[1]韩捷思.流感样病例中流感病毒阳性检出率的影响因素分析[J].医学信息,2022,35(17):12-15.[doi:10.3969/j.issn.1006-1959.2022.17.003]
　HAN Jie-si.Analysis on Influencing Factors of Positive Detection Rate of Influenza Virus in Influenza-like Illness[J].Journal of Medical Information,2022,35(17):12-15.[doi:10.3969/j.issn.1006-1959.2022.17.003]
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流感样病例中流感病毒阳性检出率的影响因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
12-15
栏目:
医学数据科学
出版日期:
2022-09-01

文章信息/Info

Title:
Analysis on Influencing Factors of Positive Detection Rate of Influenza Virus in Influenza-like Illness
文章编号:
1006-1959（2022）17-0012-04
作者:
韩捷思
（天津市蓟州区疾病预防控制中心业务办公室，天津 301900）
Author(s):
HAN Jie-si
(Business Office of Tianjin Jizhou District Center for Disease Control and Prevention,Tianjin 301900,China)
关键词:
流感病毒; 咽拭子; 阳性检出率; 标本采集; 采样时间; 荧光定量PCR法
Keywords:
Influenza virus; Throat swab; Positive detection rate; Specimen collection; Sampling time; Fluorescence quantitative PCR
分类号:
R511.7
DOI:
10.3969/j.issn.1006-1959.2022.17.003
文献标志码:
A
摘要:
目的 分析流感样病例中流感病毒阳性检出率的相关影响因素。方法 于全国流感监测网络系统中收集2018年1月-2020年12月采集的1815份流感样病例咽拭子样本，所有样本均采用实时荧光定量PCR（Real-time PCR）法完成核酸检测，统计其阳性检出率，并对其相关影响因素进行分析。结果 1815份流感样病例咽拭子样本的检测总阳性率为13.06%；流感样病例分年龄段阳性检出率由高到低依次为15~35岁、35岁及以上、14岁及以下；采样时间阳性检出率由高到低依次为第一季度、第四季度、第二季度、第三季度；发病、采样与送检的时间间隔时间越短，阳性检出率越高，差异有统计学意义（P＜0.05）；多因素Logistic回归分析显示，流感样病例年龄（OR=1.064，95%CI：0.968~1.354）、采样时间（OR=1.342，95%CI：0.975~1.659）、采样至送检时间（OR=1.476，95%CI：1.362~1.603）为流感阳性检出的危险因素。结论 流感样病例的年龄、采样时间、采样至送检时间可影响其流感阳性检出率。
Abstract:
Objective To analyze the related influencing factors of positive detection rate of influenza virus in influenza-like illness.Methods Throat swab samples of 1815 influenza-like cases collected from January 2018 to December 2020 were collected from the national influenza surveillance network system. All samples were tested for nucleic acid by real-time fluorescence quantitative PCR (Real-time PCR). The positive detection rate was counted and its related influencing factors were analyzed.Results The total positive rate of 1815 throat swab samples was 13.06%. The positive detection rate of influenza-like illness in different age groups from high to low was 15-35 years old, 35 years old and above, 14 years old and below; the positive rate of sampling time from high to low was the first quarter, the fourth quarter, the second quarter, the third quarter; the shorter the time interval between onset, sampling and submission, the higher the positive detection rate, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that age (OR=1.064,95%CI:0.968-1.354), sampling time (OR=1.342,95%CI:0.975-1.659) and time from sampling to submission (OR=1.476,95%CI:1.362-1.603) were risk factors for positive detection of influenza.Conclusion The age, sampling time and sampling to submission time of influenza-like illness can affect the positive detection rate of influenza.

参考文献/References:

