[1]刘 颖,杨志高,李慧琼,等.肠内联合肠外营养与肠内营养支持治疗COPD机械通气患者疗效比较的Meta分析[J].医学信息,2022,35(10):98-104.[doi:10.3969/j.issn.1006-1959.2022.10.024]
　LIU Ying,YANG Zhi-gao,LI Hui-qiong,et al.Meta-analysis of the Efficacy of Enteral Combined Parenteral Nutrition and Enteral Nutrition Support in the Treatment of COPD Patients with Mechanical Ventilation[J].Medical Information,2022,35(10):98-104.[doi:10.3969/j.issn.1006-1959.2022.10.024]
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肠内联合肠外营养与肠内营养支持治疗COPD机械通气患者疗效比较的Meta分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年10期
页码:
98-104
栏目:
论著
出版日期:
2022-05-15

文章信息/Info

Title:
Meta-analysis of the Efficacy of Enteral Combined Parenteral Nutrition and Enteral Nutrition Support in the Treatment of COPD Patients with Mechanical Ventilation
文章编号:
1006-1959（2022）10-0098-07
作者:
刘 颖; 杨志高; 李慧琼; 等
（国药葛洲坝中心医院老年医学科，湖北 宜昌 443000）
Author(s):
LIU Ying; YANG Zhi-gao; LI Hui-qiong; et al.
(Department of Geriatrics,Sinopharm Gezhouba Central Hospital,Yichang 443000,Hubei,China)
关键词:
肠内营养; 肠外营养; COPD; 机械通气
Keywords:
Enteral nutrition; Parenteral nutrition; COPD; Mechanical ventilation
分类号:
R459.3；R563
DOI:
10.3969/j.issn.1006-1959.2022.10.024
文献标志码:
A
摘要:
目的 比较肠内联合肠外营养与肠内营养对COPD机械通气患者的疗效，以期为COPD机械通气患者的临床治疗提供循证医学证据。方法 利用计算机检索中国知网数据库（CNKI）、万方数据库、维普中文科技期刊全文数据库（VIP）、中国生物医学文献数据库（CBM）、PubMed、EMbase、Web of Science、Cochrane Library，收集肠内联合肠外营养与肠内营养治疗COPD机械通气患者疗效比较的相关文献，提取数据，最后利用RevMan 5.3软件对所提取文献的数据进行统计学分析。结果 Meta分析的结果显示，试验组在提高血清白蛋白浓度[MD=3.14，95%CI=（1.50，4.77），Z=3.76，P＜0.05]、撤机成功率[OR=2.12，95%CI=（1.41，3.21），Z=3.58，P＜0.05]，降低VAP发生率[OR=0.29，95%CI=（0.16，0.54），Z=3.93，P＜0.0001]、28 d死亡率[OR=0.27，95%CI=（0.13，0.54），Z=3.72，P＜0.0001]方面优于对照组；在提升免疫球蛋白G浓度[MD=0.79，95%CI=（-0.50，2.09），Z=1.20，P＞0.05]方面与对照组比较，差异无统计学意义。结论 COPD机械通气患者肠内联合肠外营养的营养支持治疗在提高血清白蛋白、撤机成功率、降低28 d死亡率和VAP发生率方面优于肠内营养，且疗效更为显著。二者在提高IgG浓度方面的治疗效果相似。
Abstract:
Objective To compare the efficacy of enteral combined with parenteral nutrition and enteral nutrition in patients with COPD mechanical ventilation, in order to provide evidence-based medical evidence for the clinical treatment of patients with COPD mechanical ventilation.Methods China knowledge net database (CNKI), Wanfang database, VIP Chinese sci-tech periodical full-text database (VIP), Chinese biomedical literature database (CBM)， PubMed， Embase， Web of Science and Cochrane Library were searched to collect the related literatures about the efficacy of enteral combined parenteral nutrition and enteral nutrition in the treatment of COPD patients with mechanical ventilation, and the data were extracted. Finally, the data of the extracted literature were statistically analyzed by Revman 5.3 software.Results The results of Meta-analysis showed that the experimental group was superior to the control group in improving serum albumin concentration [MD=3.14,95%CI=(1.50,4.77),Z=3.76,P<0.05], weaning success rate [OR=2.12,95%CI=(1.41,3.21),Z=3.58,P<0.05], reducing the incidence of VAP [OR=0.29,95%CI=(0.16,0.54),Z=3.93,P<0.0001] and 28 d mortality [OR=0.27,95%CI=(0.13,0.54),Z=3.72,P<0.0001]. There was no significant difference between the experimental group and the control group in increasing the concentration of immunoglobulin G [MD=0.79,95%CI=(-0.50,2.09),Z=1.20,P>0.05].Conclusion The nutritional support therapy of enteral combined with parenteral nutrition in COPD patients with mechanical ventilation is superior to enteral nutrition in improving serum albumin, weaning success rate, reducing 28 d mortality and VAP incidence, and the curative effect is more obvious. Both have similar therapeutic effects in increasing IgG concentration.

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更新日期/Last Update: 1900-01-01