反应，提高其免疫功能。
Abstract:
Objective To study the effect of bifid triple viable combined with cetirizine on immunoglobulin levels in children with atopic dermatitis (AD).Methods A total of 78 children with AD admitted to Jiamusi Central Hospital from April 2020 to April 2021 were selected and randomly divided into control group and observation group, with 39 cases in each group. The control group was treated with cetirizine, and the observation group was treated with bifid triple viable bacteria on the basis of cetirizine. The clinical efficacy, intestinal flora, inflammatory factors and immunoglobulin levels were compared between the two groups.Results The effective rate of the observation group was 87.18%, which was higher than 71.79% of the control group, and the difference was statistically significant (P<0.05). The number of Bifidobacterium and Lactobacillus in the observation group was higher than that before treatment, and the number of Escherichia coli was lower than that before treatment, the difference was statistically significant (P<0.05). The levels of IL-4, IL-10, IgG and IgM in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group, with significant difference (P<0.05).Conclusion The combination of bifidus triple viable bacteria combined with cetirizine has a definite effect in the treatment of AD, which can improve the intestinal flora of children, reduce the body’s inflammatory response, and improve their immune function.

参考文献/References:

[1]刘建华.双歧三联活菌联合西替利嗪治疗小儿湿疹的临床效果评价[J].基层医学论坛,2020,24(10):1378-1379.[2]杜新.小儿湿疹患者运用双歧三联活菌联合西替利嗪治疗的临床效果研究[J].中国农村卫生,2021,13(2):5,7.[3]王光猛,封东进,余小红.双歧三联活菌联合西替利嗪治疗小儿湿疹的临床疗效及对肠道菌群和CD4+、CD8+水平的影响[J].世界临床药物,2020,41(12):968-972.[4]朱东宁,贾煜,杨丽娟.双歧三联活菌在小儿湿疹中的临床应用价值分析[J].中国妇幼健康研究,2017,28(11):1389-1391.[5]Czarnowicki T,Krueger JG,Guttman-Yassky E.Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march[J].The Journal of Allergy and Clinical Immunology,2017,139(6):1735-1735.[6]申春平,马琳.小儿特应性皮炎诊断与治疗[J].中国实用儿科杂志,2012,27(11):822-824.[7]杜梦斐,窦欣,陈勇.盐酸西替利嗪口服溶液联合除湿止痒洗液治疗小儿急性湿疹的临床疗效[J].中医临床研究,2020,12(35):107-109.[8]李宗尚.双歧三联活菌联合西替利嗪治疗小儿湿疹效果观察[J].皮肤病与性病,2019,41(3):412-413.[9]Orfali RL,Zaniboni MC,Aoki V.Profile of skin barrier proteins and cytokines in adults with atopic dermatitis[J].G Ital Dermatol Venereol,2017,152(2):140-147.[10]李玉娟.双歧杆菌三联活菌胶囊联合丁酸氢化可的松乳膏治疗小儿湿疹的临床效果[J].河南医学研究,2020,29(17):3174-3175.[11]孙先琳.双歧三联活菌联合西替利嗪治疗小儿湿疹的临床价值研究[J].皮肤病与性病,2018,40(4):481-482.[12]Davis KL.Reduced Th22 Cell Proportion and Prevention of Atopic Dermatitis in Infants Following Maternal Probiotic Supplementation[J].Pediatrics,2018,142(S4):S228-S229.[13]胡大毛.双歧三联活菌治疗小儿湿疹的临床效果分析[J].现代诊断与治疗,2019,30(22):3972-3974.[14]王根妹,欧阳芸,王梅装.双歧三联活菌联合西替利嗪治疗小儿湿疹的疗效分析[J].重庆医学,2017,46(3):390-391.[15]Brunner PM,Guttman-Yassky E,Leung D.The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies[J].J Allergy Clin Immunol,2017,139(4):S65-S67.[16]蒋有让,刁庆春,史丙俊,等.特应性皮炎Th1/Th2/Th17平衡的研究[J].重庆医学,2016,45(18):2482-2483.[17]徐海涛,唐瑶,贾雪峰.双歧三联活菌联合西替利嗪治疗小儿湿疹的疗效及其对血清炎性因子、免疫球蛋白水平的影响[J].中国妇幼保健,2018,33(15):3457-3459.[18]Furue M,Chiba T,Tsuji G,et al.Atopic dermatitis: immune deviation, barrier dysfunction, IgE autoreactivity and new therapies[J].Allergol Int,2017,66(3):398-403.

更新日期/Last Update: 1900-01-01