[1]唐钧,曹红梅.甲型H1N1流感病毒RNA检测方法的建立及临床应用[J].检验医学,2021,36(7):738-742.[2]Bui CM,Chughtai AA,Adam DC,et al.An overview of the epidemiology and emergence of influenza A infection in humans over time[J].Archives of Public Health,2017,75(1):15.[3]陆丽芬,盛迪,朱春婷,等.发热门诊中流行性感冒病毒检测阳性912例临床特征分析[J].中华危重症医学杂志(电子版),2021,14(1):60-62.[4]刘宁,张立丽,赵艳明,等.2016-2018年某院甲、乙型流感病毒流行病学特点及检测方法比较[J].检验医学与临床,2019,16(2):184-186,190.[5]郑雅旭,姜晨彦,毛盛华,等.流感样病例定义对流感监测结果影响的比较分析[J].中华疾病控制杂志,2017,21(9):895-899.[6]李珺,刘亚楠,田国保,等.临床实验室流感病毒检测的相关影响因素分析[J].国际病毒学杂志,2017,24(5):331-335.[7]中华人民共和国卫生部.全国流感监测方案(2010年版)[J].国际呼吸杂志,2011,1(2):85-88.[8]闭福银,王静,康宁,等.广西流感样病例呼吸道病毒检测结果分析[J].应用预防医学,2018,24(6):473-475.[9]Iuliano AD,Roguski KM,Chang HH,et al.Estimates of global seasonal influenza-associated respiratory mortality: a modelling study[J].The Lancet,2018,391(1):1285.[10]高鑫,朱武洋,卢学新.实时荧光定量PCR在病毒检测中的应用[J].中国人兽共患病学报,2018,34(7):660-667.[11]陈晨,范清琪,陈刚,等.流感病毒两种快速抗原检测方法的对比分析[J].中国感染与化疗杂志,2017,17(1):29-32.[12]修敏,任妍妍.实时荧光定量PCR与细胞培养法在流感病毒检测中的比较[J].传染病信息,2019,32(4):336-337,340.[13]于娟,李红,饶华祥,等.流感高发季节150例流感病毒核酸阴性的流感样病例鼻咽分泌物呼吸道病毒检测分析[J].山东医药,2018,58(31):40-43.[14]刘江艺,刘艺端,李锋平,等.2006-2017年福建泉州市流感病原特征及检出率影响因素[J].公共卫生与预防医学,2018,29(4):32-35.[15]武涧松,原杰,贺婷婷,等.流感暴发期间5447例成人流感样病例的流感病毒检测结果与分布特征[J].中华医院感染学杂志,2018,28(23):3521-3526.[16]蒋小仙,李均,罗琴,等.2326例流感样病例流感病毒检测结果分析[J].浙江预防医学,2016,28(1):63-64.[17]刘静,李艳.2017年天津地区流感样病例病原学检测结果分析[J].中国卫生检验杂志,2019,29(10):1264-1266.[18]修璟威,李望晨,崔庆霞,等.2010~2018年山东省流感发病的季节性特征[J].山东大学学报(医学版),2020,58(1):112-117.[19]王越,郎兴莹,孙楠,等.大连市2014年-2017年监测年度流感病毒核酸检测结果分析[J].中国卫生检验杂志,2018,28(11):1397-1400.[20]Cunningham MJ,李伟,资海荣,等.2009-2013年南京市流感流行病学特征分析[J].中华疾病控制杂志,2017,21(1):3-7.[21]门玉梅,董鹏,李文秀,等.陕西省旬邑地区儿童呼吸道感染病毒病原学分析[J].山西医药杂志,2021,50(7):1061-1064.[22]刘天,翁熹君,张丽杰,等.湖北省荆州市流感监测哨点监测质量及流感病毒核酸检测阳性率影响因素分析[J].疾病监测,2019,34(10):891-894.[23]王小丽,李锋,韩同武,等.2009-2018年郑州市流感样病例病原学监测结果分析[J].河南预防医学杂志,2020,31(4):296-298,301.[24]史大伟,张艳茹,董艳,等.多重PCR检测方法在儿童流感样病例病原检测中的临床价值（附94例报告）[J].中国实用儿科杂志,2020,35(11):881-884.[25]孙颖,陈丹,黄珮珺,等.尿液标本保存时间对巨细胞病毒DNA检测的影响[J].实用心脑肺血管病杂志,2016,24:270.[26]宋倩,谢勇,严威敏,等.流感病毒咽拭子处理方式对其病毒分离率影响的研究[J].现代预防医学,2018,45(21):3945-3948.[27]张蓉,史海霞.标本因素对荧光定量荧光定量PCR检测HBV-DNA的影响[J].国际检验医学杂志,2017,38(19):2775-2777.[28]王晶,白江涛,张政,等.手足口病病例标本阳性检出率的影响因素分析[J].国际病毒学杂志,2018,25(2):122-126.

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更新日期/Last Update: 1900-01-01