[1]王永霞,朱会芳,王明永,等.铁死亡在乳腺癌演进及治疗中的作用[J].医学信息,2022,35(05):1-5.[doi:10.3969/j.issn.1006-1959.2022.05.001]
 WANG Yong-xia,ZHU Hui-fang,WANG Ming-Yong,et al.The Role of Ferroptosis in the Progression and Treatment of Breast Cancer[J].Medical Information,2022,35(05):1-5.[doi:10.3969/j.issn.1006-1959.2022.05.001]
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铁死亡在乳腺癌演进及治疗中的作用()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年05期
页码:
1-5
栏目:
出版日期:
2022-03-01

文章信息/Info

Title:
The Role of Ferroptosis in the Progression and Treatment of Breast Cancer
文章编号:
1006-1959(2022)05-0001-05
作者:
王永霞朱会芳王明永
(1.新乡医学院第三附属医院病理科,河南 新乡 453000;2.新乡医学院基础医学院病理学系,河南 新乡 453003;3.新乡医学院检验学院,河南 新乡 453003)
Author(s):
WANG Yong-xiaZHU Hui-fangWANG Ming-Yonget al.
Breast cancer is the most common malignant tumor with high morbidity and mortality in women worldwide. Although many therapeutic approaches have been applied, the prognosis is still not satisfactory. Ferroptosis is a novel mode of non-apoptotic or non-necrosis cell death, which is mainly caused by the accumulation of iron ion and reactive oxygen species. Triggering ferroptosis of cancer cells has become a hotspot of medical research in recent years. This article reviews the merging roles of ferroptosis in the progression and therpy of breast cancer, and hope to provide references for the prevention and therpy of breast cancer.
关键词:
乳腺癌铁死亡铁离子调节性细胞死亡肿瘤演进
Keywords:
Breast cancerFerroptosisIron ionsRegulatory cell deathTumor progression
分类号:
R363;R737.9;R730.23
DOI:
10.3969/j.issn.1006-1959.2022.05.001
文献标志码:
A
摘要:
乳腺癌是全球范围内发病率和肿瘤相关死亡率均较高的一种女性恶性肿瘤。尽管目前已有多种方法用于乳腺癌的治疗,但其整体治疗效果并不十分理想。铁死亡是近年来新发现的一种不同于细胞凋亡和坏死的,依赖铁离子及活性氧诱导脂质过氧化损伤的调节性细胞死亡方式。近年来诱导肿瘤细胞铁死亡已成为医学研究热点问题之一。本文主要就铁死亡在乳腺癌演进及治疗中的作用研究进行综述,以期为其进一步的防治提供参考。
Abstract:
Breast cancer;Ferroptosis;Iron ions;Regulatory cell death;Tumor progression

参考文献/References:

