[1]金 英.血浆置换联合大剂量甲泼尼龙对特发性血小板减少性紫癜患者血小板相关免疫球蛋白及T细胞亚群的影响[J].医学信息,2022,35(09):131-133.[doi:10.3969/j.issn.1006-1959.2022.09.032]
　JIN Ying.Effect of Plasma Exchange Combined with High-dose Methylprednisolone on Platelet-related Immunoglobulin and T Cell Subsets in Patients with Idiopathic Thrombocytopenic Purpura[J].Medical Information,2022,35(09):131-133.[doi:10.3969/j.issn.1006-1959.2022.09.032]
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血浆置换联合大剂量甲泼尼龙对特发性血小板减少性紫癜患者血小板相关免疫球蛋白及T细胞亚群的影响()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年09期
页码:
131-133
栏目:
论著
出版日期:
2022-05-01

文章信息/Info

Title:
Effect of Plasma Exchange Combined with High-dose Methylprednisolone on Platelet-related Immunoglobulin and T Cell Subsets in Patients with Idiopathic Thrombocytopenic Purpura
文章编号:
1006-1959（2022）09-0131-03
作者:
金 英
（佳木斯市中心医院血液内科，黑龙江 佳木斯 154002）
Author(s):
JIN Ying
(Department of Hematology,Jiamusi Central Hospital,Jiamusi 154002,Heilongjiang,China)
关键词:
血浆置换; 甲泼尼龙; 特发性血小板减少性紫癜; T细胞亚群
Keywords:
Plasma exchange; Methylprednisolone; Idiopathic thrombocytopenic purpura; T cell subsets
分类号:
R558
DOI:
10.3969/j.issn.1006-1959.2022.09.032
文献标志码:
A
摘要:
目的 探讨血浆置换联合大剂量甲泼尼龙对特发性血小板减少性紫癜患者血小板相关免疫球蛋白及T细胞亚群的影响。方法 选取2020年6月-2021年6月我院收治的特发性血小板减少性紫癜患者150例，应用随机数字法分为对照组和观察组，各75例。对照组在常规基础上给予甲泼尼龙治疗，观察组在对照组基础上联合血浆置换治疗，比较两组治疗效果、血小板、血小板相关免疫球蛋白、T细胞亚群及不良反应发生率。结果 观察组总有效率为82.67%，高于对照组的58.67%，差异有统计学意义（P＜0.05）；观察组PLT高于对照组，PAIgG、PAIgA、PAIgM低于对照组，差异有统计学意义（P＜0.05）；观察组CD3、CD4、CD4/CD8高于对照组，CD8低于对照组，差异有统计学意义（P＜0.05）；观察组不良反应总发生率为4.00%，低于对照组的20.00%，差异有统计学意义（P＜0.05）。结论 血浆置换联合大剂量甲泼尼龙治疗特发性血小板减少性紫癜的疗效确切，可改善患者血小板相关免疫球蛋白及T细胞亚群水平，且安全性较高。
Abstract:
Objective To investigate the effect of plasma exchange combined with high-dose methylprednisolone on platelet-related immunoglobulin and T cell subsets in patients with idiopathic thrombocytopenic purpura.Methods A total of 150 patients with idiopathic thrombocytopenic purpura admitted to our hospital from June 2020 to June 2021 were randomly divided into control group and observation group, with 75 cases in each group. The control group was treated with methylprednisolone on the basis of conventional treatment, and the observation group was treated with plasma exchange on the basis of the control group. The therapeutic effect, platelet, platelet-related immunoglobulin, T cell subsets and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 82.67%, which was higher than 58.67% of the control group, and the difference was statistically significant (P<0.05). PLT in the observation group was higher than that in the control group, and PAIgG, PAIgA and PAIgM were lower than those in the control group, the difference was statistically significant (P<0.05). CD3, CD4 and CD4/CD8 in the observation group were higher than those in the control group, and CD8 was lower than that in the control group, the difference was statistically significant (P<0.05). The total incidence of adverse reactions in the observation group was 4.00%, which was lower than 20.00% in the control group, and the difference was statistically significant (P<0.05).Conclusion Plasma exchange combined with high-dose methylprednisolone is effective in the treatment of idiopathic thrombocytopenic purpura, which can improve the levels of platelet-related immunoglobulin and T cell subsets in patients with high safety.

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更新日期/Last Update: 1900-01-01