[1]李 晶,周仁华,侍永伟,等.脑卒中后抑郁临床危险因素分析[J].医学信息,2022,35(17):107-109,113.[doi:10.3969/j.issn.1006-1959.2022.17.028]
　LI Jing,ZHOU Ren-hua,SHI Yong-wei,et al.Analysis of Clinical Risk Factors of Post-stroke Depression[J].Journal of Medical Information,2022,35(17):107-109,113.[doi:10.3969/j.issn.1006-1959.2022.17.028]
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脑卒中后抑郁临床危险因素分析()
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医学信息[ISSN:1006-1959/CN:61-1278/R]

卷:
35卷
期数:
2022年17期
页码:
107-109,113
栏目:
临床研究
出版日期:
2022-09-01

文章信息/Info

Title:
Analysis of Clinical Risk Factors of Post-stroke Depression
文章编号:
1006-1959（2022）17-0107-04
作者:
李 晶; 周仁华; 侍永伟; 等
（泰州市第四人民医院神经内科，江苏 泰州 225300）
Author(s):
LI Jing; ZHOU Ren-hua; SHI Yong-wei; et al.
(Department of Neurology,Taizhou Fourth People’s Hospital,Taizhou 225300,Jiangsu,China)
关键词:
脑卒中后抑郁; NIHSS评分; 低密度脂蛋白胆固醇; 胆红素
Keywords:
Post-stroke depression; NIHSS score; Low density lipoprotein cholesterol; Bilirubin
分类号:
R743.3
DOI:
10.3969/j.issn.1006-1959.2022.17.028
文献标志码:
A
摘要:
目的 分析急性缺血性脑卒中后抑郁（post-stroke depression，PSD）的临床危险因素。方法 选取2020年1月-4月我院明确诊断为急性缺血性脑梗死的101例患者作为研究对象，采用美国精神障碍诊断与统计手册第4版（DSM-IV）诊断标准将患者分为PSD组（n=33）和非PSD组（n=68）。采用单因素及多因素Logistic回归分析PSD的危险因素，并采用Pearson相关性分析胆红素水平与NIHSS评分的关系。结果 101例非重症急性缺血性脑卒中患者33例发生PSD（32.67%），其中轻度抑郁27例、中度抑郁4例，重度抑郁2例；PSD组与非PSD组年龄、BMI、高血压、糖尿病、冠心病、房颤、既往卒中史、吸烟饮酒史比较，差异无统计学意义（P＞0.05）；两组性别、出入院NIHSS、血清胆红素水平以及总胆固醇、LDL水平比较，差异有统计学意义（P＜0.05）；多因素Logistic回归分析显示，NIHSS评分和低密度脂蛋白胆固醇均为PSD的独立预测因素（P＜0.05）；Pearson相关性分析显示，胆红素水平与NIHSS评分呈正相关（r=0.400，P＜0.05）。结论 性别、神经功能缺损程度、低密度脂蛋白胆固醇、胆红素与急性缺血性脑卒中患者PSD发生密切相关，且神经功能缺损程度和低密度脂蛋白胆固醇是PSD发生的独立预测因子。针对以上高危人群进行合理筛查、定期随访、早期干预可能是减少PSD发生的有效方法。
Abstract:
Objective To analyze the clinical risk factors of post-stroke depression (PSD) after acute ischemic stroke.Methods A total of 101 patients with acute ischemic cerebral infarction diagnosed in our hospital from January to April 2020 were selected as the research objects. The patients were divided into PSD group(n=33) and non-PSD group(n=68) according to the diagnostic criteria of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). The risk factors of PSD were analyzed by univariate and multivariate Logistic regression, and the relationship between bilirubin level and NIHSS score was analyzed by Pearson correlation analysis.Results In 101 patients with non-severe acute ischemic stroke, PSD occurred in 33 cases (32.67%), including 27 cases of mild depression, 4 cases of moderate depression and 2 cases of severe depression. There was no significant difference in age, BMI, hypertension, diabetes, coronary heart disease, atrial fibrillation, previous stroke history, smoking and drinking history between PSD group and non-PSD group (P>0.05). There were significant differences in gender, admission and discharge NIHSS, serum bilirubin level, total cholesterol and LDL level between the two groups (P<0.05). Multivariate logistic regression analysis showed that NIHSS score and low density lipoprotein cholesterol were independent predictors of PSD (P<0.05). Pearson correlation analysis showed that bilirubin level was positively correlated with NIHSS score (r=0.400, P<0.05).Conclusion Gender, degree of neurological deficit, low density lipoprotein cholesterol and bilirubin are closely related to the occurrence of PSD in patients with acute ischemic stroke, and the degree of neurological deficit and low density lipoprotein cholesterol are independent predictors of PSD. Reasonable screening, regular follow-up and early intervention for the above high-risk groups may be effective methods to reduce the occurrence of PSD.

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更新日期/Last Update: 1900-01-01