[1]Sung H,Ferlay J,Siegel RL,et al.Global cancer statistics 2020: GLOBOCANestimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2021,71(3):209-249.[2]Chen WQ,Zheng RS,Baade PD,et al.Cancer statistics in China,2015[J].CA Cancer J Clin,2016,66(2):115-132.[3]Lehmann BD,Bauer JA,Chen X,et al.Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies[J].J Clin Invest,2011,121(7):2750-2767.[4]Burstein MD,Tsimelzon A,Poage GM,et al.Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer[J].Clin Cancer Res,2015,21(7):1688-1698.[5]Low SK,Zembutsu H,Nakamura Y.Breast cancer: The translation of big genomic data to cancer precision medicine[J].Cancer Sci,2018,109(3):497-506.[6]Stockwell BR,FriedmannAngeli JP,Bayir H,et al.Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease[J].Cell,2017,171(2):273-285.[7]Dixon SJ,Stockwell BR.The role of iron and reactive oxygen species in cell death[J].Nat Chem Biol,2014,10(1):9-17.[8]Bi JL,Yang SJ,Li L,et al.Metadherin enhances vulnerability of cancer cells to ferroptosis[J].Cell Death Dis,2019,10(10):682-693.[9]Liu T,Jiang L,Tavana O,et al.The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11[J].Cancer Res,2019,79(8):1913-1924.[10]Ubellacker JM,Tasdogan A,Ramesh V,et al.Lymph protects metastasizing melanoma cells from ferroptosis [J].Nature,2020,585(7823):113-118.[11]Ou W,Anwar A,Mulik R,et al.Low-density lipoprotein docosahexaenoic acid nanoparticles induce ferroptotic cell death in hepatocellular carcinoma[J].Free Radic Biol Med,2017(112):597-607.[12]Hassannia B,Vandenabeele P,VandenBerghe T.Targeting ferroptosis to iron out cancer[J].Cancer Cell,2019,35(6):830-849.[13]Dixon S,Lemberg K,Lamprecht M,et al.Ferroptosis: an iron-dependent form of nonapoptotic cell death [J].Cell,2012,149(5):1060-1072.[14]Battaglia AM,Chirillo R,Aversa I,et al.Ferroptosis and cancer: mitochondria meet the "Iron Maiden" cell death[J].Cells,2020,9(6):1505-1530.[15]Mou YH,Wang J,Wu JC,et al.Ferroptosis, a new form of cell death: opportunities and challenges in cancer[J].J Hematol Oncol,2019,12(1):34-39.[16]Torii S,Shintoku R,Kubota C,et al.An essential role for functional lysosomes in ferroptosis of cancer cells[J].Biochem J,2016,473(6):769-777.[17]Li Y,Feng DC,Wang ZY,et al.Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion[J].Cell Death Differ,2019,26(11):2284-2299.[18]Belaidi AA,Bush AI.Iron neurochemistry in Alzheimer’s disease and Parkinson’s disease: Targets for therapeutics[J].J Neurochem,2016,139(Suppl 1):179-197.[19]Ma S,Henson ES,Chen Y,et al.Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells[J].Cell Death Dis,2016,7(7):e2307.[20]Ooko E,Saeed MEM,Kadioglu O,et al.Artemisinin derivatives induce iron-dependent cell death (ferroptosis) in tumor cells[J].Phytomedicine,2015,22(11):1045-1054.[21]Qiu YM,Cao Y,Cao WJ,et al.The application of ferroptosis in diseases[J].Pharmacol Res,2020(159):104919.[22]Wu G,Fang YZ,Yang S,et al.Glutathione metabolism and its implications forhealth[J].J Nutr,2004,134(3):489-492.[23]Lu SC.Regulation of glutathione synthesis[J].Mol Aspects Med,2009,30(1-2):42-59.[24]Hatem E,El Banna N,Huang ME.Multifaceted roles of glutathione and glutathione-basedsystems in carcinogenesis and anticancer drug resistance[J].Antioxid Redox Signal,2017,27(15):1217-1234.[25]Ingold I,Berndt C,Schmitt S,et al.Selenium utilization by GPX4 Is required to prevent hydroperoxide-induced ferroptosis[J].Cell,2018,172(3):409-422.[26]Ursini F,Maiorino M,Brigelius-Flohe R,et al.Diversity of glutathione peroxidases[J].Methods Enzymol,1995(252):38-53.[27]Seiler A,Schneider M,Forster H,et al.Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-Mediated cell death[J].Cell metabolism,2008,8(3):237-248.[28]Yang WS,SriRamaratnam R,Welsch ME,et al.Regulation of ferroptoticcancercell death by GPX4[J].Cell,2014,156(1-2):317-331.[29]Wang LY,Liu YC,Du TT,et al.ATF3 promotes erastin-induced ferroptosis by suppressing system Xc[J].Cell Death Differ,2020,27(2):662-675.[30]Sui XB,Zhang RN,Liu SP,et al.RSL3 Drives Ferroptosis Through GPX4 inactivation and ROS production in colorectal cancer[J].Front Pharmacol,2018(9):1371-1378.[31]Shen Z,Song J,Yung BC,et al.Emerging strategies of cancer therapy based on ferroptosis[J].Adv Mater,2018,30(12):e1704007.[32]Xu T,Ding W,Ji XY,et al.Molecular mechanisms of ferroptosis and its role in cancer therapy[J].J Cell Mol Med,2019,23(8):4900-4912.[33]步宏,李一雷.病理学[M].第九版.北京:人民卫生出版社,2018:103-106.[34]Urooj T,Wasim B,Mushtaq S,et al.Cancer cell-derived secretory factors in breast cancer-associated lung metastasis: their mechanism and future prospects[J].Curr Cancer Drug Targets,2020,20(3):168-186.[35]DeSantis CE,Ma J,Gaudet MM,et al.Breast cancer statistics,2019[J].CA Cancer J Clin,2019,69(6):438-451.[36]Bray F,Ferlay J,Soerjomataram I,et al.Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer J Clin,2018,68(6):394-424.[37]Lin YS,Shen YC,Wu CY,et al.Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells[J]. Front Pharmacol,2019(10):1226-1238.[38]Yu HC,Yang CC,Jian L,et al.Sulfasalazine-induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor[J].Oncol Rep,2019,42(2):826-838.