[1]李 杰.奥美拉唑联合铝碳酸镁对反流性食管炎患者临床症状及血清胃泌素水平的影响[J].医学信息,2022,35(06):153-155.[doi:10.3969/j.issn.1006-1959.2022.06.039]
　LI Jie.Effect of Omeprazole Combined with Aluminum Magnesium Carbonate on Clinical Symptoms and Serum Gastrin Level in Patients with Reflux Esophagitis[J].Medical Information,2022,35(06):153-155.[doi:10.3969/j.issn.1006-1959.2022.06.039]
点击复制

奥美拉唑联合铝碳酸镁对反流性食管炎患者临床症状及血清胃泌素水平的影响()
分享到：

医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年06期
页码:
153-155
栏目:
药物与临床
出版日期:
2022-03-15

文章信息/Info

Title:
Effect of Omeprazole Combined with Aluminum Magnesium Carbonate on Clinical Symptoms and Serum Gastrin Level in Patients with Reflux Esophagitis
文章编号:
1006-1959（2022）06-0153-03
作者:
李 杰
（凌源市中心医院住院药局，辽宁 凌源 122500）
Author(s):
LI Jie
(Inpatient Pharmacy Bureau,Lingyuan Central Hospital,Lingyuan 122500,Liaoning,China)
关键词:
反流性食管炎; 奥美拉唑; 铝碳酸镁; 胃泌素; 胃蛋白酶原
Keywords:
Reflux esophagitis; Omeprazole; Aluminum magnesium carbonate; Gastrin; Pepsinogen
分类号:
R873.7
DOI:
10.3969/j.issn.1006-1959.2022.06.039
文献标志码:
A
摘要:
目的 分析奥美拉唑联合铝碳酸镁对反流性食管炎（RE）患者临床症状及血清胃泌素水平的影响。方法 选取2020年3月-2021年3月我院收治的84例RE患者为研究对象，采用随机数字表法分为对照组与观察组，各42例。对照组给予奥美拉唑治疗，观察组给予奥美拉唑联合铝碳酸镁治疗，比较两组症状改善程度、食管愈合疗效、血清胃蛋白酶原（PGⅠ）、胃泌素（GAS）及炎症因子（IL-1β、IL-2、IL-6）水平。结果 两组治疗后反酸、烧心、胸痛症状评分低于治疗前，且观察组低于对照组（P＜0.05）；观察组食管愈合总有效率为85.71%，高于对照组的73.81%（P＜0.05）；两组治疗后PGⅠ、GAS水平低于治疗前，且观察组低于对照组（P＜0.05）；两组治疗后IL-1β、IL-2、IL-6水平低于治疗前，且观察组低于对照组（P＜0.05）。结论 奥美拉唑联合铝碳酸镁可改善RE患者的临床症状，促进食管愈合，同时降低血清PGⅠ、GAS及炎症因子水平。
Abstract:
Objective To analyze the effect of omeprazole combined with aluminum magnesium carbonate on clinical symptoms and serum gastrin levels in patients with reflux esophagitis (RE).Methods A total of 84 patients with RE admitted to our hospital from March 2020 to March 2021 were selected as the research objects. They were divided into control group and observation group by random number table method, with 42 cases in each group. The control group was treated with omeprazole, and the observation group was treated with omeprazole combined with aluminum magnesium carbonate. The improvement of symptoms, curative effect of esophageal healing, serum pepsinogen (PGⅠ), gastrin (GAS) and inflammatory factors (IL-1β, IL-2, IL-6) levels were compared between the two groups.Results After treatment, the scores of acid reflux, heartburn and chest pain in the two groups were lower than those before treatment, and those in the observation group were lower than those in the control group (P<0.05). The total effective rate of esophageal healing in the observation group was 85.71%, which was higher than 73.81% in the control group (P<0.05). The levels of PGⅠ and GAS in the two groups after treatment were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05). The levels of IL-1β, IL-2 and IL-6 in the two groups after treatment were lower than those before treatment, and those in the observation group were lower than the control group (P<0.05).Conclusion Omeprazole combined with aluminum magnesium carbonate can improve the clinical symptoms of patients with RE, promote esophageal healing, and reduce the levels of serum PGⅠ, GAS and inflammatory factors.

参考文献/References:

[1]阿孜古力·阿不来提,梁灿灿,纪文静,等.质子泵抑制剂治疗反流性食管炎的预后影响因素分析[J].国际消化病杂志,2019,39(6):428-431.[2]余莞琳,尹华.奥美拉唑联合莫沙必利治疗反流性食管炎的疗效观察[J].中国冶金工业医学杂志,2021,38(2):220.[3]张立伟.不同质子泵抑制剂联合促胃动力药治疗反流性食管炎的疗效及安全性分析[J].中国处方药,2021,19(4):55-56.[4]Mizuno H,Yamada K,Minouchi K,et al.Efficacy of vonoprazan for 24-week maintenance therapy of patients with healed reflux esophagitis refractory to proton pump inhibitors[J].Biomed Rep,2018,8(2):148-155.[5]王瑞芳,郑玉峰,曹蕾.舒必利、奥美拉唑、铝碳酸镁联用治疗反流性胃炎的疗效及对患者血清VIP、IL-6水平的影响[J].临床医学,2020,40(5):89-91.[6]陆星华,张泰昌.反流性食管炎诊断及治疗指南(2003年)[J].中华消化内镜杂志,2004,21(4):221-222.[7]茹意.三联疗法联合健胃愈疡片在反流性食管炎患者中的应用观察[J].现代诊断与治疗,2021,32(7):1112-1113.[8]黄坚,邓家征.长期使用质子泵抑制剂对反流性食管炎小肠细菌过度生长的影响及双歧杆菌的纠正作用[J].中国临床研究,2020,33(6):784-787.[9]高小玲,靖慧军,郭文峰,等.奥美拉唑体内外给药对壁细胞H+-K+-ATP酶活性的影响[J].世界中西医结合杂志,2014,9(4):365-367.[10]余英,陈雪,孙玥,等.质子泵抑制剂治疗反流性食管炎后食管黏膜菌群构成的变化与疗效关系[J].中国临床医生杂志,2019,47(8):913-916.[11]Hoshino S,Kawami N,Takenouchi N,et al.Efficacy of Vonoprazan for Proton Pump Inhibitor-Resistant Reflux Esophagitis[J].Digestion,2017,95(2):156.[12]于莎莎.铝碳酸镁片联合埃索美拉唑肠溶片治疗活动性胃溃疡的疗效观察[J].中国冶金工业医学杂志,2021,38(3):313-314.[13]谭静.铝碳酸镁联合莫沙必利对胆汁反流性胃炎患者炎性反应细胞因子水平的影响[J].吉林医学,2020,41(10):2428-2430.[14]陈展浩,彭志华,曾利娟,等.雷贝拉唑联合莫沙必利、铝碳酸镁对反流性食管炎的治疗价值[J].深圳中西医结合杂志,2019,29(8):160-162.[15]李玲,刘容.雷贝拉唑和奥美拉唑治疗反流性食管炎的临床观察[J].医学信息,2016,29(35):240.[16]陈晓艳,李青.铝碳酸镁联合艾司奥美拉唑治疗胃溃疡伴出血患者的临床研究[J].中国临床药理学杂志,2021,37(4):370-373.[17]Di Mario F,Crafa P,Franceschi M,et al.Low Levels of Gastrin 17 are Related with Endoscopic Findings of Esophagitis and Typical Symptoms of GERD[J].J Gastrointestin Liver Dis,2021,30(1):25-29.[18]郭海军,高峰丽,王宝珍,等.枸橼酸莫沙必利联合艾司奥美拉唑治疗老年反流性食管炎的临床疗效及对血浆胃肠激素和炎性因子的影响[J].中国处方药,2020,18(11):111-113.[19]Iwakiri K.Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis[J].J Nippon Med Sch,2017,84(5):209-214.