[39]Chen MS,Wang SF,Hsu CY,et al.CHAC1 degradation of glutathione enhances cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2-eIF2alpha-ATF4 pathway[J].Oncotarget,2017,8(70):114588-114602.[40]Lee N,Carlisle AE,Peppers A,et al.xCT-driven expression of GPX4 determines sensitivity of breast cancer cells to ferroptosisinducers[J].Antioxidants (Basel),2021,10(2):317-328.[41]Hasegawa M,Takahashi H,Rajabi H,et al.Functional interactions of the cystine/glutamate antiporter, CD44v and MUC1-C oncoprotein in triple-negative breast cancer cells[J].Oncotarget,2016,7(11):11756-11769.[42]Yadav P,Sharma P,Sundaram S,et al.SLC7A11/xCT is a target of miR-5096 and its restoration partially rescues miR-5096-mediated ferroptosis and anti-tumor effects in human breast cancer cells[J].Cancer Lett,2021(522):211-224.[43]Sun D,Li YC,Zhang XY.Lidocaine Promoted Ferroptosis by Targeting miR-382-5p /SLC7A11 Axis in Ovarian and Breast Cancer[J].Front Pharmacol,2021(12):681223-681232.[44]Hou YF,Cai S,Yu SY,et al.Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer[J].Acta Biochim Biophys Sin (Shanghai),2021,53(3):333-341.[45]Zhang HM,Ge ZC,Wang ZH,et al.Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer[J].Aging (Albany NY),2021,13(6):8115-8126.[46]Wu XH,Liu CL,Li ZHR,et al.Regulation of GSK3beta/Nrf2 signaling pathway modulated erastin-induced ferroptosis in breast cancer[J].Mol Cell Biochem,2020,473(1-2):217-228.[47]Luis G,Godfroid A,Nishiumi S,et al.Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrence[J].Redox Biol,2021,43(2021):102006-102022.[48]Yi JM,Zhu JJ,Wu J,et al.Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis [J].Proc Natl Acad Sci U S A,2020,117(49):31189-31197.[49]Lin CC,Yang WH,Lin YT,et al.DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway[J].Oncogene,2021,40(11):2018-2034.[50]Dinarvand N,Khanahmad H,Hakimian SM,et al.Evaluation of long-chain acyl-coenzyme A synthetase 4 (ACSL4) expression in human breast cancer[J].Res Pharm Sci,2020,15(1):48-56.[51]Sha R,Xu YQ,Yuan CW,et al.Predictive and prognostic impact of ferroptosis-related genes ACSL4 and GPX4 on breast cancer treated with neoadjuvantchemotherapy[J].EBio Medicine,2021(71):103560-103576.[52]Zhou YL,Yang JJ,Chen C,et al.Polyphyllin -Induced Ferroptosis in MDA-MB-231 Triple-Negative Breast Cancer Cells can Be Protected Against by KLF4-Mediated Upregulation of xCT[J].Front Pharmacol,2021(12):670224-670237.[53]Kang R,Kroemer G,Tang D.The tumor suppressor protein p53 and the ferroptosisnetwork[J].Free Radic Biol Med,2019(133):162-168.[54]Zhang Z,Lu ML,Chen CL,et al.Holo-lactoferrin: the link between ferroptosis and radiotherapy in triple-negative breast cancer[J].Theranostics,2021,11(7):3167-3182.[55]Karmi O,Sohn YS,Zandalinas SI,et al.Disrupting CISD2 function in cancer cells primarily impacts mitochondrial labile iron levels and triggers TXNIP expression[J].Free Radic Biol Med,2021(176):92-104.[56]Tang MZ,Chen Z,Wu D,et al.Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases[J].J Cell Physiol,2018,233(12):9179-9190.[57]Anastasiadi Z,Lianos GD,Ignatiadou E,et al.Breast cancer in young women: an overview[J].Updates Surg,2017,69(3):313-317.[58]Chen LY,Li XX,Liu LB,et al.Erastin sensitizes glioblastoma cells to temozolomide by restraining xCT and cystathionine-gamma-lyasefunction[J].Oncol Rep,2015,33(3):1465-1474.[59]Yamaguchi H,Hsu JL,Chen CT,et al.Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells[J].ClinCancer Res,2013,19(4):845-854.[60]Doll S,Conrad M.Iron and ferroptosis: a still ill-defined liaison [J].IUBMB Life,2017,69(6):423-434.[61]Li ZHR,Wu XH,Wang WY,et al.Fe(II) and Tannic Acid-Cloaked MOF as Carrier of Artemisinin for Supply of Ferrous Ions to Enhance Treatment of Triple-Negative Breast Cancer[J].Nanoscale Res Lett,2021,16(1):37-47.[62]Zhu JD,Dai PP,Liu F,et al.UpconvertingNanocarriers Enable Triggered Microtubule Inhibition and Concurrent Ferroptosis Induction for Selective Treatment of Triple-Negative Breast Cancer[J].Nano Lett,2020,20(9):6235-6245.[63]Li RH,Zhang J,Zhou YF,et al.Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells[J].Oxid Med Cell Longev,2020(2020):3469840-3469857.[64]Yang J,Zhou Y,Xie S,et al.Metformin induces Ferroptosis by inhibiting UFMylation of SLC7A11 in breast cancer[J].J Exp Clin Cancer Res,2021,40(1):206-224.[65]Du JJ,Wang LS,Huang XM,et al.Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells[J].Phytomedicine,2021(85):153551.[66]Kato I,Kasukabe T,Kumakura S.Menin-MLL inhibitors induce ferroptosis and enhance the anti-proliferative activity of auranofin in several types of cancer cells[J].Int J Oncol,2020,57(4):1057-1071.[67]Zhao Y,Zhao W,Lim YC,et al.Salinomycin-loaded gold nanoparticles for treating cancer stem cells by ferroptosis-induced cell death[J].Mol Pharm,2019,16(6):2532-2539.[68]Taylor WR,Fedorka SR,Gad I,et al.Small-molecule ferroptoticagents with potential to selectively target cancer stem cells[J].Sci Rep,2019,9(1):5926-5939.[69]Nagpal A,Redvers RP,Ling X,et al.Neoadjuvantneratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2(+ve) breast cancer metastasis[J]. Breast Cancer Res,2019,21(1):94-102.

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