相似文献/References:

[1]夏 铭,张正坤,曾海龙,等.四种疗法治疗幽门螺杆菌阳性消化性溃疡疗效分析[J].医学信息,2018,31(11):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
　XIA Ming,ZHANG Zheng-kun,ZENG Hai-long,et al.Therapeutic Effect of Four Kinds of Therapy on Helicobacter Pylori Positive Peptic Ulcer[J].Medical Information,2018,31(06):18.[doi:10.3969/j.issn.1006-1959.2018.11.006]
[2]吕彤观.三联疗法治疗牙周病的临床效果观察[J].医学信息,2018,31(18):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
　LV Tong-guan.Clinical Observation of Triple Therapy for Periodontosis[J].Medical Information,2018,31(06):129.[doi:10.3969/j.issn.1006-1959.2018.18.041]
[3]高华初.泮托拉唑治疗消化性溃疡合并上消化道出血的临床价值评价[J].医学信息,2018,31(22):153.[doi:10.3969/j.issn.1006-1959.2018.22.045]
　GAO Hua-chu.Clinical Value of Pantoprazole in the Treatment of Peptic Ulcer Complicated with Upper Gastrointestinal Bleeding[J].Medical Information,2018,31(06):153.[doi:10.3969/j.issn.1006-1959.2018.22.045]
[4]高华初.奥美拉唑与西咪替丁治疗应激性胃溃疡的疗效观察[J].医学信息,2018,31(23):136.[doi:10.3969/j.issn.1006-1959.2018.23.039]
　GAO Hua-chu.Efficacy of Omeprazole and Cimetidine in the Treatment of Stress Gastric Ulcer[J].Medical Information,2018,31(06):136.[doi:10.3969/j.issn.1006-1959.2018.23.039]
[5]张宏程.磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床疗效观察[J].医学信息,2019,32(02):150.[doi:10.3969/j.issn.1006-1959.2019.02.044]
　ZHANG Hong-cheng.Clinical Efficacy of Aluminum Phosphate Gel Combined with Omeprazole in the Treatment of Peptic Ulcer[J].Medical Information,2019,32(06):150.[doi:10.3969/j.issn.1006-1959.2019.02.044]
[6]李会颖.奥美拉唑联合多潘立酮治疗哮喘合并胃食管反流病的效果[J].医学信息,2020,33(09):144.[doi:10.3969/j.issn.1006-1959.2020.09.047]
　LI Hui-ying.Effect of Omeprazole Combined with Domperidone on Asthma Combined with Gastroesophageal Reflux Disease[J].Medical Information,2020,33(06):144.[doi:10.3969/j.issn.1006-1959.2020.09.047]
[7]任 琳.雷尼替丁和奥美拉唑治疗浅表性胃炎的效果比较[J].医学信息,2020,33(12):141.[doi:10.3969/j.issn.1006-1959.2020.12.044]
　REN Lin.Ranitidine and Omeprazole in the Treatment of Superficial Gastritis[J].Medical Information,2020,33(06):141.[doi:10.3969/j.issn.1006-1959.2020.12.044]
[8]刘小娟.大剂量奥美拉唑治疗消化性溃疡出血的有效性与安全性[J].医学信息,2020,33(17):143.[doi:10.3969/j.issn.1006-1959.2020.17.041]
　LIU Xiao-juan.Efficacy and Safety of High-dose Omeprazole in the Treatment of Peptic Ulcer Bleeding[J].Medical Information,2020,33(06):143.[doi:10.3969/j.issn.1006-1959.2020.17.041]
[9]张树慧,李建波.加味四逆散联合针灸疗法治疗反流性食管炎的效果[J].医学信息,2020,33(17):166.[doi:10.3969/j.issn.1006-1959.2020.17.050]
　ZHANG Shu-hui,LI Jian-bo.Effect of Jiawei Sini San and Acupuncture Therapy on Reflux Esophagitis[J].Medical Information,2020,33(06):166.[doi:10.3969/j.issn.1006-1959.2020.17.050]
[10]陈艳玲.奥美拉唑、兰索拉唑与泮托拉唑治疗胃炎胃溃疡的效果及安全性[J].医学信息,2022,35(10):134.[doi:10.3969/j.issn.1006-1959.2022.10.032]
　CHEN Yan-ling.Effect and Safety of Omeprazole, Lansoprazole and Pantoprazole in the Treatment of Gastritis and Gastric Ulcer[J].Medical Information,2022,35(06):134.[doi:10.3969/j.issn.1006-1959.2022.10.032]

更新日期/Last Update: 1900-01-01